Purpose: Laparoscopic left pancreatectomy for pancreatic cancer has recently increased worldwide. With the attempt to improve its oncological safety by enlarging the resection margins, the radical antegrade modular pancreato-splenectomy (RAMPS) have been introduced. However, this procedure is technically challenging and it still needs to be standardized. We herein describe a standardized, step-by-step approach of the laparoscopic RAMPS at our center highlighting some technical tips and tricks. Methods: This procedure was performed on a 59-year-old man with a past history of diabetes and hypertension with non-specific abdominal pain. In the CT scan a 3 cm sized low attenuated mass in the body of the pancreas was detected with suspicious invasion of the posterior capsule. Results: After creation of a pneumoperitoneum via a 12 mm infra-umbilical port, three additional trocars are inserted. As showed in the video, surgery is started with division of the greater omentum. The inferior pancreatic border is dissected until the superior mesenteric vein and the origin of the splenic vein are exposed. Thereafter, the splenic artery and vein are dissected and divided. A window is opened between the pancreas and splenic vessels, and the neck of the pancreas is transected. The left side of the superior mesenteric artery is exposed until the left renal vein is identified. The retroperitoneal dissection continues along the anterior surface of the renal vein and kidney. Conclusions: Laparoscopic RAMPS procedure is a safe and feasible technique in experienced centers with advanced minimally invasive skills; it is recommended to standardize the technique for teaching purposes, replicability and to ensure patient safety