Quiescent Samples Research Articles

Environmental Dependence of Type Ia Supernovae in Low-redshift Galaxy Clusters

We present an analysis of 102 Type Ia supernovae (SNe Ia) in nearby (z < 0.1), x-ray-selected galaxy clusters. This is the largest such sample to date and is based on archival data primarily from ZTF and ATLAS. We divide our SNe Ia into an inner cluster sample projected within r 500 of the cluster center and an outer cluster sample projected between r 500 and 2 r 500. We compare these to field samples of SNe Ia at similar redshifts in both quiescent and star-forming host galaxies. Based on SALT3 fits to the light curves, we find that the inner cluster SNe Ia have a higher fraction of fast-evolving objects (SALT3 x 1 < −1) than the outer cluster or field quiescent samples. This implies an intrinsically different population of SNe Ia occurs in inner cluster environments, beyond known correlations based on host galaxy alone. Our cluster samples show a strongly bimodal x 1 distribution with a fast-evolving component that dominates the inner cluster objects (≳75%) but is just a small fraction of SNe Ia in field star-forming galaxies (≲10%). We do not see strong evidence for variations in the color (SALT3 c) distributions among the samples and find only minor differences in SN Ia standardization parameters and Hubble residuals. We suggest that the age of the stellar population drives the observed distributions, with the oldest populations nearly exclusively producing fast-evolving SNe Ia.

Analysis of the transcriptional pathways associated with the induction of quiescent embryonic arrest in the calanoid copepod Acartia tonsa

The copepod species Acartia tonsa (Dana)(Crustacea) have the unique ability to induce quiescent embryonic dormancy if adverse environmental conditions occur; a characteristic shared by 41 other species belonging to the superfamily Centropagoida in the Calanoida order. However, the transcriptional changes characterizing this process are not known. Here, we compare the transcriptome of embryos in arrested quiescence with the normal development to identify pathways and differentially regulated transcripts involved in quiescent embryogenesis. Quiescence was induced by incubating eggs at 4 °C with anoxia for 26 h(hr), while eggs undergoing normal immediate development were incubated at 16.9 °C in normoxia for 7 h (where gastrulation occurs) or 14 h (where organogenesis occurs) before collecting for RNA extraction and analysis by RNA-sequencing. Results indicate that the expression profile of the quiescent embryo is not as different from the normal embryonic gastrulation as initially expected: None of the mapped transcripts is uniquely expressed in quiescence. Moreover, in quiescence a large proportion of the annotated transcripts display expression values halfway in-between the normal, immediate developmental stages of gastrulation and organogenesis. In depth comparison between the organogenesis stage and quiescent samples, reveal a high degree of divergence, confirming that a developmental arrest has been induced through quiescence. Specifically: Stress response transcripts are prominent in the quiescent phase with a transcript like the mammalian autophagy gene Sequestosome-1/p62 (SQSTM) being upregulated. The present analysis provides a better understanding of the molecular mechanisms characterizing the quiescent embryonic state of A. tonsa.

Beyond UVJ: Color Selection of Galaxies in the JWST Era

We present a new rest-frame color–color selection method using synthetic u s − g s and g s − i s , (ugi) s colors to identify star-forming and quiescent galaxies. Our method is similar to the widely used U − V versus V − J (UVJ) diagram. However, UVJ suffers known systematics. Spectroscopic campaigns have shown that UVJ-selected quiescent samples at z ≳ 3 include ∼10%–30% contamination from galaxies with dust-obscured star formation and strong emission lines. Moreover, at z > 3, UVJ colors are extrapolated because the rest-frame band shifts beyond the coverage of the deepest bandpasses at <5 μm (typically Spitzer/IRAC 4.5 μm or future JWST/NIRCam observations). We demonstrate that (ugi) s offers improvements to UVJ at z > 3, and can be applied to galaxies in the JWST era. We apply (ugi) s selection to galaxies at 0.5 < z < 6 from the (observed) 3D-HST and UltraVISTA catalogs, and to the (simulated) JAGUAR catalogs. We show that extrapolation can affect (V − J)0 color by up to 1 mag, but changes color by ≤0.2 mag, even at z ≃ 6. While (ugi) s -selected quiescent samples are comparable to UVJ in completeness (both achieve ∼85%–90% at z = 3–3.5), (ugi) s reduces contamination in quiescent samples by nearly a factor of 2, from ≃35% to ≃17% at z = 3, and from ≃60% to ≃33% at z = 6. This leads to improvements in the true-to-false-positive ratio (TP/FP), where we find TP/FP ≳2.2 for (ugi) s at z ≃ 3.5 − 6, compared to TP/FP < 1 for UVJ-selected samples. This indicates that contaminants will outnumber true quiescent galaxies in UVJ at these redshifts, while (ugi) s will provide higher-fidelity samples.

