Quick Absorption Research Articles

Development of Vitamin C-Enriched Oral Disintegration Films Using Chia Mucilage

Oral disintegration films (ODFs) offer a convenient alternative for administering active compounds with quick absorption, no need for water, customizable formulation, and promising pharmaceutical applications. This study aimed to develop chia mucilage films as a new polymer to carry vitamin C. Chia mucilage was extracted using the method of immersing the seeds in water, separated by vacuum filtration and using a sieve to remove the mucilaginous gel, then centrifuged and finally freeze-dried, with the mucilage obtained being used to produce films using the casting technique. The formulations included a control and a 1% vitamin C variant, with glycerol as a plasticizer. The produced films showed high solubility, pH close to the oral and a disintegration time of 53.17 s for the formulation with 1% vitamin C. The presence of vitamin C in the polymer matrix, as well as the interactions between them, were confirmed by DSC and FTIR spectra. On the first day of storage, after 1 min of reaction at 30 °C, the vitamin C concentration obtained was 477.50 mg/g, while at 40 °C was 411.28 mg/g. After 35 days of storage, the films showed a reduction in vitamin C concentration. Chia mucilage proved to be a promising polymer in the production of ODFs carrying vitamin C.

Foliar Application of Urea and Amino Acids Regulates Growth, Photosynthesis, Pigments, Antioxidant Activity, and the Essential Oil Content and Composition of Basil (Ocimum basilicum L.)

Basil (Ocimum basilicum L.) is a prominent medicinal and aromatic plant, widely recognized for its bioactive compounds and substantial economic value across the pharmaceutical, culinary, and industrial sectors. In light of increasing global demand and environmental challenges, this study explores novel approaches to enhance its sustainable production and improve its quality. Urea is the most common form of nitrogen (N) for foliar application due to its quick absorption, affordability, high solubility, as well as relatively low cost per N unit. Amino acids are an organic form of N and play a role in plant protein structure, stress tolerance, and the biosynthesis of secondary metabolites. This research aimed to evaluate the effects of urea (0, 1, and 2 g L−1) and an amino acid-based biostimulant (AAB) (0, 4, and 8 mg L−1), applied foliarly, on the growth, photosynthesis, pigments, antioxidant activity, and essential oil production of basil (Ocimum basilicum L.). The best results in terms of leaf number, area, and fresh and dry weight were observed with the combination of 2 g L−1 urea and 8 mg L−1 AAB. The growth enhancement due to this treatment may be attributed to stimulatory effects on photosynthesis and N content. Chlorophyll, carotenoids, anthocyanins, photosynthesis, stomatal conductance, total phenols, and total flavonoids increased with urea application up to 1 g L−1. Additionally, AAB application up to 8 mg L−1 increased total chlorophyll, carotenoid, total phenols, and total flavonoids, while photosynthesis and anthocyanin content increased with 4 mg L−1 AAB. Although urea did not significantly affect essential oil content and yield, AAB application increased both. Finally, the combination of 1 g L−1 urea and 8 mg L−1 AAB had the most effective impact on improving content and yield of essential oil, total phenol, flavonoid, anthocyanin, and antioxidant activity, with a relatively high percentage of estragole.

Advantages of Nasal Drug Delivery System

The nasal drug delivery system has received a lot of interest as a non-invasive and effective way to provide medications. Its distinct benefits include quick absorption due to the nasal mucosa's extensive vascularization, bypassing first-pass metabolism, and increased bioavailability when compared to oral administration. This approach is especially useful for administering medications that have little gastrointestinal stability or are destroyed by hepatic enzymes. The nasal route offers an alternative to systemic medication administration, particularly for individuals who have difficulties swallowing pills or injections. Furthermore, the nasal cavity's closeness to the brain makes it an appealing alternative for treating central nervous system problems, as medications can traverse the blood-brain barrier via the olfactory and trigeminal pathways. Nasal administration is also simple, patient-friendly, and inexpensive, with minimum pain. Advances in formulation technology, such as nanoparticles and mucoadhesive compounds, have improved medication retention and effectiveness. Despite its potential, issues including mucosal irritation and low medication volume must be addressed. Overall, the nasal medication delivery system is a potential tool for increasing treatment results and patient compliance.

