Types Of Radiation Research Articles

Mechanistic modelling of relative biological effectiveness of carbon ion beams and comparison with experiments

Objective. Relative biological effectiveness (RBE) plays a vital role in carbon ion radiotherapy, which is a promising treatment method for reducing toxic effects on normal tissues and improving treatment efficacy. It is important to have an effective and precise way of obtaining RBE values to support clinical decisions. A method of calculating RBE from a mechanistic perspective is reported. Approach. Ratio of dose to obtain the same number of double strand breaks (DSBs) between different radiation types was used to evaluate RBE. Package gMicroMC was used to simulate DSB yields. The DSB inductions were then analyzed to calculate RBE. The RBE values were compared with experimental results. Main results. Furusawa's experiment yielded RBE values of 1.27, 2.22, 3.00 and 3.37 for carbon ion beam with dose-averaged LET of 30.3 keV μm−1, 54.5 keV μm−1, 88 keV μm−1 and 137 keV μm−1, respectively. RBE values computed from gMicroMC simulations were 1.75, 2.22, 2.87 and 2.97. When it came to a more sophisticated carbon ion beam with 6 cm spread-out Bragg peak, RBE values were 1.61, 1.63, 2.19 and 2.36 for proximal, middle, distal and distal end part, respectively. Values simulated by gMicroMC were 1.50, 1.87, 2.19 and 2.34. The simulated results were in reasonable agreement with the experimental data. Significance. As a mechanistic way for the evaluation of RBE for carbon ion radiotherapy by combining the macroscopic simulation of energy spectrum and microscopic simulation of DNA damages, this work provides a promising tool for RBE calculation supporting clinical applications such as treatment planning.

The influence mechanism of supporting cities' development on the spatial expansion of economic development zones: Evidence from China's coast

A sustainable economy through the rational spatial expansion of coastal areas is an increasingly essential global topic. This paper aims to explore the mechanism by which supporting cities influence the spatial expansion of economic development zones (EDZs) in 264 coastal EDZs of China during 1995–2020. Meanwhile, the effects of variations in the distance between supporting cities and coastal EDZs and different city scales are considered. The results provide new explanations for realizing the sustainable development of the coastal economy by planning EDZs at a suitable location from the supporting city. The supporting cities’ economic strength can significantly contribute to the spatial expansion of coastal EDZs. The influence shows a distance decay law when the distance is less than 47.692 km, between 47.692 and 58.039 km, and greater than 58.039 km, with impact coefficients of 0.479, 0.393, and 0.212, respectively. The average spatial scale of coastal EDZs varies in an “inverted U–shape” with increasing distance. The average spatial scale of the urban general radiation type (47.692 km ≤ distance <58.039 km) is the largest. Supporting cities' scale affects the economic radiation range of supporting cities. The results suggest three implications for the future development of coastal EDZs. 1) Building the EDZ while incorporating practical development needs; 2) Scientifically planning the spatial layout of EDZs; 3) The synergistic development of supporting cities, transportation hubs, and EDZs.

Specialists Training for the Radiation Type of Non-Destructive Testing Based on Digital Technologies