The relationship between galaxy and halo sizes in the Illustris and IllustrisTNG simulations

ABSTRACT Abundance matching studies have shown that the average relationship between galaxy radius and dark matter halo virial radius remains nearly constant over many orders of magnitude in halo mass, and over cosmic time since about z = 3. In this work, we investigate the predicted relationship between galaxy radius re and halo virial radius Rh in the numerical hydrodynamical simulations Illustris and IllustrisTNG from z ∼ 0–3, and compare with the results from the abundance matching studies. We find that Illustris predicts much higher re/Rh values than the constraints obtained by abundance matching, at all redshifts, as well as a stronger dependence on halo mass. In contrast, IllustrisTNG shows very good agreement with the abundance matching constraints. In addition, at high redshift it predicts a strong dependence of re/Rh on halo mass on mass scales below those that are probed by existing observations. We present the predicted re/Rh relations from Illustris and IllustrisTNG for galaxies divided into star forming and quiescent samples, and quantify the scatter in re/Rh for both simulations. Further, we investigate whether this scatter arises from the dispersion in halo spin parameter and find no significant correlation between re/Rh and halo spin. We investigate the paths in re/Rh traced by individual haloes over cosmic time, and find that most haloes oscillate around the median re/Rh relation over their formation history.

Platelet-rich plasma and ovarian quiescence: a bovine in vitro model for regeneration of the ovary.

Ovarian quiescence can be due to hormonal deficiency usually caused by apoptosis of granulosa cells responsible for oestrogen synthesis. This study evaluated the regenerative effect of platelet rich plasma (PRP) on bovine in vitro models to understand its effect on granulosa cells. Quiescent and healthy ovarian sections were cultured in the presence/absence of PRP for 72h and, at different times (0, 24, 48 and 72h), hematoxylin-eosin and immunohistochemical detection of Ki-67 were performed. Additionally, granulosa cells collected from healthy bovine ovaries were stressed with 100ng/mL of lipopolysaccharide (LPS) in presence/absence of PRP and evaluated at 0, 4, 8 and 24h for apoptosis by acridine orange and propidium iodide staining. Enzyme-linked immunosorbent assay tests were performed to evaluate oestrogen (E2) and anti-Müllerian hormone (AMH) concentrations on cultures of ovarian slices and granulosa cells. In slides of quiescent ovaries treated with PRP, a marked and widespread positivity to Ki-67 was expressed by 40-60% of the follicular wall cells at 48h of culture. Levels of E2 and AMH were significantly higher compared to untreated quiescent samples reaching the levels of healthy control samples. PRP counteracted the LPS effect and apoptosis (at 24h, there were 93.44±3.51% live cells with LPS+PRP compared to 37±1.32% with LPS) and significantly increased concentrations of E2 and AMH. PRP can stimulate granulosa cell proliferation and counteract inflammatory processes in vitro . This treatment could improve the reproductive ability of quiescent females.

