Radcliffe Infirmary Research Articles

Peripheral T-Cell Lymphoma Associated with Hemophagocytic Syndrome

Abstract Nine patients with an acute disease characterized by high fever, loss of weight, prominent hepatosplenomegaly, slight or no lymphadenopathy, abnormal liver function tests, and profound pancytopenia are reported. In all cases, the disease presented in the absence of any pre-existing disease or immunosuppressive therapy. In seven of the nine patients, survival was very short (mean = 7 weeks). Two patients are still alive: one had a relapse 24 months after the initial diagnosis, while the other is in complete remission. The main pathological feature was the infiltration of the marrow, spleen and liver by neoplastic T cells, accompanied by an exuberant hyperplasia of benign-looking, hemophagocytizing histiocytes. The term “peripheral T-cell lymphoma with hemophagocytic syndrome” is proposed for this condition. Retrospective analysis of stored paraffin material (1949 to 1965) from the Radcliffe Infirmary files suggests that at least some of the cases designated as “histiocytic medullary reticulosis” by Scott and Robb- Smith were examples of the syndrome herein described.

Aetiology and pathogenesis of ulcerative colitis and Crohn’s disease

Journal Article Aetiology and pathogenesis of ulcerative colitis and Crohn’s disease Get access D P Jewell D P Jewell Gastroenterology Unit, The Radcliffe Infirmary, Oxford OX2 6HE, UK Correspondence: D.P. Jewell M.A., D.Phil., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar Postgraduate Medical Journal, Volume 65, Issue 768, October 1989, Pages 718–719, https://doi.org/10.1136/pgmj.65.768.718 Published: 01 October 1989 Article history Received: 16 May 1989 Published: 01 October 1989

Lung cancer and passive smoking: Predicted effects from a mathematical model for cigarette smoking and lung cancer : Darby SC, Pike MC. Clinical Trials Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford OX2 6HE. Br J Cancer 1988;58:825-31

Lung cancer and passive smoking: Predicted effects from a mathematical model for cigarette smoking and lung cancer : Darby SC, Pike MC. Clinical Trials Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford OX2 6HE. Br J Cancer 1988;58:825-31

A cohort study of controlled trials initially reported as abstracts: I. Chalmers, C.L. Meinert, T.C. Chalmers, M.E. Adams, S. Tonascia, J. Hetherington, W. Tarnow-Modi The National Perinatal Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford, England(09)

A cohort study of controlled trials initially reported as abstracts: I. Chalmers, C.L. Meinert, T.C. Chalmers, M.E. Adams, S. Tonascia, J. Hetherington, W. Tarnow-Modi The National Perinatal Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford, England(09)

Ceroid‐lipofuscinoses—Batten disease and allied disorder. J. M. Opitz, R. K. Pullarkat, J. F. Reynolds and L. M. Spano (Eds). Alan R. Liss, New York, 1988. No. of pages: 307 + x. Price: 85.00. ISBN: 08451 4251 8

The Journal of PathologyVolume 159, Issue 1 p. 92-92 Book Review Ceroid-lipofuscinoses—Batten disease and allied disorder. J. M. Opitz, R. K. Pullarkat, J. F. Reynolds and L. M. Spano (Eds). Alan R. Liss, New York, 1988. No. of pages: 307 + x. Price: 85.00. ISBN: 08451 4251 8 M. V. Squier, M. V. Squier The Radcliffe Infirmary, OxfordSearch for more papers by this author M. V. Squier, M. V. Squier The Radcliffe Infirmary, OxfordSearch for more papers by this author First published: September 1989 https://doi.org/10.1002/path.1711590119AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume159, Issue1September 1989Pages 92-92 RelatedInformation

Radcliffe infirmary gets uniform opinions

Radcliffe infirmary gets uniform opinions

The obstetric vacuum extractor is the instrument of first choice for operative vaginal delivery.

