Harmful Radiation Research Articles

An integrated approach to estimate storage reliability with masked data from series system

Storage reliability is of importance for the products that largely stay in storage in their total life-cycle such as warning systems for harmful radiation detection, etc. Usually, the field-testing data can be available, but the failure causes for a series system cannot be always known because of the masked information. In this paper, the storage reliability model with possibly initial failures is studied on the statistical analysis method when the masked data are considered. To optimize the use of the masked survival data from storage systems, a technique based on the least squares (LS) method with an EM-like algorithm, is proposed for the series system. The parametric estimation procedure based on the LS method is developed by applying the algorithm to update the testing data, and then the LS estimation for the initial reliability and failure rate of the components constituting the series system are investigated. The results should be useful for accurately evaluating the production reliability, identifying the production quality, and planning a storage environment.

Lightweight and flexible Ag-wrapped polyimide aerogel fabrics for electromagnetic interference shielding

Lightweight, flexible and highly effective electromagnetic interference (EMI) shielding fabrics are urgent demanded to protect the human body from harmful electromagnetic radiation. However, the design of fiber microstructures for achieving high-performance EMI shielding still remains significant challenges. Herein, novel EMI shielding fabrics have been designed based on polydopamine-assisted Ag deposition on polyimide (Ag@PI) aerogel fabrics. The Ag@PI aerogel fabric integrates highly conductive Ag and leverages the three-dimensional porous structure of aerogel to facilitate multiple reflections and interface polarization of electromagnetic waves. The Ag@PI aerogel fabrics exhibit ultra-high electromagnetic interference shielding performance of 89.4 dB owing to their unique porous structure, while the Ag@PI fabric without porous structure is only 65.1 dB. The normalized specific shielding effectiveness (SSE) of the Ag@PI aerogel fabrics is up to 812.7 dB cm3 g−1, significantly exceeding that of other EMI shielding textiles reported so far.

Evaluation of synthetically generated computed tomography for use in transcranial focused ultrasound procedures.

Transcranial focused ultrasound (tFUS) is a therapeutic ultrasound method that focuses sound through the skull to a small region noninvasively and often under magnetic resonance imaging (MRI) guidance. CT imaging is used to estimate the acoustic properties that vary between individual skulls to enable effective focusing during tFUS procedures, exposing patients to potentially harmful radiation. A method to estimate acoustic parameters in the skull without the need for CT is desirable. We synthesized CT images from routinely acquired T1-weighted MRI using a 3D patch-based conditional generative adversarial network and evaluated the performance of synthesized CT (sCT) images for treatment planning with tFUS. We compared the performance of sCT with real CT (rCT) images for tFUS planning using Kranion and simulations using the acoustic toolbox, k-Wave. Simulations were performed for 3 tFUS scenarios: (1)no aberration correction, (2)correction with phases calculated from Kranion, and (3)phase shifts calculated from time reversal. From Kranion, the skull density ratio, skull thickness, and number of active elements between rCT and sCT had Pearson's correlation coefficients of 0.94, 0.92, and 0.98, respectively. Among 20 targets, differences in simulated peak pressure between rCT and sCT were largest without phase correction () and smallest with Kranion phases (). The distance between peak focal locations between rCT and sCT was for all simulation cases. Real and synthetically generated skulls had comparable image similarity, skull measurements, and acoustic simulation metrics. Our work demonstrated similar results for 10 testing cases comparing MR-sCTs and rCTs for tFUS planning. Source code and a docker image with the trained model are available at https://github.com/han-liu/SynCT_TcMRgFUS.

Stratospheric dynamics modulates ozone layer response to molecular oxygen variations