Massive quiescent galaxies at z ∼ 3: A comparison of selection, stellar population, and structural properties with simulation predictions

ABSTRACT We study stellar population and structural properties of massive log (M⋆/M⊙) &amp;gt; 11 galaxies at z ≈ 2.7 in the Magneticum and IllustrisTNG hydrodynamical simulations and GAEA semi-analytic model. We find stellar mass functions broadly consistent with observations, with no scarcity of massive, quiescent galaxies at z ≈ 2.7, but with a higher quiescent galaxy fraction at high masses in IllustrisTNG. Average ages of simulated quiescent galaxies are between ≈0.8 and ${1.0\, \textrm {Gyr}}$, older by a factor ≈2 than observed in spectroscopically confirmed quiescent galaxies at similar redshift. Besides being potentially indicative of limitations of simulations in reproducing observed star formation histories, this discrepancy may also reflect limitations in the estimation of observed ages. We investigate the purity of simulated UVJ rest-frame colour-selected massive quiescent samples with photometric uncertainties typical of deep surveys (e.g. COSMOS). We find evidence for significant contamination (up to ${60\, \rm {per\, cent}}$) by dusty star-forming galaxies in the UVJ region that is typically populated by older quiescent sources. Furthermore, the completeness of UVJ-selected quiescent samples at this redshift may be reduced by $\approx {30\, \rm {per\, cent}}$ due to a high fraction of young quiescent galaxies not entering the UVJ quiescent region. Massive, quiescent galaxies in simulations have on average lower angular momenta and higher projected axis ratios and concentrations than star-forming counterparts. Average sizes of simulated quiescent galaxies are broadly consistent with observations within the uncertainties. The average size ratio of quiescent and star-forming galaxies in the probed mass range is formally consistent with observations, although this result is partly affected by poor statistics.

A novel role for Livin in the response to ultravioletB radiation and pterygium development.

A pterygium is an inflammatory, invasive and proliferative lesion on the ocular surface, which can decrease visual acuity, damage the ocular surface and affect the appearance of the eye. However, the underlying molecular mechanisms of the pathogenesis remain unclear. In the present study, the role of apoptosis-associated protein Livin in the occurrence and development of pterygium was investigated. Primary samples from quiescent or advanced clinical stages of pterygium and normal human conjunctival tissues were used to assess mRNA and protein expression levels of Livin using reverse transcription-quantitative PCR and immunohistochemistry, respectively. Livin was knocked down in pterygium epithelial cells (PECs) using small interfering RNA (siRNA), to investigate the role of Livin in PEC viability, migration, invasion ability and apoptosis. The cell viability, invasion ability and apoptosis of PECs following ultraviolet B (UVB) radiation alone or in combination with Livin silencing were also analyzed. Expression levels of Livin increased in the pterygium tissues compared with those in the normal conjunctiva at both the mRNA and protein levels. Livin expression levels in advanced pterygium were significantly higher compared with those in quiescent pterygium samples. Knockdown of Livin expression levels significantly reduced cell migration, invasion ability and cell viability, and induced apoptosis of PECs. Inhibition of Livin expression in PECs increased the expression levels of caspase-7, caspase-3 and E-cadherin, whereas expression levels of Snail were downregulated. Cell viability and invasion ability in PECs was enhanced following UVB radiation and Livin expression upregulated. UVB irradiation induced cell invasion ability of PECs and this was attenuated by Livin-silencing. Transfection with Livin siRNA also partially recovered the apoptosis rate of PECs, which was reduced by UVB irradiation. In conclusion, Livin was upregulated in pterygium, and UVB radiation functions in the development of pterygium by inducing Livin expression.