BJOG: An International Journal of Obstetrics & GynaecologyVolume 96, Issue 5 p. 505-506 The obstetric vacuum extractor is the instrument of first choice for operative vaginal delivery J. A. Chalmers, J. A. Chalmers 44 Observatory Street Oxford OX2 6EPSearch for more papers by this authorI. Chalmers, I. Chalmers National Perinatal Epidemiology Unit Radcliffe Infirmary Oxford OX2 6HESearch for more papers by this author J. A. Chalmers, J. A. Chalmers 44 Observatory Street Oxford OX2 6EPSearch for more papers by this authorI. Chalmers, I. Chalmers National Perinatal Epidemiology Unit Radcliffe Infirmary Oxford OX2 6HESearch for more papers by this author First published: May 1989 https://doi.org/10.1111/j.1471-0528.1989.tb03246.xCitations: 81AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume96, Issue5May 1989Pages 505-506 RelatedInformation

Closing regrets

In the discussion about the closure of the Oxford Nursing Development Unit Ward (Beeson) at the Radcliffe Infirmary, it was implied that one of the reasons for the closure was opposition from medical staff. As the Consultant Physician Advisor to the unit whose medical staff provided the medical care and cover when required, I found that the standard of nursing provided by the team was extremely high.

General nutrition

Department of Geriatric Medicine, Radcliffe Infirmary, Oxford, and Gastrointestinal Unit, Western General Hospital, Edinburgh, UK

A reply

AnaesthesiaVolume 44, Issue 4 p. 364-364 Free Access A reply J.M. Miller, J.M. Miller The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author J.M. Miller, J.M. Miller The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author First published: April 1989 https://doi.org/10.1111/j.1365-2044.1989.tb11319.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume44, Issue4April 1989Pages 364-364 RelatedInformation

Postoperative Orthopaedic Pain— The Effect of Opiate Premedication and Local Anaesthetic Blocks

Oxford Regional Pain Relief Unit and Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, United Kingdom Pain, 33: 291–295, 1988

The Value of Immunocytochemistry in Differentiating High-Grade: Lymphoma from Other Anaplastic Tumours: A study of anaplastic tumours from 1940 to 1960

Immunocytochemistry is now established in many histology laboratories for diagnostic purposes and is routinely used in ascribing an origin to poorly differentiated tumours. This raises the question of whether traditional morphological skills are being abandoned in favour of new technology and, if so, whether that is justified. Twenty-three lymph node biopsies diagnosed as anaplastic carcinoma, reticulosarcoma or unclassifiable tumour between 1940 and 1960 (when immunocytochemistry was not available) were retrieved from the archives of the Radcliffe Infirmary. Paraffin sections were stained with a panel of monoclonal antibodies previously shown to be useful in the identification of tumours of uncertain origin. Of the 15 cases given a definite morphological diagnosis six (40%) were shown to be incorrect on the basis of immunostaining. In the eight remaining cases in which no diagnosis was recorded immunostaining provided a clear diagnosis in seven instances. These results are similar to those recorded on contemporary cases and demonstrate the value of immunocytochemical staining, as an adjunct to traditional morphological examination. In addition, it is clear that currently available monoclonal antibodies are suitable for use on routinely processed material more than 30 years old.

Incidence and consequences of ejection in motor vehicle accidents.

This article described the results of a comparison of the severity of injury and number of deaths between completely ejected and non ejected motor vehicle occupants. Information was collected between January 1983 and January 1985 on all patients injured in road traffic accidents in the catchment area of john radcliffe hospital, oxford. Injuries were coded by region and scored using the abbreviated injury scale. Altogether 1550 vehicle occupants were injured (871 drivers, 375 front seat passengers, and 304 rear seat passengers). Forty five were completely ejected from the vehicle in the accident (11 drivers, 9 front seat passengers and 25 rear seat passengers). The incidence of ejection was 2.9% overall. It was lower for drivers (1.2%) and front seat passengers (2.4%) but significantly higher for rear seat passengers (8.2%). Being ejected was associated with a significantly greater incidence of severe or critical injuries, and a higher incidence of fatal injuries. None of the ejected rear seat passengers was wearing a seat belt. Of the 834 occupants known to be wearing seat belts, only 5 were ejected. Ejection occurred most commonly in accidents at high speeds and those in which the vehicle rolled over.