Photolysis of molecular oxygen (O2) sustains the stratospheric ozone layer and is thereby protecting living organisms on Earth by absorbing harmful ultraviolet radiation. In the past, atmospheric O2 levels were not constant, and their variations are thought to be responsible for the extinction of some species due to the thinning of the ozone layer. Over the Phanerozoic Eon (last ∼500 Mio years), the O2 volume mixing ratio ranged between 10% and 35% depending on the level of photosynthetic activity of plants and oceans. Previous estimates, mostly performed by simplified 1-D models, showed different ozone (O3) responses to atmospheric O2 changes within this range, such as monotonically positive or negative correlations, or displaying a maximum in the O3 column around a certain O2 level. Here, we assess the ozone layer sensitivity to atmospheric O2 varying between 5% and 40% with a state-of-the-art 3-D chemistry-climate model (CCM). Our findings show that the O3 layer thickness maximizes around the current mixing ratio of O2, 21% ± 5%, while lower or higher levels of O2 result globally in a reduction of total column O3. At low latitudes, the total column O3 is less sensitive to O2 variations, because of the “self-healing” effect, namely, a vertical dipole in the tropical ozone response. Mid- and high-latitude O3 columns that are largely affected by transport of O3 from the tropics, however, are much more sensitive to O2 with changes up to 20 DU even for small (±5%) O2 perturbations. We show that these variations are largely driven by the radiative impact of O3 on stratospheric temperatures and on the strength of the Brewer-Dobson circulation (BDC), indicating chemistry-radiation-transport feedback. High O2 cases result in an acceleration of the BDC and vice versa, which always works in favor of the negative part of the O3 anomaly dipole in the tropics being more effectively transported to the mid- and high-latitudes than the positive one. Although there are other factors strongly influencing O3/O2 relationship on the Phanerozoic Eon timescales that have not been considered here, our results and the presented mechanism bring useful insights for other studies focusing on the long-term O3/O2 relationship.

Hot climates in urban South Asia: Negotiating the right to and the politics of shade at the everyday scale in Karachi

Although the climate has admittedly always been hot and humid in cities like Karachi, increasingly hotter temperatures are exacerbating the impact of heat on informal, precariously employed outdoor workers such as street vendors, guards and rickshaw drivers, who must negotiate their right and access to shade at the everyday scale. Recalling Mike Davis’ radical, political claim that shade is an inalienable human right, this paper proposes that few people working in the outdoor spaces of the South Asian city today understand or experience shade in these terms. Rather shade is something that must be claimed, alongside other rights and entitlements. Moreover, shade alone is insufficient as it cannot reduce the exposure of bodies to harmful ambient radiations and overall thermal discomfort. This paper makes three broad propositions for outlining a theory for the social study of shade in the South Asian city. By paying closer attention to the ways that outdoor workers negotiate shade in Karachi, this paper opens up for analysis a wider spectrum of claims-making activity in changing South Asian urban climates. It places workers’ search for shade in the broader context of shade policing and urban management aimed at creating spatial as well as social order. Finally, this article emphasises key directions and questions for future research.

Automatic generation of subject-specific finite element models of the spine from magnetic resonance images.

The generation of subject-specific finite element models of the spine is generally a time-consuming process based on computed tomography (CT) images, where scanning exposes subjects to harmful radiation. In this study, a method is presented for the automatic generation of spine finite element models using images from a single magnetic resonance (MR) sequence. The thoracic and lumbar spine of eight adult volunteers was imaged using a 3D multi-echo-gradient-echo sagittal MR sequence. A deep-learning method was used to generate synthetic CT images from the MR images. A pre-trained deep-learning network was used for the automatic segmentation of vertebrae from the synthetic CT images. Another deep-learning network was trained for the automatic segmentation of intervertebral discs from the MR images. The automatic segmentations were validated against manual segmentations for two subjects, one with scoliosis, and another with a spine implant. A template mesh of the spine was registered to the segmentations in three steps using a Bayesian coherent point drift algorithm. First, rigid registration was applied on the complete spine. Second, non-rigid registration was used for the individual discs and vertebrae. Third, the complete spine was non-rigidly registered to the individually registered discs and vertebrae. Comparison of the automatic and manual segmentations led to dice-scores of 0.93-0.96 for all vertebrae and discs. The lowest dice-score was in the disc at the height of the implant where artifacts led to under-segmentation. The mean distance between the morphed meshes and the segmentations was below 1mm. In conclusion, the presented method can be used to automatically generate accurate subject-specific spine models.

External Bremsstrahlung Studies on Films of Lead Monoxide Filled Polycarbonate Composite

The development of high-Z (high atomic number) radiation shielding materials is vital in order to protect personnel who work with harmful gamma radiation sources. At the same time, the emission of external bremsstrahlung (EB) radiation in those shielding materials when the radiation source emits beta particles as well as gamma radiation is also of prime concern.The production of EB in films of lead monoxide (PbO) loaded polycarbonate (PC) composite at eleven different filler levels (FLs) varying, in terms of weight fraction, from 0.0 % up to 10.0 % were investigated experimentally by using beta particles from strontium-90/yttrium-90 (90Sr/90Y) radioactive source. A nonlinear relation is observed between EB intensity and target thickness. The effective atomic numbers of the prepared PbO-filled PC composite films (at different FLs) were determined via EB measurements, followed by calculations, and the values obtained were compared with the modified atomic numbers which were determined for the same composite films (at different FLs) using the Markowicz and Van Grieken equation, and it was found that they are in good agreement. Finally, the atomic number dependence of EB in these composite films (PbO-filled PC composites) has been studied. It is obtained that the intensity of EB spectra depends on the square of the atomic number of the target material.