Black hole scaling relations of active and quiescent galaxies: Addressing selection effects and constraining virial factors

Local samples of quiescent galaxies with dynamically measured black hole masses (Mbh) may suffer from an angular resolution-related selection effect, which could bias the observed scaling relations between Mbh and host galaxy properties away from the intrinsic relations. In particular, previous work has shown that the observed Mbh-Mstar (stellar mass) relation is more strongly biased than the Mbh-sigma (velocity dispersion) relation. Local samples of active galactic nuclei (AGN) do not suffer from this selection effect, as in these samples Mbh is estimated from megamasers and/or reverberation mapping-based techniques. With the exception of megamasers, Mbh-estimates in these AGN samples are proportional to a virial coefficient fvir. Direct modelling of the broad line region suggests that fvir~3.5. However, this results in a Mbh-Mstar relation for AGN which lies below and is steeper than the one observed for quiescent black hole samples. A similar though milder trend is seen for the Mbh-sigma relation. Matching the high-mass end of the Mbh-Mstar and Mbh-sigma relations observed in quiescent samples requires fvir~15 and fvir~7, respectively. On the other hand, fvir~3.5 yields Mbh-sigma and Mbh-Mstar relations for AGN which are remarkably consistent with the expected `intrinsic' correlations for quiescent samples (i.e., once account has been made of the angular resolution-related selection effect), providing additional evidence that the sample of local quiescent black holes is biased. We also show that, as is the case for quiescent black holes, the Mbh-Mstar scaling relation of AGN is driven by velocity dispersion, thus providing additional key constraints to black hole-galaxy co-evolution models.

Structural transformations and mechanical properties of porous glasses under compressive loading

The role of porous structure and glass density in the response behavior to compressive deformation of amorphous materials is investigated via molecular dynamics simulations. The disordered, porous structures were prepared by quenching a high-temperature binary mixture below the glass transition point into the phase coexistence region. With decreasing average glass density, the pore morphology in quiescent samples varies from a random distribution of compact voids to complex pore networks embedded in a continuous glass phase. We find that during compressive loading at constant volume, the porous structure is linearly transformed in the elastic regime and the elastic modulus follows a power-law increase as a function of the average glass density. Upon further compression, pores deform significantly and coalesce into large voids leading to formation of domains with nearly homogeneous glass phase, which provides an enhanced resistance to deformation at high strain.

Strain-induced deformation of the porous structure in binary glasses under tensile loading

The evolution of porous structure and mechanical properties of binary glasses under tensile loading were examined using molecular dynamics simulations. We consider vitreous systems obtained in the process of phase separation taking place after a rapid isochoric quench of a glass-forming liquid to temperatures below the glass transition point. The porous structure in undeformed samples varies from a connected porous network to a random distribution of isolated pores with increasing average density. We find that the elastic modulus follows a power-law dependence on the average glass density and the shape of pore size distribution at small strain remains nearly the same as in quiescent samples. Upon further loading, the pores become significantly deformed and coalesce into larger voids that leads to formation of system-spanning empty regions associated with failure of the material.

An unusual promotion of γ-crystals in metallocene-made isotactic polypropylene from orientational relaxation and favorable temperature window induced by shear

Combined effects of shear flow and non-isothermal processing, which were akin to the practical industrial processing, on the crystallization of metallocene-made isotactic polypropylene (m-iPP) were investigated by in-situ synchrotron wide-angle X-ray diffraction (WAXD) and small-angle X-ray scattering (SAXS) techniques. The simultaneous appearance of α- and γ-crystals was observed in quiescent samples, while shear flow led to the occurrence of α-crystals prior to γ-crystals at the initial stage of crystallization. Although the local alignment of chain segments promoted by shear flow facilitated the α-crystals, the relaxation of oriented chains was experimentally confirmed to boost the formation of γ-crystals. Interestingly, the resultant γ-crystal content was higher in the sheared samples than the quiescent counterparts at a given cooling rate and further increased with the decrease of cooling rates. Such a discrepancy was not only related to shear-induced orientation and relaxation, but also was accredited to the advanced crystallization temperature window, which was favorable for the γ-crystal growth. It was quite different from the isothermal crystallization situation, where the formation of γ-crystals was depressed in presence of shear flow. The dynamic competition between α-crystal and γ-crystal formation under the effects of shear during the non-isothermal crystallization was discussed. Our work is of valuable reference to tailor the crystalline structure of m-iPP during practical processing and hence to acquire the desired performance of products.