Detailing the redox ability of supported Pt-Sn and Pt-In catalysts for CO2-assisted PDH

Alloying Pt with In or Sn crucially improves Pt-based propane dehydrogenation (PDH) catalysts. CO2-assisted PDH (CO2-PDH) offers further benefits through H2 and carbon oxidation, but adds a complex interplay between alloy oxidation, nanoparticle (NP) sintering and carbon formation. Developing Pt-based CO2-PDH catalysts requires deconvoluting the hereto unidentified alloy properties and reaction mechanisms. This is studied through in situ Quick X-ray Absorption Spectroscopy and Temporal Analysis of Products on Pt:Sn/MgAl2O4 (Pt:Sn) and Pt:In/MgAl2O4 (Pt:In) catalysts (3 wt% Pt and 3 wt% In/Sn). Pure CO2 segregates the alloys while cofeeding CO2 and H2 largely retains Pt3Sn and Pt13In9 phases. On Pt:Sn, CO2 mainly interacts with H2 and carbon deposits via a Langmuir-Hinshelwood mechanism. Regenerative H2/O2 cycles cause Sn enrichment with a constant 0.9 nm NP size. Pt:In retained the Pt13In9 phase but showed NP growth from 0.8 to 2.1 nm, with greater susceptibility to alloy segregation and vaporization of In. This highlights Pt:Sn as more promising catalyst.

Analysis of Herbal Constituents and InVivo Pharmacokinetics of Gegen-Huangqi Decoction in Rat Plasma Using HPLC-Q-TOF-MS/MS and HPLC-QQQ-MS/MS.

The traditional Chinese medicine (TCM) formula, gegen-huangqi (GH) decoction, has been employed for over 200 years, notably for its therapeutic effects in treating conditions such as atherosclerosis and diabetes mellitus. Despite its long-standing use, comprehensive studies on the chemical constituents of GH and their invivo pharmacokinetics (PK) remain limited. This study aimed to profile the bioactive compounds present in GH decoction and to explore their PK characteristics using HPLC-Q-TOF-MS/MS. Furthermore, a robust and validated analytical method was developed and applied to assess the PK of 11 plasma compounds using HPLC-QQQ-MS/MS. In total, 79 components were identified within the GH decoction. Pharmacokinetic analysis revealed distinct absorption and elimination profiles for compounds such as puerarin, daidzin, genistin, calycosin-7-O-β-D-glucoside, and ononin, which exhibited profiles of quick absorption and excretion. Conversely, compounds such as daidzein, formononetin, genistein, astragaloside II, astragaloside IV, and calycosin showed more complex invivo metabolic patterns, leading to multipeak concentration-time curves. All compounds, except astragalosides II and IV, were found to undergo significant hepatic clearance. These findings provide valuable insights into the pharmacokinetic behavior of GH decoction, which lays the foundation for further quality control, pharmacological exploration, and potential clinical application of this traditional remedy.

Patient and Parent/Caregiver Satisfaction with Efficacy and Cosmetic Elegance of Tapinarof Cream 1% Once Daily in a Long-term Extension Trial in Adults and Children Down to Age 2 Years with Atopic Dermatitis

