Radical Approach Research Articles

Identification of common factors among fibrosarcoma, rhabdomyosarcoma, and osteosarcoma by network analysis

Sarcoma cancers are uncommon malignant tumors, and there are many subgroups, including fibrosarcoma (FS), which mainly affects middle-aged and older adults in deep soft tissues. Rhabdomyosarcoma (RMS), on the other hand, is the most common soft-tissue sarcoma in children and is located in the head and neck area. Osteosarcomas (OS) is the predominant form of primary bone cancer among young adults, primarily resulting from sporadically random mutations. This frequently results in the dissemination of cancer cells to the lungs, commonly known as metastasis. Mesodermal cells are the origin of sarcoma cancers. In this study, a rather radical approach has been applied. Instead of comparing homogenous cancer types, we focus on three main subtypes of sarcoma: fibrosarcoma, rhabdomyosarcoma, and osteosarcoma, and compare their gene expression with normal cell groups to identify the differentially expressed genes (DEGs). Next, by applying protein-protein interaction (PPI) network analysis, we determine the hub genes and crucial factors, such as transcription factors (TFs), affected by these types of cancer. Our findings indicate a modification in a range of pathways associated with cell cycle, extracellular matrix, and DNA repair in these three malignancies.Results showed that fibrosarcoma (FS), rhabdomyosarcoma (RMS), and osteosarcoma (OS) had 653, 1270, and 2823 differentially expressed genes (DEGs), respectively. Interestingly, there were 24 DEGs common to all three types. Network analysis showed that the fibrosarcoma network had two sub-networks identified in FS that contributed to the catabolic process of collagen via the G-protein coupled receptor signaling pathway. The rhabdomyosarcoma network included nine sub-networks associated with cell division, extracellular matrix organization, mRNA splicing via spliceosome, and others. The osteosarcoma network has 13 sub-networks, including mRNA splicing, sister chromatid cohesion, DNA repair, etc. In conclusion, the common DEGs identified in this study have been shown to play significant and multiple roles in various other cancers based on the literature review, indicating their significance.

Media Framing of Human Rights Violations: Unpacking Indian Radical Nationalist Policies

Abstract This systematic review examines the media framing of human rights violations, in the backdrop of radical nationalist movements in India. The study focuses on the Bharatiya Janata Party’s (BJP’s) governance and its association with a radical nationalist (Hindutva) ideology. The study aims to shed light on the International Media’s criticism of the party’s role in perpetuating anti-minority sentiments and provoking violence against them. Using an integrative review approach, this paper meticulously analyzed 34 selected articles, from research journals and newspapers, published between 2010 and 2022. Thematic analysis was used to identify recurring patterns and key themes related to the BJP’s radical nationalist approach and its impact on minorities. Findings from the existing literature and international media’s reporting reveal the BJP’s transformation from a political organization to a stubborn force, promoting radical nationalist principles to consolidate its power base. Furthermore, analysis shows that the enactment of the discriminatory Citizenship Amendment Act (CAA) triggered widespread protests whereas amending Articles 370 and 35A stripped Jammu and Kashmir of its autonomy, which resulted in human rights violations. In conclusion, the media content analysis highlights the human rights concerns due to the BJP’s radical nationalist approach and underscores an urgent need to make such policies that promote co-existence, inclusivity, and social cohesion to foster a pluralistic society.

Who is the Digital Sovereign?

Abstract The article theorizes the sovereign in recent digital democratic experiments. It demonstrates how the prevailing perspective is based on a liberal-technocratic understanding that overlooks important questions of organized collective power and identity. To address these limitations, the article contrasts the liberal-technocratic framework with a radical democratic approach. This alternative allows for reimagining the digital sovereign in two ways. First, it shifts the focus from the sovereign as a mere aggregation of networked individuals with fixed identities to one that opens up opportunities for ongoing identity construction and transformation. Second, a radical democratic approach emphasizes that the digital sovereign emerges from the individual and collective capacity to organize power.

Stanje in notranja razmerja v slovenskem naprednem (liberalnem) taboru na pragu 2. svetovne vojne

The article provides an outline of the development of the internal relations and divisions in the Slovenian progressive (liberal) camp in the years just before the Second World War and upon its start. After falling from power in 1935, the progressive camp was weak and internally fragmented. At the same time, the range of groups and ideological orientations found under the “progressive” umbrella was extremely wide as it extended far to the left and right sides of the political spectrum. The youth, in particular, were distinctly ideologically differentiated and radicalised. Some of them were highly susceptible to radical political approaches and moved towards fascism and communism. Especially when viewing the wider ideological camp, it is thus partly justified to posit a process of disintegration. At the same time, at least the core part maintained a consciousness of belonging to a common political camp, which was reflected by renewed connections between parties and groups on the eve of the war.