Bilgisayarlı Tomografi İle Yapılan Perkütan Torasik Kitle Biyopsilerinde Lenfositlerdeki DNA Hasarının Değerlendirilmesi

Purpose: The increase in the medical and industrial uses of radiation in the last century has caused people to be exposed to higher doses of radiation. Although the harms of high-dose radiation on human health are known, the effects of low-dose radiation on health have not yet been fully elucidated. In this study, we aimed to investigate DNA damage in lymphocytes in patients with lung, pleura/thoracic wall masses planned for percutaneous thoracic mass biopsy with computed tomography (CT). Methods: Sixteen patients referred to the Radiology Clinic of a public institution hospital with lung, pleura/thoracic wall masses and scheduled to undergo a CT-guided percutaneous biopsy were included in the study. All the biopsies were performed with a 128-slice CT device (Definition AS, Siemens Medical Solutions, Forchheim, Germany). Lymphocytes were analyzed using the comet assay in the venous blood samples taken from the patients before and after the biopsy procedure. DNA damage was quantitatively evaluated with the imaging analysis method. Results: In the CT analysis data of the study group, the mean scan distance was found to be 19.92±3.60 sec, the mean total milliampere-seconds was 807.43±304.51, and the mean dose-length product was 765.44±278.36 mGy.cm. The mean comet score was 200.50±40.54 for the cells that migrated before the procedure and 237.37±27.85 for those migrating after the procedure. The post-procedure comet scores significantly increased compared to the pre-procedure comet scores (p=0.038). Conclusion: Post-procedure DNA damage was detected in patients who underwent CT-guided percutaneous biopsy.

Fabrication of silver/polyaniline/aminated graphene oxide coated textiles for electromagnetic interference shielding application within the different bands of frequency

The interference and pollution caused by electromagnetic radiation have become serious concerns due to the advancements in telecommunications and electronic technology. Highly efficient electromagnetic interference (EMI) shielding materials are thus urgently needed. The primary purpose of this research is to design silver/polyaniline/aminated graphene oxide based EMI shielding textiles over a wide frequency range to protect humans from harmful electromagnetic radiation. For this, layer by layer strategy was adapted to develop conductive textiles for remarkable EMI shielding performance in a wide range of frequency. Electroless plating of silver was performed on polyaniline-based aminated graphene oxide (AGO) fabric to achieve a multilayered structure. Our shielding effectiveness (SE) findings demonstrate that these modified fabrics provide excellent EMI shielding efficiency across multiple frequency bands, including UHF, L-band, S-band, C-band, and X-band. The modified fabric showed EMI SE greater than 40 dB in all bands of frequency and it is greater than the commercial requirement. Moreover, these fabrics are antibacterial and hydrophobic in nature and the greatest antibacterial activity was exhibited by silver/polyaniline/aminated graphene oxide fabric about 97 % and 99% against E.coli and S. aureus respectively. These modified fabrics have the potential to significantly reduce electromagnetic radiation pollution and protect human life owing to their exceptional EMI shielding properties.

Exposure to ultraviolet-B radiation increases the susceptibility of mosquitoes to infection with dengue virus.

By 2100, greenhouse gases are predicted to reduce ozone and cloud cover over the tropics causing increased exposure of organisms to harmful ultraviolet-B radiation (UVBR). UVBR damages DNA and is an important modulator of immune function and disease susceptibility in humans and other vertebrates. The effect of UVBR on invertebrate immune function is largely unknown, but UVBR together with ultraviolet-A radiation impairs an insect immune response that utilizes melanin, a pigment that also protects against UVBR-induced DNA damage. If UVBR weakens insect immunity, then it may make insect disease vectors more susceptible to infection with pathogens of socioeconomic and public health importance. In the tropics, where UVBR is predicted to increase, the mosquito-borne dengue virus (DENV), is prevalent and a growing threat to humans. We therefore examined the effect of UVBR on the mosquito Aedes aegypti, the primary vector for DENV, to better understand the potential implications of increased tropical UVBR for mosquito-borne disease risk. We found that exposure to a UVBR dose that caused significant larval mortality approximately doubled the probability that surviving females would become infected with DENV, despite this UVBR dose having no effect on the expression of an effector gene involved in antiviral immunity. We also found that females exposed to a lower UVBR dose were more likely to have low fecundity even though this UVBR dose had no effect on larval size or activity, pupal cuticular melanin content, or adult mass, metabolic rate, or flight capacity. We conclude that future increases in tropical UVBR associated with anthropogenic global change may have the benefit of reducing mosquito-borne disease risk for humans by reducing mosquito fitness, but this benefit may be eroded if it also makes mosquitoes more likely to be infected with deadly pathogens.