The purpose of research is the development of application software, including VR-technologies, to increase the number of trained specialists in radiation type of nondestructive testing by reducing the per capita load on radiographic laboratories while maintaining the amount of practical training, acquired competencies and formed relevant professional skills.Methods. Prerequisites for virtualization of the process of training specialists in nondestructive testing of structural materials and fabricated products are defined. The main factors of demand for industrial radiography simulator in relation to the practical part of the educational cycle on radiation type of nondestructive testing are considered. As a result of the analysis the most significant aspects of practical training, available for their virtual realization, are singled out. The results of software implementation of mathematical models of physical and physicochemical processes of ionizing radiation, attenuation and absorption of penetrating radiation within the scope of digital twin of radiographic image generation as a result of simulation of the technological process of radiation type of nondestructive testing are presented.Results. Performed practical implementation of didactic materials in the form of hardware and software VR-simulator as part of digital educational environment to solve the problems of training, retraining, preparation for certification of personnel and providing admission of specialists to work on radiation type of nondestructive testing at facilities. Physical and technological aspects are analyzed, modeling, algorithmization and software implementation of VR-simulator are performed. A comprehensive approach to the creation of a learning environment with the use of digital technologies is presented. Considered are the main components, their goals and objectives. The structure of a practical lesson and illustrations of the training process in a virtual environment are given. The results of approbation of training programs with integration of classes in VR-simulator of industrial radiography have shown that the total time of practice of trainees increases by 40-55% with simultaneous reduction of per capita radiographic laboratory load by more than 25%. The main directions of development and scaling of software and hardware solution using VR-technologies are given.Conclusion. The developed and tested hardware-software solution together with the results of scientific research suggests the possibility of application and development directions of the digital educational system with VR-environment. The proposed approach application will allow to reduce environmental and biomedical risks by reducing the requirements to safety of training with the use of software and hardware solution. Automation of testing task generation and knowledge control procedures on the basis of software tools and mathematical models application, including methods of artificial intelligence, will allow to achieve training term reduction and will contribute to further increase in the number of trained specialists in various types and methods of nondestructive testing. With the functional capabilities expansion and evolutionary development of hardware-software solution (industrial radiography simulator) on the basis of unified modular approach, software libraries and hardware-software interfaces, virtual simulator simplifies organization of the process of specialists training and knowledge control. Practical value of the digital virtual environment (VR-environment) development is revealed due to the transfer and scaling of the obtained hardware-software solution to other types and methods of nondestructive testing according to GOST R 56542-2019 " Non-destructive testing. Classification of types and method".

Metabolomic Profiles in Tissues of Nonhuman Primates Exposed to Either Total- or Partial-Body Radiation.

A complex cascade of systemic and tissue-specific responses induced by exposure to ionizing radiation can lead to functional impairment over time in the surviving population. Current methods for management of survivors of unintentional radiation exposure episodes rely on monitoring individuals over time for the development of adverse clinical symptoms due to the lack of predictive biomarkers for tissue injury. In this study, we report on changes in metabolomic and lipidomic profiles in multiple tissues of nonhuman primates (NHPs) that received either 4.0 Gy or 5.8 Gy total-body irradiation (TBI) of 60Co gamma rays, and 4.0 or 5.8 Gy partial-body irradiation (PBI) from LINAC-derived photons and were treated with a promising radiation countermeasure, gamma-tocotrienol (GT3). These include small molecule alterations that correlate with radiation effects in the jejunum, lung, kidney, and spleen of animals that either survived or succumbed to radiation toxicities over a 30-day period. Radiation-induced metabolic changes in tissues were observed in animals exposed to both doses and types of radiation, but were partially alleviated in GT3-treated and irradiated animals, with lung and spleen being most responsive. The majority of the pathways protected by GT3 treatment in these tissues were related to glucose metabolism, inflammation, and aldarate metabolism, suggesting GT3 may exert radioprotective effects in part by sparing these pathways from radiation-induced dysregulation. Taken together, the results of our study demonstrate that the prophylactic administration of GT3 results in metabolic and lipidomic shifts that likely provide an overall advantage against radiation injury. This investigation is among the first to highlight the use of a molecular phenotyping approach in a highly translatable NHP model of partial- and total-body irradiation to determine the underlying physiological mechanisms involved in the radioprotective efficacy of GT3.

Spectral Characteristics of Polarization Radiation in the Water Window Range

The high-intensity and monochromatic radiation sources in the water window spectral range are desirable for many applications. One of the potential candidates of soft X-ray sources is polarization radiation produced by a charged particle passing through a thin foil. In the soft X-ray range near the absorption edges of a target material, the real part of dielectric permittivity can exceed unity, and the Tamm–Frank criterion is fulfilled. Thus, two types of radiation are produced: transition and Cherenkov radiation. In this report, we theoretically investigated the spectral characteristics of radiation produced in both cases when the Tamm–Frank criterion is met or not met. We showed the dependences of the spectrum as a function of thickness and the incidence angle. To describe the properties of polarization radiation and the complex dielectric permittivity, the polarization current approach and Henke’s model were used, respectively.

