In the United States, federal agencies are responsible for setting national policy and performance expectations for radiation protection programs. National policy establishes a regulatory regime, under which society can realize the beneficial uses of radiation while at the same time protecting workers, the public, and environment from the potential hazards of radiation. The challenges facing federal agencies continue to revolve around finding the right balance between benefit and adverse impact. Federal agencies are petitioned to support the research community to provide a sound scientific basis for informing the decision-making process related to radiation protection policy. The federal agencies are further challenged to consider the deliberations of the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) who bring together the best technical minds in the field to consider the latest scientific information and provide recommendations for establishing comprehensive and coherent radiation protection programs. The uncertainty inherent in research and the conservatism in the models and recommendations of the ICRP and NCRP should be transparent and communicated because determining the level of uncertainty and the degree of conservatism acceptable to society is a challenge for, and the responsibility of, the federal agencies in creating performance-based policies in public health and radiation protection. It is through the federal government's open, inclusive, and democratic processes where society strikes the balance that defines adequate radiation protection policy, builds public trust, and allows the radiation protection professionals to properly implement and manage that policy.