INTRODUCTION: The prevalence of obesity has currently risen to 42% of adults in the United States (US). Obesity continues to be an epidemic, and the commercial industry has significantly increased the number of weight loss advertisements to capitalize on this fact. Americans have spent upward of $35 billion on products for weight loss, which brings us to this case. CASE DESCRIPTION/METHODS: 36-year-old female presented to the hospital for epigastric/right upper quadrant abdominal pain of five days. Characterized as constant, non-radiating and worse at night. Associated with fevers, chills, nausea, vomiting, anorexia, eight-pound weight loss and jaundice. Patient took two tablets of acetaminophen without relief. Liver function tests (LFTs) on admission showed AST 329, ALT 407, Alkaline Phosphatase 415, Albumin 3.1, T bilirubin 5.5, and direct bilirubin 3.8. Abdominal imaging was negative Her LFTs continued to trend up, and on further questioning patient admitted to taking diet pills from Mexico, called Acxion and Norex, approximately 1-month ago for 10 days. Patient underwent a liver biopsy, which eventually showed acute liver injury that is toxin mediated. Infectious and autoimmune workup was negative. DISCUSSION: According to literature search, Acxion and Norex have not been previously implicated in acute liver injury. These medications are routinely sold in Mexico for weight loss. As McAllen, Texas is a bordering town to Mexico, it is common practice for patients to go to Mexico to get procedures done or take medications for weight loss. These patients are easily preyed upon, and it is imperative that we educate our community as this can lead to serious health consequences if people continue to go to Mexico and use these medications. The time to onset of liver injury can range between 5 days to 3 months of starting a medication [1]. This can be further complicated when patients take multiple medications that can result in harmful drug interactions. The safest way to lose weight is calorie restriction and increased physical activity; unfortunately, there are no quick fixes.Figure 1.: Zonal necrosis with bridging, most consistent with acute liver injury, toxin/medication related.Figure 2.: Zonal necrosis with bridging, most consistent with acute liver injury, toxin/medication related.Figure 3.: Zonal necrosis with bridging, most consistent with acute liver injury, toxin/medication related.