Effect of depth-absorbed dose distribution on the flexural modulus of carbon fiber–reinforced plastics in a radiation environment in radio-astronomical satellite orbit

Carbon fiber–reinforced polymers (CFRP) are used as structural materials for spacecraft due to their excellent physical properties. However, exposure in space to environmental factors, such as radiation, ultraviolet radiation, and thermal cycling, would alter these properties. Therefore, in order to ensure the safety and reliability of the spacecraft and the feasibility of the mission, it is necessary to evaluate the material’s space-environment resistance.The space environment consists of various types of energy and radiation, resulting in a non-uniform depth-absorbed dose distribution. This means that the absorbed dose is significantly higher at the surface of the material and lower with depth. However, reproducing this distribution in a ground-based test facility that typically uses a single energy irradiation is challenging. To overcome this challenge in ground-based testing, it is recommended that multiple radiation types and energies be irradiated to simulate the depth-absorbed dose distribution in a real space environment. However, there is a lack of understanding about the agreement between the depth-absorbed dose distribution obtained in real space environments and in ground-simulated tests. Additionally, the degree to which each depth region of the absorbed dose distribution affects material degradation is unknown. Hence, a faithful reproduction of the depth-absorbed dose distribution in a real space environment requires not only massive test facilities with significant financial investment but also a significant amount of time spent on irradiating those materials containing radiation that have practically no effect on material degradation.This study focused on analyzing the changes in the mechanical properties of CFRP due to radiation degradation using composite beam theory and mathematical models while considering the non-uniform depth-absorbed dose distribution in real space environments. The results of this study provide insight into which depth region of the depth-absorbed dose distribution is dominant for radiation-induced changes in mechanical properties when the CFRP plate thickness varies.

Spectral composition of secondary electrons based on the Kiefer-Straaten ion track structure model.

The major part of energy deposition of ionizing radiation is caused by secondary electrons, independent of the primary radiation type. However, their spatial concentration and their spectral properties strongly depend on the primary radiation type and finally determine the pattern of molecular damage e.g. to biological targets as the DNA, and thus the final effect of the radiation exposure. To describe the physical and to predict the biological consequences of charged ion irradiation, amorphous track structure approaches have proven to be pragmatic and helpful. There, the local dose deposition in the ion track is equated by considering the emission and slowing down of the secondary electrons from the primary particle track. In the present work we exploit the model of Kiefer and Straaten and derive the spectral composition of secondary electrons as function of the distance to the track center. The spectral composition indicates differences to spectra of low linear energy transfer (LET) photon radiation, which we confirm by a comparison with Monte Carlo studies. We demonstrate that the amorphous track structure approach provides a simple tool for evaluating the spectral electron properties within the track structure. Predictions of the LET of electrons across the track structure as well as the electronic dose build-up effect are derived. Implications for biological effects and corresponding predicting models based on amorphous track structure are discussed.

Semi-analytical solution for sound propagation from a moving directional source in a shallow-water waveguide

Understanding the waveguide fields produced by moving directional sources is of crucial importance in underwater acoustic detection. In practice, moving underwater targets often exhibit directionality, especially at high frequencies. Herein, we present a semi-analytical method to calculate the Doppler-shifted field (DSF) from a directional source moving horizontally in a range-independent, shallow-water waveguide. We develop a novel normal-mode model using a modal-projection approach with a perfectly matched layer. This comprehensively accounts for changes in modal shape, eigenvalue shifts, and the branch-integral contribution. We derive an analytical expression for the DSF based on Huygens’ principle, and the solution is presented as a sum over propagating eigenmodes, with the modal excitation determined by the source directivity depending upon the grazing angle of each pair of modal plane waves. This expression is valid for any type of radiator moving in a range-independent environment with a smoothly varying sound-speed profile. We then present a theoretical analysis of the Doppler beam shift produced by a piston-like radiator. This reveals that the observed angular offset of modal plane waves can be attributed to the Doppler beam shift and confirms that this is a new mechanism causing considerable differences between the fields generated by a directional moving source and by the same source at rest. This has potential value in various applications, particularly for underwater acoustic detection of moving targets.

