Purpose:When quality assurance (QA) of patient treatment beam is performed, homogeneous water equivalent phantom which has different structure from patient's internal structure is normally used. In these days, it is possible to make structures which have same shapes of human organs with commercialization of 3D‐printer. As a Result, structures with same shape of human organs made by 3D‐printer could be used to test qualification of treatment beam with greater accuracy than homogeneous water phantom. In this study, we estimated the dose response of 3D‐printer materials to test the probability as a humanoid phantom or new generation of compensator tool.Methods:The rectangular products with variety densities (50%, 75% and 100%) were made to verify their characteristics. The products for experiment group and solid water phantom and air for control group with 125 cubic centimeters were put on solid water phantom with enough thickness. CT image of two products were acquired to know their HU values and to know about their radiologic characteristics. 6MV beams with 500MU were exposed for each experiment. Doses were measured behind the 3D‐printed products. These measured doses were compared to the results taken by TPS.Results:Absorbed dose penetrated from empty air is normalized to 100%. Doses measured from 6MV photon beams penetrated from 50%, 75% and 100% products were 99%, 96% and 84%, respectively. HU values of 50%, 75% and 100% products are about −910, −860 and −10.Conclusion:3D‐printer can produce structures which have similar characteristics with human organ. These results would be used to make similar phantoms with patient information.This work was supported by the Nuclear Safety Research Program (Grant No. 1305033 and 1403019) of the Korea Radiation Safety Foundation and the Nuclear Safety and Security Commission and Radiation Technology Development Program (2013M2A2A4027117) of the Republic of Korea.