Diverse late Neoarchean granitoids are widely exposed in the Western Shandong province (WSP). According to geological relationships, lithological features, magmatic zircon U–Pb–Lu–Hf isotopes and whole-rock chemical characteristics, eight main lithological assemblages are identified, and their petrogenesis is determined. (1) The ~2.54 Ga and ~2.51 Ga potassic granites show the highest SiO2 contents (67.06–75.84 wt%) and were sourced from partial melting of metamorphic greywackes. (2) The ~2.53 Ga quartz syenites exhibit the highest alkali contents (10.32–11.23 wt%) and were sourced from mantle-derived basaltic rocks and recycled sediments. (3) The ~2.53–2.52 Ga quartz diorites (less-differentiated sanukitoids) formed from partial melting of metasomatized mantle. (4) The ~2.53 Ga hornblendites have crystallization ages and Lu–Hf isotopes similar to those of the quartz diorites, implying that they are cogenetic cumulates from the quartz dioritic magmas. (5) The ~2.56–2.52 Ga tonalite-trondhjemite-granodiorite (TTG) gneisses were formed by melting of thickened crust. (6) The ~2.53 Ga high-Mg granodiorites (differentiated sanukitoids) were formed by mixing of crust-mantle melts. (7) The ~2.51–2.49 Ga gabbros originated from partial melting of fluid-metasomatized mantle. (8) The ~2.54–2.53 Ga high-Mg andesites (boninites) originated from partial melting of refractory mantle that experienced the extraction of basaltic magma at earlier stage and was then enriched in LILEs and LREEs by slab-derived melts.Integrating the petrogenesis of these late Neoarchean diversified granitoids and associated volcanic rocks, we consider that the late Neoarchean was a crucial period of crust-mantle interaction in the WSP, and partial melting of the metasomatized mantle produced intermediate-mafic melts, then underplating of the mantle-derived magmas caused the partial melting of crustal materials, further led to the mixing of crust-mantle magmas. The above complex crust-mantle interactions triggered the transfer of energy and materials from the Earth’s interior to the surface, forming modern-like continental crust thickness and geothermal gradient. Moreover, combining late Neoarchean intense granitic magmatism and ~2.49 Ga mafic dike swarms implies that the North China Craton experienced cratonization processes at the end of the Neoarchean.