Susceptibility to radiation adverse effects in veterans with Gulf War illness and healthy civilians

We evaluated whether veterans with Gulf War illness (VGWI) report greater ionizing radiation adverse effects (RadAEs) than controls; whether radiation-sensitivity is tied to reported chemical-sensitivity; and whether environmental exposures are apparent risk factors for reported RadAEs (rRadAEs). 81 participants (41 VGWI, 40 controls) rated exposure to, and rRadAEs from, four radiation types. The relations of RadAE-propensity (defined as the ratio of rRadAEs to summed radiation exposures) to Gulf War illness (GWI) presence and severity, and to reported chemical-sensitivity were assessed. Ordinal logistic regression evaluated exposure prediction of RadAE-propensity in the full sample, in VGWI, and stratified by age and chemical-sensitivity. RadAE-propensity was increased in VGWI (vs. controls) and related to GWI severity (p < 0.01) and chemical-sensitivity (p < 0.01). Past carbon monoxide (CO) exposure emerged as a strong, robust predictor of RadAE-propensity on univariable and multivariable analyses (p < 0.001 on multivariable assessment, without and with adjustment for VGWI case status), retaining significance in age-stratified and chemical-sensitivity-stratified replication analyses. Thus, RadAE-propensity, a newly-described GWI-feature, relates to chemical-sensitivity, and is predicted by CO exposure—both features reported for nonionizing radiation sensitivity, consistent with shared mitochondrial/oxidative toxicity across radiation frequencies. Greater RadAE vulnerability fits an emerging picture of heightened drug/chemical susceptibility in VGWI.

Effects of 700 and 3500 MHz 5G radiofrequency exposure on developing zebrafish embryos

Telecommunications industries are rapidly deploying the fifth generation (5G) spectrum and there is public concern about the safety and health impacts of this type of Radio Frequency Radiation (RFR), in part because of the lack of comparable scientific evidence. In this study we have used a validated commercially available setting producing a uniform field to expose zebrafish embryos (ZFe) to unmodulated 700 and 3500 MHz frequencies. We have combined a battery of toxicity, developmental and behavioral assays to further explore potential RFR effects. Our neurobehavioral profiles include a tail coiling assay, a light/dark activity assay, two thigmotaxis anxiety assays (auditory and visual stimuli), and a startle response - habituation assay in response to auditory stimuli. ZFe were exposed for 1 and 4 h during the blastula period of development and endpoints evaluated up to 120 hours post fertilization (hpf). Our results show no effects on mortality, hatching or body length. However, we have demonstrated specific organ morphological effects, and behavioral effects in activity, anxiety-like behavior, and habituation that lasted in larvae exposed during the early embryonic period. A decrease in acetylcholinesterase activity was also observed and could explain some of the observed behavioral alterations. Interestingly, effects were more pronounced in ZFe exposed to the 700 MHz frequency, and especially for the 4 h exposure period. In addition, we have demonstrated that our exposure setup is robust, flexible with regard to frequency and power testing, and highly comparable. Future work will include exposure of ZFe to 5G modulated signals for different time periods to better understand the potential health effects of novel 5G RFR.