Introduction: Patients with atopic dermatitis (AD) report low satisfaction with currently available topical therapies. Satisfaction and patient preference are closely linked to treatment adherence, and understanding preferences may contribute to improving the quality of AD care and adherence. In the pivotal 8-week, phase 3 ADORING 1 and 2 trials, tapinarof cream 1% (VTAMA®, Dermavant Sciences, Inc.) once daily (QD) demonstrated superior efficacy versus vehicle and was well tolerated in adults and children down to age 2 years with AD. We report Patient Satisfaction Questionnaire© (PSQ) results from ADORING 3, a 48-week, open-label extension trial. Methods: In ADORING 3, eligible patients from ADORING 1 and 2, from a 4-week maximal usage pharmacokinetics trial, and tapinarof-naive patients with mild AD, or moderate or severe AD, that did not meet inclusion criteria for ADORING 1 or 2, were followed for up to 48 weeks. The PSQ was completed at Week 48 or at early termination visit and assessed patient or parent/caregiver satisfaction with tapinarof efficacy, cosmetic elegance (look and feel of tapinarof cream), application ease, impact on daily life, and preference for tapinarof versus prior AD therapies. Patients aged ≥16 years self-completed the PSQ; parents/caregivers completed for children aged 2 to 15 years. Results: 505 patients or parents/caregivers completed the questionnaire. Respondents consistently reported high rates of satisfaction across all parameters. Most patients or parents/caregivers strongly agreed or agreed with PSQ questions assessing satisfaction with cosmetic elegance (91.5%), quick absorption (89.5%), application ease (97.6%), impact on daily life (94.3%), efficacy (92.3%), and confidence in tapinarof (92.7%). For patients or parents/caregivers who reported prior use of other topical therapies to treat AD, most strongly agreed or agreed that tapinarof was more effective (86.3%), easier to use (68.6%), and that they preferred tapinarof to prior topicals (88.0%). Compared with systemic drugs used previously for AD, most strongly agreed or agreed that tapinarof was more effective (84.6%), easier to use (77.6%), and that they preferred tapinarof to prior systemic drugs (85.9%). Conclusion: Patient or parent/caregiver satisfaction data from ADORING 3 showed a consistent and highly positive perception of long-term use of tapinarof cream across all parameters, including satisfaction with tapinarof efficacy, cosmetic elegance, application ease, impact on daily life, and preference for tapinarof compared with prior AD therapies. Satisfaction with tapinarof is likely to contribute to long-term adherence and improved outcomes for patients with AD.

(Invited) Evolution of Single Atom Catalysts during CO2 Electrocatalytic Reduction

The re-utilization of CO2 via its electrocatalytic reduction (CO2RR) into value-added chemicals and fuels is a promising avenue to minimize the impact of existing technologies on the climate change. This requires the development of low cost, efficient, selective and durable electrocatalysts based of their rational understanding. Moreover, it should be considered that even morphologically and chemically well-defined pre-catalysts can be susceptible to drastic modifications under operation, especially when the reaction conditions themselves change dynamically.This talk will address the transformations that Metal-N-C catalysts (M=Cu, Ni, Co, Fe, Sn, Zn) experience during static and pulsed CO2RR using operando quick X-ray absorption spectroscopy (XAS) and Raman spectroscopy. In particular, I will illustrate the astonishing behaviordisplayed by Cu-N-C catalystsduring CO2RR, featuring reversible transformations from single atom sites towards Cu nanoparticles. The switchable nature of these species that can be achieved by applying different potential pulses holds the key for the on-demand control of the distribution of the CO2RR products and thus, a wide-spread adoption of this process.Moreover, I will elucidate the nature of the ligands forming under CO2RR at singly dispersed Ni sites in Ni-N-C catalysts, which are currently drawing great attention for their high performances in the CO formation. This will be achieved by a synergistic combination of conventional XAS, high energy resolution fluorescence detected X-ray absorption near edge structure (HERFD-XANES) spectroscopy, and X-ray emission spectroscopy (XES) coupled with unsupervised and supervised machine learning methodologies and density functional theory.Overall, my lecture will feature the importance of operando characterization of electrocatalysts in order to unveil structure/composition-reactivity correlations during CO2RR.

An Unravelled Potential of Foliar Application of Micro and Beneficial Nutrients in Cereals for Ensuring Food and Nutritional Security

