The radiant heating is cost effective way of space heating while providing favourable thermal comfort. Due to the large thermal flexibility, it is possible to utilize the pipe embedded radiant heating for low-temperature heating and demand management, thereby giving more access to the low-grade heat sources such as the renewable energy or the industrial waste heat. In this study, we investigate the optimal configuration of the radiant floor heating system considering different district heating (DH) scenarios. We propose the scheduled control strategy considering the comfort requirements, the occupancy and the dynamic energy price. Parametric simulations regarding the pipe spacing, the thickness of the concrete core, and the DH supply temperatures are performed by Modelica models. The critical levels of the radiant floor configurations of applying medium-temperature DH (MTDH), low-temperature DH (LTDH) and ultra-low temperature DH (ULTDH) are investigated. The indoor comfort, the thermal performances, the economy performances and the energy flexibility as the crucial factors of different cases are analysed and compared. The results show that the pipe spacing of 300 mm achieves better comfort and shorter charging time for all DH scenarios of the case nearly zero energy building (NZEB). The larger thickness of the concrete core can stabilize the indoor temperature variation and buffer the impact from the environmental disturbance more effectively.