Evolution of the pore size distribution in sheared binary glasses.

Molecular dynamics simulations are carried out to investigate mechanical properties and porous structure of binary glasses subjected to steady shear. The model vitreous systems were prepared via thermal quench at constant volume to a temperature well below the glass transition. The quiescent samples are characterized by a relatively narrow pore size distribution whose mean size is larger at lower glass densities. We find that in the linear regime of deformation, the shear modulus is a strong function of porosity, and the individual pores become slightly stretched while their structural topology remains unaffected. By contrast, with further increasing strain, the shear stress saturates to a density-dependent plateau value, which is accompanied by pore coalescence and a gradual development of a broader pore size distribution with a discrete set of peaks at large length scales.

Molecular dynamics simulations of the mechanical annealing process in metallic glasses: Effects of strain amplitude and temperature

Molecular dynamics simulations are performed to examine the dynamic response of amorphous solids to oscillatory shear at finite temperatures. The data were collected from a poorly annealed binary glass, which was deformed periodically in the elastic regime during several hundred shear cycles. We found that the characteristic time required to reach a steady state with a minimum potential energy is longer at higher temperatures and larger strain amplitudes. With decreasing strain amplitude, the asymptotic value of the potential energy increases but it remains lower than in quiescent samples. The transient decay of the potential energy correlates well with a gradual decrease in the volume occupied by atoms with large nonaffine displacements. By contrast, the maximum amplitude of shear stress oscillations is attained relatively quickly when a large part of the system starts to deform reversibly.

The Properties of the Massive Star-forming Galaxies with an Outside-in Assembly Mode

Abstract Previous findings show that massive ( ) star-forming (SF) galaxies usually have an “inside-out” stellar mass assembly mode. In this paper, we have for the first time selected a sample of 77 massive SF galaxies with an “outside-in” assembly mode (called the “targeted sample”) from the Mapping Nearby Galaxies at the Apache Point Observatory (MaNGA) survey. For comparison, two control samples are constructed from the MaNGA sample matched in stellar mass: a sample of 154 normal SF galaxies and a sample of 62 quiescent galaxies. In contrast to normal SF galaxies, the targeted galaxies appear to be smoother and more bulge-dominated and have a smaller size and higher concentration, star formation rate, and gas-phase metallicity as a whole. However, they have a larger size and lower concentration than quiescent galaxies. Unlike the normal SF sample, the targeted sample exhibits a slightly positive gradient of the 4000 Å break and a pronounced negative gradient of Hα equivalent width. Furthermore, the median surface mass density profile is between those of the normal SF and quiescent samples, indicating that the gas accretion of quiescent galaxies is not likely to be the main approach for the outside-in assembly mode. Our results suggest that the targeted galaxies are likely in the transitional phase from normal SF galaxies to quiescent galaxies, with rapid ongoing central stellar mass assembly (or bulge growth). We discuss several possible formation mechanisms for the outside-in mass assembly mode.

Collective nonaffine displacements in amorphous materials during large-amplitude oscillatory shear.

Using molecular dynamics simulations, we study the transient response of a binary Lennard-Jones glass subjected to periodic shear deformation. The amorphous solid is modeled as a three-dimensional Kob-Andersen binary mixture at a low temperature. The cyclic loading is applied to slowly annealed, quiescent samples, which induces irreversible particle rearrangements at large strain amplitudes, leading to stress-strain hysteresis and a drift of the potential energy towards higher values. We find that the initial response to cyclic shear near the critical strain amplitude involves disconnected clusters of atoms with large nonaffine displacements. In contrast, the amplitude of shear stress oscillations decreases after a certain number of cycles, which is accompanied by the initiation and subsequent growth of a shear band.

