The flow rate is a significant factor in the operation of centrifugal pumps. The characteristic curve of the pump head is frequently employed in the calculation of the flow rate. Nevertheless, this may be subject to alteration because of prewhirl on the suction side of the pump. Calculating the changes in the head’s characteristic curve reveals a change in hydraulic losses. The impact of prewhirl on hydraulic losses is investigated by experimental and numerical analysis of two radial centrifugal pumps. It is demonstrated that the primary changes occur in the pump impeller losses. Relative velocity is a significant factor in this context. Alterations in the pumps’ configurations result in a range of secondary flows and shock losses at the leading edge of the blades. A physical model, derived on the basis of the relative velocity, is used to predict the characteristic curves of radial centrifugal pumps with prewhirl with a high degree of accuracy. The results demonstrate a notable enhancement in comparison to modelling techniques that do not incorporate the fluctuating hydraulic losses.