Voice restoration following total laryngectomy

International Journal of Clinical PracticeVolume 42, Issue 5 p. 190-191 Clinical Study Voice restoration following total laryngectomy N P Warwick-Brown FRCS, Corresponding Author N P Warwick-Brown FRCS n/[email protected] Department of Otolaryngology, Charing Cross Hospital, LondonAddress correspondence to Mr N P Warwick-Brown, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE.Search for more papers by this authorA Perry LCST, A Perry LCST Department of Otolaryngology, Charing Cross Hospital, LondonSearch for more papers by this authorA D Cheesman FRCS, A D Cheesman FRCS Department of Otolaryngology, Charing Cross Hospital, LondonSearch for more papers by this author N P Warwick-Brown FRCS, Corresponding Author N P Warwick-Brown FRCS n/[email protected] Department of Otolaryngology, Charing Cross Hospital, LondonAddress correspondence to Mr N P Warwick-Brown, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE.Search for more papers by this authorA Perry LCST, A Perry LCST Department of Otolaryngology, Charing Cross Hospital, LondonSearch for more papers by this authorA D Cheesman FRCS, A D Cheesman FRCS Department of Otolaryngology, Charing Cross Hospital, LondonSearch for more papers by this author First published: 01 May 1988 https://doi.org/10.1111/j.1742-1241.1988.tb08549.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume42, Issue5May 1988Pages 190-191 RelatedInformation

Inspired monitoring

AnaesthesiaVolume 43, Issue 2 p. 169-169 Free Access Inspired monitoring I. Sivakoluntho, I. Sivakoluntho The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this authorC.E. Blogg, C.E. Blogg The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author I. Sivakoluntho, I. Sivakoluntho The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this authorC.E. Blogg, C.E. Blogg The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author First published: February 1988 https://doi.org/10.1111/j.1365-2044.1988.tb05522.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 Mathias JA, Lunn JN. Minimal monitoring and vigilance. Anaesthesia 1987; 42: 683– 4. 2 Sykes MK. Essential monitoring. British Journal of Anaesthesia 1987; 59: 901– 12. Volume43, Issue2February 1988Pages 169-169 ReferencesRelatedInformation

Passage of nasogastric tubes

AnaesthesiaVolume 43, Issue 2 p. 168-168 Free Access Passage of nasogastric tubes M.K. Sykes, M.K. Sykes The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author M.K. Sykes, M.K. Sykes The Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author First published: February 1988 https://doi.org/10.1111/j.1365-2044.1988.tb05519.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume43, Issue2February 1988Pages 168-168 RelatedInformation

An international survey to identify unpublished and ongoing perinatal trials: Jini Hetherington The Project on Publication Bias in Clinical Trials, National Perinatal Epidemiology Unit, Radcliffe Infirmary, Oxford, England, Johns Hopkins School of Public Health and Harvard School of Public Health(23)

An international survey to identify unpublished and ongoing perinatal trials: Jini Hetherington The Project on Publication Bias in Clinical Trials, National Perinatal Epidemiology Unit, Radcliffe Infirmary, Oxford, England, Johns Hopkins School of Public Health and Harvard School of Public Health(23)

Cryptorchidism: An apparent substantial increase since 1960: John radcliffe hospital cryptorchidism study group. Br Med J 293:1401–1404, (November), 1986

Cryptorchidism: An apparent substantial increase since 1960: John radcliffe hospital cryptorchidism study group. Br Med J 293:1401–1404, (November), 1986

Recent avances in neuropathology, number 3. J. B. Cavanagh (Ed.) Churchill Livingstone, 1986. No. of pages: viii + 167. Price: £30.00. ISBN: 0 443 0322 62

The Journal of PathologyVolume 152, Issue 2 p. 138-138 Book Review Recent avances in neuropathology, number 3. J. B. Cavanagh (Ed.) Churchill Livingstone, 1986. No. of pages: viii + 167. Price: £30.00. ISBN: 0 443 0322 62 M. M. Esiri, M. M. Esiri Radcliffe Infirmary, OxfordSearch for more papers by this author M. M. Esiri, M. M. Esiri Radcliffe Infirmary, OxfordSearch for more papers by this author First published: June 1987 https://doi.org/10.1002/path.1711520213AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume152, Issue2June 1987Pages 138-138 RelatedInformation

A way forward for intensive care

AnaesthesiaVolume 42, Issue 5 p. 552-552 Free Access A way forward for intensive care C.R. Blakeley, C.R. Blakeley Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author C.R. Blakeley, C.R. Blakeley Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford OX2 6HESearch for more papers by this author First published: May 1987 https://doi.org/10.1111/j.1365-2044.1987.tb04057.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume42, Issue5May 1987Pages 552-552 RelatedInformation