Evaluation of shielding and interaction properties of different stainless steel alloys for nuclear power plant shielding

This study evaluated the gamma and neutron-shielding parameters, electron and charge particles’ interaction properties of three different stainless steel-based alloys (2507SS, 304SS and AISI1018) with densities of 7.82, 7.81 and 7.82, respectively for deployment in nuclear reactor construction. Gamma shielding parameters were evaluated with Phy-X/PSD, Py-MLBUF and GRASP computer programs within the energy range of 0.2 MeV to 15 MeV. The relative deviations (RD %) between two of these computational platforms were calculated. Fast Neutrons Effective Removal Cross-Sections (FNRCS) and Macroscopic Removal cross-section (MRCS) values for fast neutrons were calculated with Phy-X/PSD and MRCS software, while thermal/fast neutron attenuation factors were calculated with NGCals software. The continuous-slowing-down approximation (CSDA) range and total stopping power (TSP) values of H+ and He++ ions were estimated with SRIM Monte Carlo code in a wide energy range of 1–20 MeV. The projectile range of electrons was computed with ESTAR NIST software within the kinetic energy of 0.01–1000 MeV. Gamma-ray, thermal neutron and fast neutron transmission factors (TFs) values were calculated for all samples for a range of well-known energies. From the obtained results, all evaluated parameters were dependent on the composition of shielding materials, the type of radiation and the photon energy of the radiation. The maximum MAC values obtained from the three alloy samples are 0.1505 cm2/g for 2507SS, 0.1453 cm2/g for 304SS and 0.1459 cm2/g for AISI1018 at 0.02 MeV. These results projected 2507SS as a better shielding alloy when compared with other investigated alloy samples. Considering the closeness of densities of investigated alloy samples the shielding and interaction properties of all alloy samples gave excellent and similar results implying that all investigated alloys will effectively serve as a radiation-shielding material in a nuclear reactor.

Brachytherapy and 3D printing for skin cancer: A review paper.

Brachytherapy is a type of radiation therapy, in which a radiation source is placed directly or close to a tumor. It is commonly used to treat skin cancer, and enables precise irradiation treatment of affected area (planning target volume - PTV) while minimizing exposure dose to surrounding healthy tissue (organs at risk - OARs). Recently, the use of 3D printing has begun revolutionizing brachytherapy, as it allows manufacturing of custom-designed applicators for unique shape of skin topography, tumor, and surrounding tissues. Outcome of the combination of 3D printing and brachytherapy has several advantages over traditional treatment planning methods. Some of the advantages are intuitive, whereas others can be concluded from a literature overview as follows: 1) Possibility of developing patient-specific applicators that precisely match the shape of tumor area; 2) Reduction of the time required for applicator production, especially when custom-made devices are needed; 3) Reduction of manufacturing costs; 4) Treatment procedures improvement; 5) Improvement of safety measures accelerated by the development of smart materials (e.g., polymer filaments with admixture of heavy elements); 6) Possibility of nearly instant adjustment into tumor treatment (applicators can be changed as the tumor is changing its shape); and 7) Applicators designed to securely fit to treatment area to hold radioactive source always in the same place for each fraction. Consequently, tumor-provided dose is accurate and leads to effective treatment. In this review paper, we investigated the current state-of-the-art of the application of 3D printing in brachytherapy. A number of existing reports were chosen and reviewed in terms of printing technology, materials used, treatment effectiveness, and fabrication protocols. Furthermore, the development of future directions that should be considered by collaborative teams bridging different fields of science, such as medicine, physics, chemistry, and material science were summarized. With the indicated topics, we hope to stimulate the innovative progress of 3D printing technology in brachytherapy.

Essentials of Theranostics: A Guide for Physicians and Medical Physicists.