The Impact of Sensationalism on Urdu Press: A Quantitative Analysis

Urdu language newspapers were instrumental during the independence movement. Radical and ethical journalistic approach proved very effective and played a pivotal role in the creation of Pakistan. However, Urdu journalism changed over time and underwent structural as well as ideological transformation mostly dominated by corporate ownership in Pakistan. There have been commercial agents that use journalism for their corporate purposes. Despite huge concerns and open criticism, their presence has had a significant impact on newspaper practices today in a number of ways. The way news is reported, language choices and photographic selection, has been influenced by corporate as well as cross media ownership. Urdu press enjoys maximum readership in Pakistan and has subsequent influence on public perception and opinion making. Therefore, present study focuses on the impact of sensationalism on Urdu press. A quantitative approach has been adopted by using purposive sampling method. 100 respondents were sent with a carefully constructed questionnaire. Findings of the study show that Urdu press is sensational and dramatized in nature. Keywords: Urdu Journalism, Sensational, Dramatization, Public perception

A new therapeutic approach to Tauopathies: targeting presynaptic tau with antisense oligonucleotides to Synaptogyrin‐3

AbstractBackgroundThe protein Tau is central to several neurodegenerative disorders (“tauopathies”). “Tau‐tangles” (aggregations of the Tau protein) are a key hallmark of Alzheimer’s and many other diseases and Tau‐protein is mutated in several forms of dementia. In all these conditions, Tau causes complex, multifactorial defects in neurons that lead to cognitive decline. Under normal conditions, Tau is attached to axonal microtubules, but under pathogenic conditions it detaches and spreads throughout the neuron, including synapses. Work from my lab indicated that when Tau is present at pre‐synaptic terminals it binds to and clusters synaptic vesicles and identified Synaptogyrin‐3 as a physical interactor of Tau. My lab demonstrated that the partial loss of Synaptogyrin‐3 (Syngr3) restores working memory and rescues synaptic degeneration in mice that express pathogenic P301S Tau (“PS19”), a well‐accepted model for tauopathy that recapitulates features seen in patients, including synaptic loss, neuroinflammation and cognitive decline. Partial (and complete) loss of Syngr3 is benign in mice and fruit flies. Based on this, we pursued a radical alternative and innovative approach, supported by strong pre‐clinical data, to tackle Tau‐induced cognitive decline.MethodWe designed and synthetized oligonucleotides covering the whole Syngr3 transcript, and tested their activity in Neuro2A cells and primary cortical murine neurons in transfection and unassisted uptake conditions.ResultThrough this screen we found several active molecules, that were able to significantly downregulate Syngr3 transcript and protein levels. To find the best candidates, we performed dose‐response curves and time course evaluations in primary murine neurons, and we found several molecules that targeted different regions of the Syngr3 transcript with good activity, potency, and no evident toxic effects.ConclusionWe found several molecules that induce an effective and sustained reduction of Syngr3 expression. As part of the pre‐clinical evaluation, these molecules will be tested in vivo in PK/PD and acute toxicity studies in WT mice, to determine the best administration dosage and therapeutic window. Finally, we will evaluate the effect of our best candidates in a therapeutic setting, treating PS19 tau mice to assess if the acute removal of the protein can alleviate presynaptic tau toxicity and revert tau induced synaptic and cognitive defects.

Geography in the world part 2: Editorial

AbstractThis editorial introduces the second collection of ‘Geography in the World’. It highlights three key concerns raised by the contributors: the tension between conservative and radical approaches; collaborating across the global North–South divide; and diversity in Geography teaching programmes. Building on Part 1, the collection offers a resource for exploring some of the key challenges and opportunities geographers face globally.