Micronutrient deficiency in soil and crops is a critical issue that contributes to what is known as hidden hunger. Hidden hunger refers to the lack of essential vitamins and minerals in people diets, often due to the poor nutrient content of staple crops, which can lead to significant health problems despite adequate caloric intake. Micronutrients are required in small amounts but are crucial for various physiological functions in plants, including cereals for enzyme activation, photosynthesis, nitrogen fixation, and synthesis of vital compounds. Corrective measures to address micronutrient deficiencies include soil application, seed treatment, foliar sprays, and genetic biofortification. Foliar sprays are particularly effective as they allow for the direct application of nutrients to plant leaves, ensuring quick absorption and utilization. This method can rapidly correct deficiencies, improve crop yields, and enhance the nutritional quality of the produce. Previous research has shown the efficacy of foliar sprays in addressing micronutrient deficiencies. Additionally, advancements in nanotechnology have led to the development of more efficient foliar spray formulations that enhance nutrient uptake and minimize environmental impact. Overall, addressing micronutrient deficiencies through foliar sprays and other agronomic practices is vital for improving crop health, yield, and nutritional quality, thereby contributing to food security and the alleviation of hidden hunger. However, specific dose of each micro- and beneficial nutrients are highly related to crops and cropping systems, season, agroclimatic conditions, materials used, and crop growth stage. The review article focuses on all issues and concerns with possible options for correcting micronutrient deficiency in cereals to ensure food and nutritional security and agricultural sustainability.

Reversible metal cluster formation on Nitrogen-doped carbon controlling electrocatalyst particle size with subnanometer accuracy

Copper and nitrogen co-doped carbon catalysts exhibit a remarkable behavior during the electrocatalytic CO2 reduction (CO2RR), namely, the formation of metal nanoparticles from Cu single atoms, and their subsequent reversible redispersion. Here we show that the switchable nature of these species holds the key for the on-demand control over the distribution of CO2RR products, a lack of which has thus far hindered the wide-spread practical adoption of CO2RR. By intermitting pulses of a working cathodic potential with pulses of anodic potential, we were able to achieve a controlled fragmentation of the Cu particles and partial regeneration of single atom sites. By tuning the pulse durations, and by tracking the catalyst’s evolution using operando quick X-ray absorption spectroscopy, the speciation of the catalyst can be steered toward single atom sites, ultrasmall metal clusters or large metal nanoparticles, each exhibiting unique CO2RR functionalities.

Operando X-ray Absorption Spectroscopy as a Powerful Tool for Uncovering Property-Activity Relationships for Oxygen Evolution Transition Metal Oxide Catalysts.

The development of a sustainable and environmentally friendly energy economy encompasses efficient hydrogen production from renewable energy via electrolysis. In this context, great efforts have recently been dedicated to the development of more efficient and cost-effective electrocatalysts. Understanding the mechanism of the oxygen evolution reaction (OER) on transition metal oxide catalysts is of great interest, but the reaction and system complexity render the characterization of active sites and the understanding of reaction mechanisms challenging. Time resolved Quick X-ray Absorption Spectroscopy (XAS) can provide dynamic snapshots of the electronic and local structure of nanocatalysts, revealing the 'real active phase' of the catalyst, which can substantially differ from the as-prepared catalyst powder or the catalyst in form of an electrode under non-operating conditions. In this contribution, several examples will be presented showing how operando XAS can reveal catalyst-support interactions, changes in the reaction mechanism, and dynamic reversible/irreversible changes in the electronic and local structure of OER catalysts.

RAPID DISSOLUTION: DEVELOPMENT AND ASSESSMENT OF A NOVEL DRUG FORMULATION

This study focuses on the development and assessment of a novel fast-dissolving drug formulation aimed at improving drug delivery efficiency and patient compliance. The formulation was designed to dissolve rapidly in the oral cavity, facilitating quick absorption and onset of action. Through a systematic approach, the formulation's composition, including excipients and active pharmaceutical ingredients, was optimized to achieve rapid dissolution while maintaining stability and bioavailability. Various techniques, such as direct compression, freeze-drying, and spray drying, were explored to produce the fast-dissolving drug formulation. Evaluation of the formulation involved assessments of dissolution kinetics, drug release profile, physical characteristics, and pharmacokinetic parameters. The results demonstrate the potential of the fast-dissolving drug formulation to offer enhanced drug delivery and improved patient experience, making it a promising option for pharmaceutical development.