Radiopharmaceutical therapies (RPTs) are gaining increased interest with the recent emergence of novel safe and effective theranostic agents, improving outcomes for thousands of patients. The term theranostics refers to the use of diagnostic and therapeutic agents that share the same molecular target; a major step toward precision medicine, especially for oncologic applications. The authors dissect the fundamentals of theranostics in nuclear medicine. First, they explain the radioactive decay schemes and the characteristics of emitted electromagnetic radiation used for imaging, as well as particles used for therapeutic purposes, followed by the interaction of the different types of radiation with tissue. These concepts directly apply to clinical RPTs and play a major role in the efficacy and toxicity profile of different radiopharmaceutical agents. Personalized dosimetry is a powerful tool that can help estimate patient-specific absorbed doses, in tumors as well as normal organs. Dosimetry in RPT is an area of active investigation, as most of what we know about the relationship between delivered dose and tissue damage is extrapolated from external-beam radiation therapy; more research is needed to understand this relationship as it pertains to RPTs. Tumor heterogeneity is increasingly recognized as an important prognostic factor. Novel molecular imaging agents, often in combination with fluorine 18-fluorodeoxyglucose, are crucial for assessment of target expression in the tumor and potential hypermetabolic disease that may lack the molecular target expression. ©RSNA, 2023 Test Your Knowledge questions are available in the supplemental material.

Особенности применения установок Плазменный фокус в радиационном и космическом материаловедении

The features of the use of Plasma Focus (PF) devices in the field of radiation and space materials science related to the specific generation of several types of radiation in the working chambers of the PF are considered. It is noted that the main role in the damage and modification of the structural state of the surface layers of materials irradiated in the cathode zone of the PF working chamber is played by powerful pulsed beams of working gas ions and flows of high-temperature plasma in the nano- and microsecond range of pulse duration. It is shown that in addition to the common combined beam-plasma effect on a target sample, PF installations allow the possibility of separate irradiation of the target material with ion and plasma flows. Three methods for separating pulsed flows of hot plasma and fast ions in space and time in a PF installation, described in the literature, are presented. It is noted that PF installations are a promising tool for solving fundamental and applied problems in radiation and space materials science, including for simulation experiments focused on problems of thermonuclear energy and aerospace engineering. It is also indicated that hard X-ray pulses with a duration in the nanosecond range, arising from pulsed discharges in the PF chamber, can be used for diagnosing fast processes, in particular for non-destructive flaw detection of machines and mechanisms during their operation.

Enclosed thermal management method for high-power photovoltaic inverters based on heat pipe heat sink

Photovoltaic (PV) inverter plays a crucial role in PV power generation. For high-power PV inverter, its heat loss accounts for about 2% of the total power. If the large amount of heat generated during the operation of the inverter is not dissipated in time, excessive temperature rise will reduce the safety of the devices. This paper proposes a closed PV inverter structure based on heat pipe and liquid cooling which overcomes the noise, dust and other problems caused by traditional air-cooling heat dissipation method and reduces cost of the volume occupied inside the body. Heat is dissipated through heat pipes, which are efficient heat transfer units. A simulation model of the actual cabinet was established using computational fluid dynamics (CFD), and the maximum junction temperature in the inverter was investigated under different coolant temperatures, flow rates, cooling liquid and heat loads. The results showed that the liquid cooling heat dissipation structure can effectively dissipate the heat inside the cabinet. The impact of two different types of heat sink used for power modules on temperature uniformity was studied. The results indicated that the 9-heat pipe type heat sink has better heat dissipation and uniform hot spots performance, the maximum heat source temperatures in the chip and capacitor were reduced by 9.91?C and 7.49?C respectively. Finally, the performance of the two types of radiators under different heat loads was studied.