Axial heating and temperature of RF-excited non-neutral plasmas in Penning-Malmberg traps

Electro-magnetostatic traps have been used for decades to provide long-term storage of charged particle samples or non-neutral plasmas. The dynamics and equilibrium states of these ideally simple systems can be strongly diverted from the usual working conditions (i.e. single-species, quiescent samples) in the presence of oppositely charged particles or external electric field perturbations. Both these conditions occur when the plasma is generated by means of a radio-frequency (RF) excitation continuously applied on a trap electrode. The application of RF drives of some volts over periods larger than typical collisional time scales leads to residual-gas ionization and to the accumulation of an electron plasma, a process that has previously been exploited as an alternative to thermionic or photoemission electron sources. The analysis of the axial energy distribution shows a deviation of the continuously excited final state from maxwellianity dependent on the radial position and the subsequent relaxation to equilibrium after the interruption of the drive. Systematic measurements also indicate the high sensitivity to the residual gas pressure of both the total confined charge and of the attainable densities and plasma profiles. The results are compared to the information obtained from a very simple one-dimensional electron heating model and show the validity of its most basic features together with its shortcomings.

Concordance between RNA-sequencing data and DNA microarray data in transcriptome analysis of proliferative and quiescent fibroblasts.

DNA microarrays and RNA sequencing (RNA-seq) are major technologies for performing high-throughput analysis of transcript abundance. Recently, concerns have been raised regarding the concordance of data derived from the two techniques. Using cDNA libraries derived from normal human foreskin fibroblasts, we measured changes in transcript abundance as cells transitioned from proliferative growth to quiescence using both DNA microarrays and RNA-seq. The internal reproducibility of the RNA-seq data was greater than that of the microarray data. Correlations between the RNA-seq data and the individual microarrays were low, but correlations between the RNA-seq values and the geometric mean of the microarray values were moderate. The two technologies had good agreement when considering probes with the largest (both positive and negative) fold change (FC) values. An independent technique, quantitative reverse-transcription PCR (qRT-PCR), was used to measure the FC of 76 genes between proliferative and quiescent samples, and a higher correlation was observed between the qRT-PCR data and the RNA-seq data than between the qRT-PCR data and the microarray data.

Quantitative kinetic inhibitor comparisons and memory effect measurements from hydrate formation probability distributions

In contrast with conventional experiments for ranking the performance of kinetic hydrate inhibitors (KHIs), the high pressure automated lag time apparatus (HP-ALTA) is not limited by the stochasticity of hydrate formation because it can make large numbers of formation measurements rapidly. An improved procedure for analysing HP-ALTA data is presented here in which formation probability density histograms with uniform temperature bin widths are constructed. Operations such as numerical integration and subtraction can then be applied to entire formation distributions without the need to regress the data to model analytic functions. This approach enables apparatus effects on the measured formation distributions to be quantified and mitigated. Using analogue natural gas mixtures, a demonstration of the improved method is reported here for six KHIs that were also tested using a conventional rocking cell. The cumulative formation probability distribution functions determined by numerical integration of the histograms were used to quantitatively (1) assess the performance of the KHIs, (2) study the memory effect in pure water, and (3) assess its impact on the performance of each KHI. The rankings of the KHIs obtained from the various performance metrics accessible through the HP-ALTA data were generally consistent with the rocking cell rankings, with the average absolute deviation in net subcooling for the two apparatus being 2 to 3K. In the quiescent HP-ALTA samples, the three worst performing KHIs still had expected subcoolings of about 14K unless the memory effect was present, in which case the expected net subcoolings of the three worst performing KHIs ranged from 0–6K. In contrast the memory effect reduced the expected subcoolings of the three best performing KHIs by only 1–2K. Using the new method of analysis, hydrate formation distributions measured with the HP-ALTA can also be used to identify regions of good and poor performance for a given KHI, which might aid in the determination of improved inhibition strategies or assist the development of improved hydrate inhibitors.