Validation of spectrophotometric and colorimetric methods for determination of efavirenz in various biological matrices: Application to the development of dissolvable microneedle-based efavirenz complex inclusion for vaginal delivery

One of the antiretroviral treatments (ART) used to treat Human Immunodeficiency Virus (HIV) disease is efavirenz (EFV). EFV itself has bioavailability issues during oral therapy due to its poor solubility. When injected, administration issues arise. Hence, creating medication delivery methods was crucial to creating EFV delivery. HIV therapy benefits from the vaginal medication delivery system's ease of use, higher bioavailability, and quick systemic absorption in the surface folds. In this study, an inclusion complex (IC) was added to the EFV formulation to increase solubility, and dissolving microneedles (DMN) was used for delivery to increase penetration. Here, in support of this formulation creation process, we carried out validation utilizing spectrophotometric and colorimetric techniques. The amount of EFV was determined by validating ethanol and artificial vaginal fluid (AVF) using UV–Vis spectrophotometry. Vaginal tissue and plasma were also validated using colorimetric with the β-naphthol reagent. The International Council for Harmonization (ICH) and US Food and Drug Administration (FDA) requirements were adhered to in verifying the creation of analytical procedures. The outcomes demonstrated a linear correlation value of ≥0.9998. The LLOQ levels were 0.99 g/mL, 0.97 g/mL, 0.66 g/mL, 0.74 g/mL, and 0.74 g/mL in ethanol, AVF, porcine vaginal tissue, rat vaginal tissue, and vaginal plasma, respectively. The developed precision and accuracy were confirmed. The approach was successfully used to determine the amount of EFV in inclusion complex integration and DMN platform. The outcomes demonstrated high IC-EFV incorporation release and penetration profiles, permeation and high drug retention andex vivokinetics in the vagina and enhanced bioavailability fromin vivostudy pharmacokinetic profiles of DMN-IC-EFV.

Tapinarof Cream 1% Once Daily Improves Patient-Reported Outcomes in the Treatment of Mild to Severe Plaque Psoriasis in the Head and Neck Region

Introduction: Tapinarof cream 1% (VTAMA®, Dermavant Sciences, Inc.) is a non-steroidal, topical aryl hydrocarbon receptor agonist approved for the treatment of plaque psoriasis in adults with no restrictions on location, extent, or duration of use. In the phase 3 PSOARING trial program, tapinarof cream 1% once daily (QD) for the treatment of plaque psoriasis was efficacious and well tolerated. Plaque psoriasis affecting the head and neck region occurs commonly, with a high impact on patients’ health-related quality of life, through pruritus and psychological distress. Patients may consider topicals unacceptable for scalp/facial use due to poor cosmetic properties (e.g., greasiness), leading to low medication adherence. There is a need for efficacious, cosmetically elegant, non-steroidal topicals that can be used without restrictions.Objective: To assess patient-reported outcomes (PROs) with tapinarof cream for adults with mild to severe plaque psoriasis in the head and neck region, including the scalp, in a phase 4, open-label trial.Methods: Adults with head and neck region target lesion Physician Global Assessment (tPGA) score of 2 (mild), 3 (moderate), or 4 (severe) received tapinarof for 12 weeks. PROs included Peak Pruritus Numerical Rating Scale (PP-NRS) score for the head and neck region; achievement of ≥4-point reduction in PP-NRS score; Dermatology Life Quality Index (DLQI) score by visit; and responses to a Patient Satisfaction Questionnaire© (PSQ) at Week 12.Results: 31 patients received tapinarof; 58.1% (18/31) had the target lesion on the scalp. Baseline mean PP-NRS (head and neck region) and total DLQI scores were 5.8 and 9.7, respectively, demonstrating significant pruritus and disease impact. Improvement in mean PP-NRS score was demonstrated at Week 1 (–1.6), the earliest assessment, surpassing the minimal clinically important ≥4-point improvement by Week 12 (−4.2). At Week 12, 70.0% (n=14/20) achieved ≥4-point reduction in PP-NRS score. Mean DLQI minimal clinically important difference of −4.0 was demonstrated as early as Week 1 (−4.0), improving to −7.2 at Week 12. Most patients strongly agreed or agreed with PSQ questions assessing satisfaction with cosmetic elegance (93.3%), quick absorption (96.7%), application ease (86.7%), efficacy (83.3%), and confidence in tapinarof (83.3%). Compared with topicals used previously for plaque psoriasis, most strongly agreed or agreed that tapinarof was more effective (76.9%) and easier to use (76.9%).Conclusions: In patients with plaque psoriasis affecting the head and neck region, tapinarof cream 1% QD demonstrated rapid and clinically meaningful improvements in patient-reported pruritus and disease impact as early as Week 1, the first assessment, with continued improvement through Week 12. Patients reported high rates of satisfaction and positive perceptions of tapinarof.Funding Support: Dermavant Sciences, Inc.

