To evaluate the influence of aging on the fracture load (Lf) and reliability of glass-ceramics after different etching protocols. Specimens were fabricated and divided according to the etching Ame (10% hydrofluoric acid [HF] for 20 seconds, 40 seconds, and 60 seconds). Etched surfaces were examined under microscopy. The ceramics were resin-cemented to a dentin analog material. Samples were split into two groups (n = 20 each) and tested after 24 hours (I) or stored in 37° water for 1 year (A). A compressive load (0.1 mm/minute) was applied to the samples unAl failure was detected by acoustic emission. The influence of aging on the Lf was tested by two-way ANOVA and Tukey tests (α = .05). The characteristic fracture load (L0) and Weibull modulus (m) values were calculated. Lithium silicate (LS) etching for 20 seconds resulted in the highest immediate Lf, which was significantly decreased after aging (P ≤ .05). Water storage had no effect on the Lf of glass-ceramic etched for 40 and 60 seconds (P > .05). For lithium disilicate (LD), the etching time had no significant effect on the immediate or aged Lf (P > .05). The Lf was significantly reduced after aging (A) for LD (P ≤ .05). Radial cracks were the predominant failure mode. Surface topography was more regular after lower etching times for LD and after higher times for LS. After 1 year of water-assisted aging, the evaluated etching times had no influence on the load-bearing capacity and structural reliability of resin-bonded glass-ceramics.