When we speak about standards we may well ask ourselves what we mean. To most people standards mean something firmly fixed, or at least reproducible—something quite permanent or something that is quite definitely definable. As a matter of fact, there are few absolute standards. We may think of physical standards, such as the meter-bar, that can be stored away in a vault and can confidently be expected to remain the same, year in and year out. Or we may have what we call standard preparations. These are used, in the main, for checking measurement methods or technics. Standard samples of steel, for example, after careful analysis in the laboratory are sent out to the mill, where they are run through an analysis procedure as a check on its accuracy. Again, we have standards of radioactivity—a radionuclide accurately measured in the laboratory and then used to check measurement technics in a hospital or some other laboratory. In the field of human applications we have what may be called biological standards. These are frequently based on some specified biological result produced in an animal exposed to a particular material. The proving of a drug against a biological standard involves the exposure of a number of animals and then a statistical analysis of the final result. By its very nature, this is a procedure that cannot use man as the standardizing animal. But at least we have a procedure which for most cases will determine the potency of a biological agent within some range of certainty. There is much talk today about radiation protection standards. Here the so-called standards are based mainly on long experience with man working in a known environment of radiation, followed by the exercise of technical judgment as to whether or not an effect may have been produced upon him. Radiation protection standards do not permit of direct testing. Indeed, most of them should not be called standards at all. They might much better be designated as radiation protection guides. Actually, most of our radiation protection criteria of today are based on absence of the demonstration of any deleterious influence. Because of our limited knowledge of the effect of low levels of radiation on animals, and the almost nonexistent knowledge of the effects of small doses of radiation on man, the permissible exposure levels for radiation workers have been set low enough so that there is a negligible probability of radiation damage occurring to the exposed individual.