Temperature-Tunable Operando Nondestructive Detection of Electronic and Geometrical Structures in Battery Electrodes.

Real-time monitoring of the structural evolution of battery materials is crucial for understanding their underlying reaction mechanisms, which cannot be satisfied by the typically used post-mortem analysis. While more and more operando techniques were constructed and employed, they are all based on ambient working conditions that are not generally the case for real-world applications. Indeed, batteries work in an environment where self-heat dissipation increases the surrounding temperature, and extreme temperature applications (<-20 °C or >60 °C) are also frequently proposed. Operando characterization techniques under variable temperatures are therefore highly desired for tracking battery reactions under real-working conditions. Here, we develop a methodology to operando monitor the electronic and geometrical structures of battery materials over a wide range of temperatures based on X-ray spectroscopies. It is substantiated with data collected on a model LiNi0.90Co0.05Mn0.05O2/Si@C pouch cell under operando quick X-ray absorption fine structure spectroscopy, by which we found a temperature-dependent structure evolution behavior that is highly correlated with the electrochemical performance. Our work establishes an exemplary protocol for analyzing battery materials under temperature-variable environments that can be widely used in other related fields.

Nose-to-brain delivery of microcarrier in the treatment of neurodegenerative diseases

Neurodegenerative diseases (NDs) have emerged as a major global health concern due to the perpetually aging population and unhealthy lifestyle. The most prevalent NDs, such as Alzheimer’s, Parkinson’s, and Migraine, have seen a great deal of research into dependable and efficient treatment approaches. However, the conventional approach to treating NDs is not very effective due to the presence of the blood–brain barrier (BBB). BBB is a major hurdle for the delivery of various therapeutic agents to the brain. Nasal drug delivery is a novel approach providing direct delivery of drugs to the brain through the olfactory and trigeminal neurons. The nasal route also guarantees quick absorption, avoiding first-pass metabolism and early action of therapeutic activity. The nasal cavity has excellent permeability and effective absorption, of drugs including peptides, proteins, and tiny molecular weight polar medicines, which are difficult to administer by anything other than injection or where a fast onset of action is necessary. Microspheres (MSs) are micron-sized particles that can be used in nose-to-brain delivery. The main justification for using MSs for nose-to-brain delivery is to increase the likelihood that the medication will be absorbed by enabling closer and longer contact between the medication and the mucosal barrier. MSs swell on contact with nasal mucosa and solidify into a gel to prevent its clearance from the nasal cavity. This article made a comprehensive review of the application of MS in nose-to-brain drug delivery as a unique approach to treating NDs.

Pharmacological profiling of a berbamine derivative for lymphoma treatment

AbstractCa2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) has been identified as a potential target for treating cancer. Based on our previous study of berbamine (BBM) as a CAMKIIγ inhibitor, we have synthesized a new BBM derivative termed PA4. Compared with BBM, PA4 showed improved potency and specificity and was more cytotoxic against lymphoma and leukemia than against other types of cancer. In addition to indirectly targeting c-Myc protein stability, we demonstrated that its cytotoxic effects were also mediated via increased reactive oxygen species production in lymphoma cells. PA4 significantly impeded tumor growth in vivo in a xenograft T-cell lymphoma mouse model. Pharmacokinetics studies demonstrated quick absorption into plasma after oral administration, with a maximum concentration of 1680 ± 479 ng/mL at 5.33 ± 2.31 hours. The calculated oral absolute bioavailability was 34.1%. Toxicity assessment of PA4 showed that the therapeutic window used in our experiments was safe for future development. Given its efficacy, safety, and favorable pharmacokinetic profile, PA4 is a potential lead candidate for treating lymphoma.