Characterization of C30 carotenoid and identification of its biosynthetic gene cluster in Methylobacterium extorquens AM1

Methylobacterium species, the representative bacteria distributed in phyllosphere region of plants, often synthesize carotenoids to resist harmful UV radiations. Methylobacterium extorquens is known to produce a carotenoid pigment and recent research revealed that this carotenoid has a C30 backbone. However, its exact structure remains unknown. In the present study, the carotenoid produced by M. extorquens AM1 was isolated and its structure was determined as 4-[2-O-11Z-octadecenoyl-β-glucopyranosyl]-4,4′-diapolycopenedioc acid (1), a glycosylated C30 carotenoid. Furthermore, the genes related to the C30 carotenoid synthesis were investigated. Squalene, the precursor of the C30 carotenoid, is synthesized by the co-occurrence of META1p1815, META1p1816 and META1p1817. Further overexpression of the genes related to squalene synthesis improved the titer of carotenoid 1. By using gene deletion and gene complementation experiments, the glycosyltransferase META1p3663 and acyltransferase META1p3664 were firstly confirmed to catalyze the tailoring steps from 4,4′-diapolycopene-4,4′-dioic acid to carotenoid 1. In conclusion, the structure and biosynthetic genes of carotenoid 1 produced by M. extorquens AM1 were firstly characterized in this work, which shed lights on engineering M. extorquens AM1 for producing carotenoid 1 in high yield.

Optical imaging of in vivo adoptive T‐cell therapy: State of the art and challenges

AbstractAdoptive T‐cell therapy (ACT), which is an important type of live cell therapy, has achieved unprecedented success in treating hematological malignancies. Recent studies have shown that ACT is also a promising treatment for solid tumors. Visualizing the in vivo fates (distribution, homing, infiltration, proliferation, and exhaustion) of the immune cells used for ACT (ACT immune cells) is of great importance to promote basic research and clinical translation of ACT. Optical imaging techniques, including bioluminescence, fluorescence, and photoacoustic imaging, have the advantages of high sensitivity, high spatiotemporal resolution, minimal exposure to harmful radiation, and simple instrumentation. Recently, various types of optical imaging probes, including bioluminescence, fluorescence, and photoacoustic imaging probes, have been used to visualize ACT immune cells in vivo and evaluate the molecular mechanism, efficacy, and side effects of ACT. In this review, the optical imaging probes and labeling methods that have been used for in vivo visualization of ACT immune cells are summarized, and the opportunities and challenges of using optical imaging to visualize ACT immune cells in vivo are discussed.

Implementing a Telehealth Shared Counseling and Decision-Making Visit for Lung Cancer Screening in a Veterans Affairs Medical Center.

Veterans suffer substantial morbidity and mortality from lung cancer. Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce mortality. Guidelines recommend counseling and shared decision-making (SDM) to address the benefits and harms of screening and the importance of tobacco cessation before patients undergo screening. We implemented a centralized LCS program at the Iowa City Veterans Affairs Medical Center with a nurse program coordinator (NPC)-led telephone visit. Our multidisciplinary team ensured that veterans referred from primary care met eligibility criteria, that LDCT results were correctly coded by radiology, and that pulmonary promptly evaluated abnormal LDCT. The NPC mailed a decision aid to the veteran and scheduled a SDM telephone visit. We surveyed veterans after the visit using validated measures to assess knowledge, decisional conflict, and quality of decision making. We conducted 105 SDM visits, and 91 veterans agreed to LDCT. Overall, 84% of veterans reported no decisional conflict, and 59% reported high-quality decision making. While most veterans correctly answered questions about the harms of radiation, false-positive results, and overdiagnosis, few knew when to stop screening, and most overestimated the benefit of screening and the predictive value of an abnormal scan. Tobacco cessation interventions were offered to 72 currently smoking veterans. We successfully implemented an LCS program that provides SDM and tobacco cessation support using a centralized telehealth model. While veterans were confident about screening decisions, knowledge testing indicated important deficits, and many did not engage meaningfully in SDM. Clinicians should frame the decision as patient centered at the time of referral, highlight the importance of SDM, and be able to provide adequate decision support.