5-Fluoro-1-Methyl-Pyrazol-4-yl-Substituted Nitronyl Nitroxide Radical and Its 3d Metal Complexes: Synthesis, Structure, and Magnetic Properties

The metal–radical approach is a well-established synthetic way toward multi-spin systems that relies on the coordination of stable radical ligands with transition metal ions. The advantage offered by the use of paramagnetic ligands is that metal–radical magnetic exchange coupling is direct between the magnetic orbitals of the radical and metal ion. With the aim of further exploring this approach, crystals of four heterspin complexes, [M(hfac)2LF]2 {M = Mn, Co, or Ni and hfac = hexafluoroacetylacetonate} and [Cu(hfac)2LF]n, were obtained using a new fluorinated pyrazolyl-substituted nitronyl nitroxide radical, 4,4,5,5-tetramethyl-2-(5-fluoro-1-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (LF) as a ligand. The newly synthesized complexes were fully characterized, including X-ray crystallography and magnetometry. XRD analysis revealed that complexes [M(hfac)2LF]2 have similar dimer structures in which a metal ion is in a six-coordinated environment with four O atoms from the two hfac ligands, one radical O atom, and one pyrazole N atom from ligand LF. Nonetheless, the packing patterns of the complexes were found to be considerably different. In [Mn(hfac)2LF]2, there are no magnetically important short contacts between manganese dimers. By contrast, in [Co(hfac)2LF]2 and [Ni(hfac)2LF]2, there are short contacts between non-coordinate O atoms of nitronyl nitroxide moieties. Magnetic behaviors of [M(hfac)2LF]2 showed that the M ions and the directly coordinated radicals are strongly antiferromagnetically coupled (JMn-ON = −84.1 ± 1.5 cm−1, JCo-ON = −134.3 ± 2.6 cm−1, and JNi-ON = −276.2 ± 2.1 cm−1; H^=−2JS⃑^MS⃑^NO). Notably, the magnetization of [Mn(hfac)2LF]2 having molecular structure proved to be accompanied by hysteresis. The [Cu(hfac)2LF]n complex has a chain-polymer structure with alternating magnetic fragments: three spin exchange clusters {ONO–Cu(II)–ONO} and {Cu(II)} ions. Despite the direct coordination of radicals, its magnetic properties are weakly ferromagnetic (JCu-ON = 14.8 ± 0.3 cm−1).

Clinical characteristics and treatment outcomes of angiosarcoma of the head and neck: A 17-year single-centre experience

Angiosarcomas in the head and neck region are aggressive tumours associated with high local recurrence and metastatic rates. We present our 17-year experience at the North of England Bone and Soft Tissue Tumour Service. A retrospective review of our prospectively maintained database was undertaken, looking for patients diagnosed with angiosarcomas affecting the head and neck. Data were gathered using a pre-defined proforma to include demographics, histological characteristics, treatment modalities, adjuvant therapies, local recurrence, distant spread, and disease-specific survival. A total of 23 patients (17 males, 6 females) were identified, with a mean age of 76 years at presentation. Fourteen presented with scalp lesions, whereas the remainder arose on the face. Eighteen patients underwent resection with curative intent, whereas three received palliative radiotherapy and two received comfort-based care only. Of the patients undergoing surgery, 12 had local flap reconstruction and 6 underwent free tissue transfer. Clear resection margins were obtained in nine cases (50%). Fourteen patients (78%) presented with local recurrence after surgery, and 11 (61%) developed distant metastases. The median disease-specific survival time for patients treated with curative intent was 38 months. Eight patients had mapping biopsies ahead of their resection; however, complete resection was achieved in only two cases. Angiosarcomas of the head and neck are associated with a poor prognosis, with most patients rapidly developing local recurrence, resulting in adverse clinical outcomes. Mapping biopsies do not demonstrate a clear advantage for achieving complete surgical resection. A radical surgical approach is warranted, given the aggressiveness of the pathology. However, there remains no consensus on optimal surgical management; we recommend further synthesising studies to determine the most appropriate treatment pathway.

Revelation after three decades of ablation therapy: two loops instead of a single re-entry loop drive atrial tachycardia

Revelation after three decades of ablation therapy: two loops instead of a single re-entry loop drive atrial tachycardia There is an urgent need to better understand and localise the sources of cardiac arrhythmia in order to improve its treatment. SmartHeart proposes a radical new approach—applying network theory to study cardiac arrhythmia mechanisms. Network theory has myriad applications throughout biology, physics and social sciences. However, it has never been applied to the heart. In this proposal, we will apply network theory to clinical data of cardiac arrhythmia, backed up by computer simulations, to automatically detect the source of the arrhythmia for complex atrial tachycardia, atrial fibrillation and ventricular tachycardia. As we will identify possible ablation targets, the goal of this project is to improve the treatment for the patient.