Formulation and evaluation of a face serum containing fenugreek extract

Background: Wrinkles on the face and aging of the skin are an undesirable effect of photodamage and ultraviolet radiation. Serum has a quick absorption and ability to penetrate deep layers of the skin, as well as a non-oily finish and a deep formula with a very high amount of active ingredients. Methods: In this study, we have formulated and evaluated a face serum containing combination of aqueous extract of fenugreek seed and lemon oil. Results: Facial serum was tested for its pH, physical appearance, viscosity, microbial testing, cyclic temperature test, etc. The results of the stability study show that there was no change in visual acuity, homogeneity. Conclusions: Serum containing Fenugreek extract have been able to cure bacterial infections and inflammations of facial skin, and other signs also moistens the skin without any side effects making skin soft, smooth and supple.

Insights into Recent Updates on Factors and Technologies That Modulate the Glycemic Index of Rice and Its Products.

Rice is a staple food and energy source for half the world's population. Due to its quick digestion and absorption in the gastrointestinal tract, rice is typically regarded as having a high or medium-high glycemic index (GI); however, this can vary depending on the variety, nutrient compositions, processing, and accompanying factors. This report included a table of the glycemic index for rice and rice products in different countries, which could give an overview and fundamental information on the recent GI of different rice varieties. In addition, latest updates about the mechanism effects of rice nutritional profiles and processing techniques on GI were also provided and discussed. The influence of state-of-the-art GI regulation methods was also evaluated. Furthermore, the effectiveness and efficiency of applied technologies were also given. Furthermore, this review offered some aspects about the potential nutraceutical application of rice that food scientists, producers, or consumers might consider. Diverse types of rice are grown under various conditions that could affect the GI of the product. The instinct nutrients in rice could show different effects on the digestion rate of its product. It also revealed that the rice product's digestibility is process-dependent. The postprandial glucose response of the rice products could be changed by modifying processing techniques, which might produce the new less-digestive compound or the inhibition factor in the starch hydrolysis process. Because of the significant importance of rice, this paper also concluded the challenges, as well as some important aspects for future research.

Effectiveness of Intranasal Analgesia in the Emergency Department.

In the Emergency Department (ED), pain is one of the symptoms that are most frequently reported, making it one of the most significant issues for the emergency physician, but it is frequently under-treated. Intravenous (IV), oral (PO), and intramuscular (IM) delivery are the standard methods for administering acute pain relief. Firstly, we compared the safety and efficacy of IN analgesia to other conventional routes of analgesia to assess if IN analgesia may be an alternative for the management of acute pain in ED. Secondly, we analyzed the incidence and severity of adverse events (AEs) and rescue analgesia required. We performed a narrative review-based keywords in Pubmed/Medline, Scopus, EMBASE, the Cochrane Library, and Controlled Trials Register, finding only twenty randomized Clinical trials eligible in the timeline 1992-2022. A total of 2098 patients were analyzed and compared to intravenous analgesia, showing no statistical difference in adverse effects. In addition, intranasal analgesia also has a rapid onset and quick absorption. Fentanyl and ketamine are two intranasal drugs that appear promising and may be taken simply and safely while providing effective pain relief. Intravenous is simple to administer, non-invasive, rapid onset, and quick absorption; it might be a viable choice in a variety of situations to reduce patient suffering or delays in pain management.

Review–Formulation Development of Semi-Solid Dosage Form

Semi-solid dosage forms are generally found in medicines for all types of patients. Though, they have specific advantages, along with fast efficacy due to the devoid of dissolution time and quick absorption in the skin surface. Semi-solid formulations have been broadly used in pharmacy due to their high dosing adjustability, easy use off, and rapid onset of action. Keywords: Semi-solid dosage forms, Gels, Ointment, Cream