Radiolysis of bituminized radioactive waste: a comprehensive review

In the realm of radioactive waste management, the impact of radiolysis on bitumen and bituminized radioactive waste also called bituminized waste product (BWP) is considered one of the most significant factors influencing structural changes and the generation of radiolysis gas bubbles. This review provides a comprehensive overview of several studies that have explored the intricate interaction between radiation and various types of bitumen, to gain a better understanding of how such waste ages when exposed to radiation. While these studies provide insights into the diverse effects of radiolysis on bitumen, they also highlight numerous unanswered questions. The absence of gas bubbles does not necessarily indicate an absence of gas production, leaving further research to be undertaken. The complexities of bitumen radiolysis offer multiple avenues for future investigation, aiming to enhance our understanding and provide comprehensive solutions for bituminous radioactive waste management. Among the studied types of bitumen, blown R85/40 bitumen and straight-run distilled bitumen with a penetration grade of 70/100 stands out due to their widespread use in immobilizing co-precipitated radioactive sludges. These bituminous matrices play an essential role in understanding the broader implications of radiolysis within the context of bituminous waste management. This review underscores the significance of further research into radiolysis and bitumen ageing, emphasizing the need for a more in-depth exploration of these complex phenomena and their implications for the long-term safety and efficacy of repositories and disposal facilities.

Comparative study of dose for different fluence of neutron

The comparative study aims to investigate the dose received by materials exposed to different fluence of neutron radiation. The research is significant in the field of nuclear energy and radiation protection, as neutron radiation is one of the most common types of radiation produced by nuclear reactions. In this study, various materials are exposed to different fluence of neutron radiation, and the dose received by each material was measured using dosimeters. The results showed that the dose received by the materials increased with increasing fluence of neutron radiation. Furthermore, the study found that the dose-response relationship different between different materials, highlighting the importance of material selection in radiation protection. The study concludes that a better understanding of the dose-response relationship for different materials can help in the development of more effective radiation shielding materials and improve radiation safety in various applications.

Material Discrimination Using X-Ray and Neutron

Background: A nondestructive test is commonly used to inspect the surface defects and internal structure of an object without any physical damage. X-rays generated from an electron accelerator or a tube are one of the methods used for nondestructive testing. The high penetration of X-rays through materials with low atomic numbers makes it difficult to discriminate between these materials using X-ray imaging. The interaction characteristics of neutrons with materials can supplement the limitations of X-ray imaging in material discrimination.Materials and Methods: The radiation image acquisition process for air-cargo security inspection equipment using X-rays and neutrons was simulated using a GEometry ANd Tracking (Geant4) simulation toolkit. Radiation images of phantoms composed of 13 materials were obtained, and the R-value, representing the attenuation ratio of neutrons and gamma rays in a material, was calculated from these images.Results and Discussion: The R-values were calculated from the simulated X-ray and neutron images for each phantom and compared with those obtained in the experiments. The R-values obtained from the experiments were higher than those obtained from the simulations. The difference can be due to the following two causes. The first reason is that there are various facilities or equipment in the experimental environment that scatter neutrons, unlike the simulation. The other is the difference in the neutron signal processing. In the simulation, the neutron signal is the sum of the number of neutrons entering the detector. However, in the experiment, the neutron signal was obtained by superimposing the intensities of the neutron signals. Neutron detectors also detect gamma rays, and the neutron signal cannot be clearly distinguished in the process of separating the two types of radiation. Despite these differences, the two results showed similar trends and the viability of using simulation-based radiation images, particularly in the field of security screening. With further research, the simulation-based radiation images can replace ones from experiments and be used in the related fields.Conclusion: The Korea Atomic Energy Research Institute has developed air-cargo security inspection equipment using neutrons and X-rays. Using this equipment, radiation images and R-values for various materials were obtained. The equipment was reconstructed, and the R-values were obtained for 13 materials using the Geant4 simulation toolkit. The R-values calculated by experiment and simulation show similar trends. Therefore, we confirmed the feasibility of using the simulation-based radiation image.

