Administration Of Quinacrine Research Articles

Chloroquine for Chronic Discoid Lupus Erythematosus

It is not unusual to see one, or perhaps a few residual lesions of various dermatoses which have failed to respond to an otherwise successful regimen of therapy. 1 Examples are the persistent penile plaque of distinctive exudative discoid and lichenoid chronic dermatosis (Sulzberger-Garbe), the single or few persistent lesions of psoriasis, lichen planus, pemphigus, discoid lupus erythematosus, and others. This report concerns primarily the residual lesions of chronic discoid lupus erythematosus. It is well known that isolated lesions of chronic discoid lupus erythematosus may be treated by various local applications, e.g., various acids, solid carbon dioxide, and the intralesional injection of gold compounds. 2,3 Recently, we became interested in the report of Ottolenghi-Lodigiani, 4 on the combined intralesional and oral administration of quinacrine (Atabrine) and the report of Thies, 5 on the favorable effects of chloroquine used intralesionally as well as systemically. For our purposes, chloroquine dichloride, 50 mg.

Recent advances in nutrition and metabolism. II. Review of the literature on vitamins, 1952.

A SMALL monograph entitled Present Knowledge in Nutrition has been published recently. 1 This should prove a most useful reference; sections dealing with calories, protein, fat, carbohydrate, minerals, and vitamins are included. VITAMIN A Cama and associates * reported further studies of the characteristics of vitamin A and related compounds. Kaiser and Kagan 6 have described a technique for the determination of vitamin A in feces. Prolonged administration of quinacrine (Atabrine) to rats was found to result in damage to the liver and impairment of the ability of this organ to store vitamin A. Absorption of vitamin A and carotene was depressed by the drug. 7 The administration of excessive amounts of vitamin A to rats and other animals accelerates the growth and maturation of epiphyseal cartilage cells and the remodeling process which accompanies bone growth. Such effects are suggestive of hormonal action, possibly that of the anterior pituitary. However, studies

HEMATOLOGICAL CHANGES FOLLOWING THE ADMINISTRATION OF LARGE DOSES OF QUINACRINE HYDROCHLORIDE

AbstractThe administration of quinacrine to rats, mice, rabbits, hamsters, guinea-pigs, dogs, monkeys, chickens, and ducks results in definite hematological changes. Peculiar basophilic inclusions, usually associated with vacuoles, appear in the cytoplasm of lymphocytes of all nine species following drug therapy. Inclusions of a similar nature are seen in erythrocytes of the rat, mouse, and hamster and rarely in monocytes of the rat.The rat shows an anemia, polynucleosis, lymphopenia, and monocytosis after quinacrine dosing. None of the other species develop a leukocytosis or monocytosis, but they sometimes show a polynucleosis and lymphopenia after quinacrine therapy. Leukopenia occurs in the monkey and occasionally in the dog following the use of this drug.