High-Temperature Stability of Sensor Platforms Designed to Detect Magnetic Fields in a Harmful Radiation Environment

High-Temperature Stability of Sensor Platforms Designed to Detect Magnetic Fields in a Harmful Radiation Environment

Assessing the Knowledge, Attitude, Practice towards the Sun Exposure and the use of Sunscreen by the General Population in Makkah, Saudi Arabia

Context: Sunlight exposure is a major cause of melanoma and non-melanoma skin cancer (NMSC). The sunscreen use can reduce the risk of developing melanoma and NMSC. Purpose: To assess the knowledge, attitude, and practice of the general population of Makkah city, Saudi Arabia related to sun exposure and the use of sun protection. Methods and Material: The present study is a descriptive cross-sectional study including 577 participants from the general population of Makkah city, Saudi Arabia using an online pretested Arabic questionnaire designed via Google Forms. Results: More than three-quarters of the respondents (78.4%) stated that sun exposure is harmful; of these, 61.9% stated that tanning, pigmentation, burns, skin cancer, and aging are potential risks that result from sun exposure. Further, 39.5% of the participants sometimes used sunscreen, while 23.9% of them regularly used sunscreen when exposed to the sun; the majority (75.1%) was unaware of the different forms of sunscreens. The factors associated with the regular use of sunscreen were female gender, aged between 18-25 years, and single. The majority of the respondents admitted that sunscreen use is necessary for protection against harmful ultraviolet radiation (88.9%); however, only 34.7% of them used other protective methods such as avoiding exposure to the sun (84.0%) and seeking shade (72.0%). Conclusions: According to the results, various attitudes toward the usage of sunscreen were found. Most of the respondents believed that exposure to the sun are harmful. However, the rate of sunscreen use by our population was average despite their reasonable awareness of the effects of sun exposure. This implies the need for health education campaigns and programs.

Ultrasonography in Pain Medicine and Regional Anesthesia Expert Consensus

Ultrasound has revolutionized interventional pain medicine and regional anesthesia. It allows visualization of nervoussystem structures, which are the primary targets in pain management and regional anesthesia procedures. Precise andsafe deposition of local anesthetics around nerve structures is made possible with ultrasound, resulting in rapid regionalanesthesia and modulation of pathological pain signals. In diagnostic and prognostic pain treatments, the precisionof drug administration and deposition of small volumes are crucial. Proper identification of the nerve responsible fortransmitting pathological pain signals is key to achieving the desired effect in neurodestructive procedures such asneurolysis, cryoablation, thermocoagulation, or pulsed neuromodulation. Visualization of structures to avoid, such asblood vessels or parenchymal organs, reduces the risk of adverse events like hematoma or damage to sensitive internalorgans. Real-time needle tracking during procedures shortens the duration and increases precision. Monitoring thespread of the administered therapeutic substance during the procedure enhances the effectiveness and selectivityof the block. When combined with X-ray imaging, using ultrasound reduces procedure time and exposure to X-rayradiation. Furthermore, ultrasound does not expose clinicians and patients to harmful X-ray radiation. Widespreadadoption of ultrasound in imaging nervous system structures during regional anesthesia and interventional painprocedures necessitates the development of new procedural standards.

Study to establish fiberoptic laryngoscopy as a diagnostic and investigation tool for laryngotracheal stenosis and to use the same for prognosis of the disease: retrospective analysis

Background: Laryngotracheal stenosis is a common benign condition of airway obstruction in both the pediatric and adult age group. This could either be acquired or congenital, in which there is narrowing of either the portions of the larynx or trachea making it difficult to breathe. This condition can be managed by several operative and endoscopic procedures. Flexible fiber optic laryngoscope is an excellent tool in the diagnostic investigation of laryngotracheal stenosis. Methods: This is a retrospective study that was done with data collected from the medical records department of patients diagnosed with laryngotracheal stenosis in a tertiary care hospital in the last 10 years. Results: A total of 22 patients who underwent FFL exam were taken for this retrospective study and the results were analyzed. Conclusions: This study proves that Fiberoptic laryngoscopy is a single modality diagnostic tool, which is useful in diagnosing, and localizing stenotic lesions in the Laryngotracheal region. It is cheap, less invasive and trained Otolaryngologist can perform this as an outpatient procedure. This therefore reduces the exposure to harmful radiation caused by repeated computed tomography scans.

