In-situ shattered rocks are often associated with seismogenic fault zones, but their mechanism of formation is still matter of debate, partly because of the limited number of field studies. Here we describe the characteristics of in-situ shattered rocks distribution along the NW-SE-striking seismogenic Monte Marine Fault (MMF) in the Italian Central Apennines. In the studied area, the MMF cuts through Mesozoic carbonates, is exhumed from <3 km depth and consists of two >5 km-long major hard-linked segments with normal kinematics. The linkage between the two fault segments occurs along a ∼2 km-long step-over zone with E-W trending faults and oblique-slip kinematics. To the northwest, fault-related shear deformation is localized in a ∼5 m-thick cataclastic fault core and off-fault deformation is dominated by in-situ shattered rocks up to ∼40 m-thick. Instead, in the step-over zone to the southeast, the in-situ shattered rocks are up to ∼500 m thick, particularly where MMF crosscuts older low-angle thrust faults.We integrated detailed field structural surveys with microstructural and grain size distribution analyses of the fault rocks to assess the mechanism of (1) formation of in-situ shattered rocks and, (2) progressive localization of shear deformation along the MMF. The obtained results, after the viability of several formation mechanisms (mechanical models) have been reviewed, support the hypothesis that the formation of in-situ shattered rocks was associated with the propagation of (multiple) seismic ruptures (mainshocks and aftershock sequences) within a mechanically heterogeneous fault zone. Heterogeneity is due to the occurrence of preexisting damage related to previous earthquakes, but also inherited from the older low-angle thrust faults. Therefore, we suggest that the origin of these shattered rocks is more compatible with seismic related processes than only with quasi-static fault growth models. On the other hand, the cataclastic fault core derived from the progressive accommodation of shear deformation within the in-situ shattered rock volumes during several seismic cycles. We conclude that the large volumes of in-situ shattered rocks are the result of seismic-related dissipative processes in a geometrically and mechanically heterogeneous fault zone. In this scenario, large volumes of in-situ shattered rocks are compliant low velocity zones which can influence the propagation of earthquake ruptures.