Modern Humanities and the Ancient Book: Karl Kerényi’s Media Theory

Abstract Karl Kerényi is now mostly remembered for his monographs on Greek mythological figures in the Bollingen Series and for his collaboration with Carl Gustav Jung from the 1940s on. The radical approach to mythology reflected in this work was Kerényi’s solution to what he perceived as a crisis of the humanities: a disciplinary fragmentation combined with the growing influence of the social sciences in the study of culture. Before he would have turned to the study of myth, Kerényi proposed media history as the foundation for the renewal of classical studies and the humanities in general. In a series of essays written in the 1930s, Kerényi theorized the media of ancient texts as central to cultural hermeneutics. His understanding of textual media as expressive of the essential characteristics of a culture was underpinned by a conservative-humanist critique of modernity. It shows strong affinities with the work of such figures as the cultural theorist Oswald Spengler. Offered as an alternative to what Kerényi considered the scientistic preoccupations rampant in modern academe, this vision is also clearly at odds with most later media-historical research and its interest in the affordances and social ramifications of the materiality of communication technologies.

Understanding the relationship between institutional pressures, supply chain integration and the adoption of circular economy practices

This paper explores the role of institutional pressures and supply chain integration in the adoption of Circular Economy practices. Using a Delphi-like approach and leveraging on a panel of 30 experts in the field of Circular Economy, this study aims to gain additional insights into how coercive, normative, and mimetic pressures can drive the implementation of circular supply chains. The findings reveal a hierarchy of institutional pressures, with coercive market and regulatory pressures having a greater impact compared to normative and mimetic pressures. Additionally, the study identifies various responses to these pressures, illustrating different trajectories towards the implementation of Circular Economy practices. Furthermore, the research investigates the role of supply chain integration. Generally, a higher level of supply chain integration can amplify the effect of institutional pressures, promoting the adoption of incremental Circular Economy practices. However, it is noteworthy to mention that supply chain integration may also hinder the adoption of more radical Circular Economy approaches, favouring the retention of linear supply chains.

How to Build Healthy Societies: A Thematic Analysis of Relevant Conceptual Frameworks.

As the Sustainable Development Goals deadline of 2030 draws near, greater attention is being given to health beyond the health sector, in other words, to the creation of healthy societies. However, action and reform in this area has not kept pace, in part due to a focus on narrower interventions and the lack of upstream action on health inequity. With an aim to guide action and political engagement for reform, we conducted a thematic analysis of concepts seeking to arrive at healthy societies. This paper drew on a qualitative thematic analysis of a purposive sample of 68 documents including political declarations, reports, peer reviewed literature and guidance published since 1974. Three independent reviewers extracted data to identify, discuss and critique public policy levers and 'enablers' of healthy societies, the "how." The first lever concerned regulatory and fiscal measures. The second was intersectoral action. The final lever a shift in the global consensus around what signifies societal transformation and outcomes. The three enablers covered political leadership and accountability, popular mobilization and the generation and use of knowledge. Documents focused largely on technical rather than political solutions. Even as the importance of political leadership was recognized, analysis of power was limited. Rights-based approaches were generally neglected as was assessing what worked or did not work to pull the levers or invest in the enablers. Frameworks typically failed to acknowledge or challenge prevailing ideologies, and did not seek to identify ways to hold or governments or corporations accountable for failures. Finally, ideas and approaches seem to recur again over the decades, without adding further nuance or analysis. This suggests a need for more upstream, critical and radical approaches to achieve healthy societies.

Electrochemical radical-polar crossover: a radical approach to polar chemistry

Electrochemical radical-polar crossover: a radical approach to polar chemistry

Woman, Life, Freedom, and the Question of Multiculturalism in Iranian Studies

The vast uprisings across Iranian cities in the fall of 2022 caught many of Iranian studies scholars and academic feminists in the diaspora off guard. My first confrontation was with trauma. Like many others, I worried about the lives and safety of my loved ones, political dissidents and prisoners from different ethnic backgrounds, feminists and queer activists on the ground, and, of course, the millennials and Gen Z, who unexpectedly emerged as the new revolutionaries. However, with the first wave of emotional encounters settled, the uprising unlocked another level of cognitive puzzlement critical to my academic life. I struggled to find comprehensive theoretical frameworks and supporting scholarship within Iranian studies or Iranian academic feminism to help my media and scholarly audiences grasp what was unfolding. In this reflective piece, I discuss how the scholarship of Iranian studies and feminism/s formulated the question of gender in liberal and radical essentialist multiculturalism and argue that Woman, Life, Freedom (Zan, Zendegi, Azadi; WLF) urges us to adopt an antiracist and radical democratic approach, deconstructing the imagined Iran in the scholarship, and reconstructing it as a welcoming and inclusive discursive space for racialized and queer Iranians.

