Robust validation of predictive turbulent transport models requires quantitative comparisons to experimental measurements at multiple levels, over a range of physically relevant conditions. Toward this end, a series of carefully designed validation experiments has been performed on the DIII-D tokamak [J. L. Luxon, Nucl. Fusion 42, 614 (2002)] to obtain comprehensive multifield, multipoint, multiwavenumber fluctuation measurements and their scalings with key dimensionless parameters. The results of two representative validation studies are presented: an elongation scaling study performed in beam heated L-mode discharges and an electron heating power scan performed in quiescent H-mode (QH-mode) discharges. A 50% increase in the elongation κ is observed to lead to a ∼50% increase in energy confinement time τe and accompanying decrease in fluctuation levels, qualitatively consistent with a priori theoretical predictions and nonlinear GYRO [J. Candy and R. E. Waltz, J. Comput. Phys. 186, 545 (2003)] simulations. However, these simulations exhibit clear quantitative differences from experiment in the predicted magnitudes and trends with radius of turbulent fluxes and fluctuation levels which cannot be fully accounted for by uncertainties due to transport stiffness. In the QH-mode study, local nonlinear GYRO simulations that neglect fast ion effects show a similar proportional response to the applied electron cyclotron heating as the experiment, but overpredict the magnitudes of transport and fluctuation levels by a factor of 10 or more. Possible sources of this overprediction, namely nonlocal effects and self-consistent fast beam ions, are identified and discussed.