Evaluation of the effect of the helium-neon laser (632.8 nm) on erythrocyte sedimentation rate (ESR) and packed cell volume (PCV)

Erythrocyte aggregation is considering an essential physiological phenomenon in blood circulation, the interaction of lasers with biomaterials like blood is a crucial topic of study. It is a fundamental property of healthy blood that is crucial to the cardiovascular system. Evaluation of the vital processes of blood microscopically and in laboratory by examining the packed cell volume and erythrocyte sedimentation rate upon exposure to laser radiation for three different times. The study included 15 healthy people. Microscopic examination, packed cell volume and erythrocyte sedimentation rate methods was used during the period of examination the red blood cells and exposure of them to laser radiation for two different periods of time, recording the results after all period of time and comparing them with the control group. In this study, the effect of radiation on packed cell volume and erythrocyte sedimentation rate was observed. In terms of viscosity speed and deposition for different periods of time, it was observed that when packed cell volume are exposed to radiation for a certain period of time (10 minutes), their values will decrease as a result of the amount of radiation generated against them, and this decrease increases when the time period increases (15 minutes) .While the erythrocyte sedimentation rate is is inversely proportional to PCV, there is an increase in the erythrocyte sedimentation rate when exposed to radiation. While the microscopic examination has shown that various deformability values have varying impacts on the degree of aggregation when the radiation duration increases over long periods, which therefore has an impact on deposition. The blood is affected when exposed to large amounts of radiation or any external conditions, which lead to the emergence of problems that may negatively affect the various functions of the blood. Therefore, knowing the type of radiation and concentration are very important to know these effects. Preferred from researchers to do more research on the effect of radiation on various blood functions

The role of the ImmunatuRNA® complex in promoting skin immunity and its regenerative abilities: Implications for antiaging skincare.

Recent advancements in cosmetic science have ushered in a new era of skincare strategies, with a focus on utilizing natural bioactive ingredients to enhance skin health and combat premature aging. The skin, as the largest organ of human body, provides as a vital protective barrier against external hazards such as environmental pollutions, toxins, and radiation. However, intrinsic and extrinsic factors, including various types of radiation, reduced air quality, and increased exposure to pollutants, lead to an imbalance in the skin's immune system, significantly reducing the skin's ability to regenerate and accelerating skin aging. Therefore, there is an emerging need to develop innovative skincare strategies that could support the skin's immune capacity by strengthening antioxidant protection, skin regeneration, and repair. Plant-derived compounds, along with naturally sourced ingredients, show promise in accelerating wound healing, especially when incorporated into cosmetic formulation. ImmunatuRNA® stands as a prime example of a biologically active complex, uniquely comprising yeast-derived RNA, marine exopolysaccharides, and natural hyaluronic acid, that exhibits high antioxidant activity and exerts beneficial modulatory effects on skin microbiota, thereby positively influencing skin immunity. The main aim of this study was to investigate the potential of the ImmunatuRNA® complex in promoting skin regeneration and reducing signs of skin aging, both through the use of invitro human skin cultures and the evaluation of clinical trials in healthy volunteers. The results of conducted experimental studies have shown that the ImmunatuRNA® complex demonstrated significant positive effects on the immunity and repair capabilities of the skin, characterized by increased fibroblast proliferation, enhanced glycosaminoglycan synthesis, and reduced oxidative stress. Furthermore, use of the complex also significantly accelerated wound healing following mechanically-induced damage in the keratinocytes, demonstrated as reduction in wound margins measurement, new cell production, and an increase in regeneration speed. In addition, conduced clinical study on healthy human volunteers with various skin types confirmed that use of cosmetic products that incorporate the ImmunatuRNA® complex within the formulation can visibly improve skin condition, appearance, and general health, achieved by increased skin hydration and elasticity, reduced wrinkles, and enhanced skin firmness. This study confirms the usefulness of the ImmunatuRNA® complex in the innovative antiaging cosmetic products that can be suitable for all skin types, including sensitive skin. The inclusion of naturally sourced bioactives, as those found in ImmunatuRNA® complex, represents a promising advancement in holistic natural skincare that consumers appreciate. The active ingredients of the complex support the skin's immunity, fostering its repair and protecting against oxidative damage, thus maintaining skin homeostasis and promoting its regenerative capacity. Further research is necessary to explore the long-term effects of ImmunatuRNA® complex on skin health and its potential applications in innovative skincare formulations.