A Biomarker Assay For The Detection Of Contact System Activation

The contact system is composed of circulating plasma proteins that can both initiate coagulation through the intrinsic pathway and promote inflammation through the generation of bradykinin. Activation of the contact system is mediated by the assembly of factor XII (FXII), high molecular weight kininogen (HMWK), and prekallikrein (inactive form of the serine protease plasma kallikrein [pKal]) on a negatively charged surface. Bradykinin is produced from contact system activation by the proteolytic action of active pKal on its substrate HMWK. In vivo, vascular tissue injury or other unknown precipitants may expose negatively charged surfaces capable of supporting contact system activation. In vitro, the contact system is activated following exposure of plasma to substances such as kaolin, dextran sulfate, phospholipids, or surfaces such as glass. We developed a Western blot assay to detect the presence of both intact and cleaved HMWK in human and cynomolgus monkey plasma samples. Using this assay we showed that endogenous HMWK in normal human plasma was converted to cleaved kininogen following the addition of contact system activators, such as kaolin, dextran sulfate, or ellagic acid. HMWK was also shown to be cleaved by the addition of trace amounts of either FXIIa or pKal to normal human plasma. The utility of the Western blot assay was further demonstrated using plasma samples from patients with hereditary angioedema with C1 inhibitor (C1-INH) deficiency (HAE-C1-INH). HAE-C1-INH is a rare, autosomal dominant disease caused by mutations in one of the two alleles of the C1-INH gene (SERPING1). C1-INH is a serine protease inhibitor that blocks the activity of FXIIa and pKal in the contact system. HAE-C1-INH patients suffer from recurrent, localised angioedema attacks due to episodic activation of the contact system arising from unregulated pKal activity, which cleaves HMWK to release bradykinin, a potent vasoactive peptide mediating edema formation. Our results demonstrate that the method could detect significant contact system activation in HAE patient samples collected between attacks (i.e. quiescent disease samples) as compared to normal human plasma. Plasma samples collected during an HAE-C1-INH attack exhibited further elevations in cleaved kininogen. We also measured contact activation in plasma samples from cynomolgus monkeys that were dosed subcutaneously (SC) with DX-2930, a potent and specific monoclonal antibody inhibitor of plasma kallikrein being developed for HAE-C1-INH. DX-2930 blocked the cleavage of HMWK induced by kaolin-mediated contact system activation in a dose-dependent manner (5, 25, or 50 mg/Kg DX-2930, SC). In summary, this study presents a simple method that can be used both to identify disease states associated with contact system activation, and to serve as a pharmacodynamic biomarker for the development of DX-2930 as a treatment for HAE-C1-INH. Disclosures:Faucette:Dyax Corp: Employment. Cicardi:Dyax Corp: Consultancy. Kenniston:Dyax Corp: Employment. Sexton:Dyax Corp: Employment. Adelman:Dyax Corp: Employment.

DO QUIESCENT AND ACTIVE GALAXIES HAVE DIFFERENTMBH-σ*RELATIONS?

To investigate the validity of the assumption that quiescent galaxies and active galaxies follow the same black hole mass - stellar velocity dispersion relation, as required for the calibration of M_BH estimators for broad line AGNs, we determine and compare the M-sigma relations, respectively, for quiescent and active galaxies. For the quiescent galaxy sample, composed of 72 dynamical M_BH measurements, we update sigma for 28 galaxies using homogeneous H-band measurements that are corrected for galaxy rotation. For active galaxies, we collect 25 reverberation-mapped AGNs and improve sigma measurement for two objects . Combining the two samples, we determine the virial factor $f$, first by scaling the active galaxy sample to the M-sigma relation of quiescent galaxies, and second by simultaneously fitting the quiescent and active galaxy samples, as f=5.1_{-1.1}^{+1.5} and f=5.9_{-1.5}^{+2.1}, respectively. The M-sigma relation of active galaxies appears to be shallower than that of quiescent galaxies. However, the discrepancy is caused by a difference in the accessible M_BH distribution at given sigma, primarily due to the difficulty of measuring reliable stellar velocity dispersion for the host galaxies of luminous AGNs. Accounting for the selection effects, we find that active and quiescent galaxies are consistent with following intrinsically the same M-sigma relation.