New Models of Higher Education for Low-Income countries

In low-income countries, increasing access to higher education is particularly challenging. While tertiary education may boost a country's prosperity, the high cost of education, despite subsidies, remains a barrier to access. The digitisation of existing approaches to tertiary education is insufficient, and a more radical approach is needed.
 
 The Atlantic Technological University has been working on two approaches that hold potential for addressing this challenge. A work-based degree in engineering has placed a student in Mozambique in a mining company, where they will learn the required practical engineering skills and study online. Although this approach will allow the student to earn an income as they study, the fees will still be significant as it is based on existing forms of online learning. Separately, the university is developing a 2-year low-cost Engineering programme based on free online content, modest payment for examinations, and supervision of a capstone project.
 
 This paper focuses on the design of these programmes and the challenges involved. Attendees will learn how these new models of higher education for low-income countries could potentially address the cost barrier to access and significantly increase participation in tertiary education, leading to improved prosperity and economic growth.

Sexual Consent and Epistemic Partiality in Rape Fact-Finding

Feminist legal theory has contested rape laws and notions of sexual consent to better reflect the experiences of survivors and address power distortions in legal frameworks that perpetuate women’s subordination. In this paper, I explore an alternative form of criticism to consent-based rape laws and biases within legal systems. I argue that the justifications that are used to select and weigh evidence in rape cases are epistemically suspect because of the unreliability of their epistemic sources. My argument, building on radical realist social analysis in political theory, aims to unveil an epistemic defect in rape evidentiary procedures, which I call epistemic partiality. I suggest that this epistemic defect brings salient reasons to challenge rape laws based on ideals of consent. I hope to show that a radical realist approach may bring reasons to challenge rape laws and flaws in evidentiary systems without the need to centrally agree with or rely on feminist commitments and political goals. This type of criticism may effectively bypass certain limitations of feminist theory and potentially add to discussions focused on power distortions within legal systems.

Quality of life after rhinologic surgery (radical versus endoscopic approach)

Quality of life after rhinologic surgery (radical versus endoscopic approach)

Is aggressive tax planning a failure of tax adviser integrity?

PurposeThis paper aims to address the fundamentals of tax planning and seeks to focus on the opportunities and root causes for tax planning.Design/methodology/approachThe paper reviews the current state of tax planning with case studies that reveal fundamental statutory structural opportunities.FindingsWhile some, possibly many, tax advisers lack integrity and recommend tax structures to their clients that are inconsistent with reasonable interpretations of the tax law, most advisers, even very aggressive and creative advisers, probably do not. The paper suggests that it may be futile to seek to deter tax professionals from designing and marketing tax plans unless legislation makes tax advisers jointly responsible with their clients for their clients’ tax underpayments.Practical implicationsShort of such a radical approach, governments must commit first to altering the basic structure of their tax laws to make aggressive tax planning uninviting.Originality/valueThe paper offers original insights into the inseparability of the legislative process from the creation of unnecessary tax planning opportunities.

Radical Surgical Approach to Chronic Suppurative Osteomyelitis: Case Report

Diabetes mellitus is a systemic condition potentially related to an increased risk of progression of various infections such as chronic osteomyelitis by accelerating the inflammatory process with bone tissue necrosis and suppuration. Therefore, if there is no proper management of these infections, they can be life-threatening as they spread to deeper spaces in the head and neck. We describe the case of a 52-year-old male patient with a history of diabetes mellitus and grade III osteoarthritis who was diagnosed with chronic suppurative osteomyelitis of the mandible. He underwent a multidisciplinary surgical intervention in which he underwent a hemimandibulectomy with immediate mandibular reconstruction. The present case highlights the importance of early and radical treatment of patients with chronic suppurative osteomyelitis of the mandible and systemic comorbidities. In addition, this case presents a review of diabetes mellitus and the risk of developing odontogenic infections and complications when invading deeper spaces in the head and neck. Therefore, in this population, careful planning is required for early surgical and pharmacological treatment.