Inhibitory Effects of Polyphenol- and Flavonoid-Enriched Rice Seed Extract on Melanogenesis in Melan-a Cells via MAPK Signaling-Mediated MITF Downregulation.

Melanin production is an important process that prevents the host skin from harmful ultraviolet radiation; however, an overproduction of melanin results in skin diseases. In the present study, we determined the antioxidative and anti-melanogenic activities of polyphenol- and flavonoid-enriched rice seed extracts in melan-a cells. The polyphenol and flavonoid content of Hopum (HP) and Sebok (SB) rice seed extracts was measured. The antioxidant capacity was determined using the ABTS radical scavenging method. SB contained high amounts of polyphenols and flavonoids, which significantly increased antioxidative activity compared with HP. Various concentrations of these extracts were evaluated in a cytotoxicity using melan-a cells. At 100 µg/mL, there was no significant difference for all treatments compared with untreated cells. Therefore, 100 µg/mL was selected as a concentration for the further experiments. SB significantly suppressed the phosphorylation/activation of p-38 MAPK, increased the expression of phosphorylated ERK 1/2 and Akt, and downregulated the microphthalmia-associated transcription factor (MITF). This resulted in decreased levels of tyrosinase and tyrosinase-related protein-1 and -2. These results indicate the potential of polyphenol- and flavonoid-enriched rice seed as a treatment for hyperpigmentation.

Performance Evaluation of a Magnetic Resonance Imager with Evidence-Based Decision Making Tools.

Evidence-based decision-making tools were used to evaluate the performance of a 16-year-old 1.5T Magnetic Resonance Imager (MRI) that has been fully dedicated to clinical service in a public hospital in Mexico. The MRI age highlights the importance of regular performance evaluations to ensure that the equipment is still functioning optimally, even when the system went through an important software and hardware updated. The use of Multiple-Criteria Decision-Making is an effective method to evaluate the performance of complex systems like MR imagers. A technical global indicator was set, revealing that only 50% of available time has been used is interesting and could be further investigated to determine if there are any factors limiting the usage of the system. The good performance indicators in terms of productivity, availability, and technical aspects are encouraging and suggest that the updated software and hardware have had a positive impact on the overall performance of the system.Finally, the use of evidence-based decision-making tools to evaluate the performance of the MR imager was a successful approach and can serve as a model for other healthcare facilities to follow.Clinical Relevance- MRI is a non-invasive diagnostic test that uses a magnetic field and radiofrequency waves to obtain detailed images of internal structures of the body. Unlike X-rays and CT scans, which use ionizing radiation, MRI does not expose patients to harmful radiation, making it a safe option for diagnostic imaging. The use of MRI a valuable tool for characterizing lesions, detecting abnormalities, and monitoring disease progression and it is widely used in several medical fields, including neurology, oncology, and orthopedics, among others. Therefore, ensuring that the MRI system is working optimally is crucial for providing reliable and accurate results, which can lead to timely and appropriate treatment for patients.

Optimization design generation of the rural residential building towards energy saving by using “Digital intelligence” technology

Based on the “Digital Intelligence” technology, the scheme of building design can be automatically generated and optimized simultaneously. However, this method has not been reported, in terms of the optimization design generation by improving the building energy saving potential for the rural residential building. Here, according to the data of floor plans of the rural residential buildings collected from the hot summer and cold winter climate region (China), five types of floor plans were deduced. Firstly, we proposed the method of comprehensive score and weight assignment to achieve the optimum functional layout, according to evaluation indicators of the sum of the helpful and harmful radiations, the energy consumptions corresponding to the individual rooms in various spatial positions and the functional layout characters in the study region. Secondly, the plan configuration was also taken into account to improve the energy saving potential of design building, by using the evaluation indicator of plan-shaped coefficient. Based on the criteria of functional layout and plan configuration, the optimum modes for the five types of floor plans were derived. Thirdly, the component parameters of individual rooms in the design building were optimized by genetic algorithm. This study reveals the principle of the automatic generation of building design in synchronicity with improvement of its energy saving potential, and provides an achievement approach to the strategy of “rural revitalization” and the goal of “carbon peaking and carbon neutrality” in China.