Rabies control programs include preventive immunization of farm and domestic animals, catching stray dogs and cats, oral vaccination of wild animals, and measures to control the number of the wildlife. Rabies in ruminants is a deadlock in the rabies epizootic situation. Rabies in ruminant animals is the result of the epizootic process in wild animals of the area, even if the process is not recorded. The more than doubled decrease in the number of cattle the European part of Russia saw in recent years resulted in a decrease in cases of rabies in these animals. Vaccination forms the animal group that prevents the further spread of infection, and further reduces morbidity. The paper presents the data on the rabies epizootic situation on the territory of Tatarstan in 2018, preventive measures against the epizootic situation among domestic, wild and farm animals. Also, it presents laboratory results of blood 51 DOI: 10.31563/1684-7628-2019-51-3-48-52 Вестник БГАУ / Vestnik BSAU, 2019, № 3 serum samples in the cattle vaccinated against rabies in some areas of Tatarstan and border areas of Bashkortostan. The study results indicate that both regions take effective measures against rabies. The incidence of rabies in farm animals is minimized due to a large number of vaccinated animals, and preventive measures taken against rabies among wild animals. Revaccination of cattle is needed in a number of areas to ensure better protection of animals.