Quartile Of Magnesium Intake Research Articles

Association of dietary magnesium intake with chronic constipation among US adults: Evidence from the National Health and Nutrition Examination Survey.

The association of dietary magnesium intake with chronic constipation has not been well‐studied in general population. Therefore, the aim of this study was to examine whether increased intake of dietary magnesium is associated with the presence of chronic constipation. Data from the 2007–2010 National Health and Nutrition Examination Survey (NHANES) were used. A total of 9,519 participants (4,814 men and 4,705 women) aged ≥20 years were included. The individual's bowel habits (chronic constipation) were evaluated using the questionnaire on bowel health and two different definitions of constipation (stool consistency and stool frequency) were used. Dietary magnesium intake was obtained from 24‐h dietary recall. Participants were categorized based on the quartiles of magnesium intake. Multivariable logistic regressions models were performed controlling for confounding factors. After multivariable adjustment, dietary magnesium intake was inversely associated with chronic constipation defined by stool frequency, and the ORs (95% CIs) across quartiles 2–4 compared with the lowest quartile were 0.71 (0.51–0.99), 0.78 (0.46–1.31), and 0.39 (0.16–0.95), respectively. In addition, there was a significant trend for the decreased prevalence of chronic constipation by quartiles of magnesium intake only among men (p for trend < .001). However, no statistically significant association between magnesium intake and prevalence of chronic constipation defined by stool consistency was observed. More evidence from longitudinal studies is needed to confirm these findings.

Relation of Magnesium Intake With Cardiac Function and Heart Failure Hospitalizations in Black Adults: The Jackson Heart Study.

Little is known about magnesium intake and risk of heart failure (HF) hospitalizations, particularly in blacks. We hypothesize that magnesium intake relates to HF hospitalization in blacks. From the Jackson Heart Study cohort (n=5301), we studied 4916 blacks recruited during 2000 to 2004 in Jackson (Mississippi), who completed an 158-item Food-Frequency Questionnaire that included dietary supplements. Daily magnesium intake derived from the questionnaire was divided by the body weight to account for body storage and stratified by quartiles (0.522-2.308, 2.309-3.147, 3.148-4.226, and ≥4.227 mg magnesium intake/kg). Cox proportional hazards modeling assessed the association between quartiles of magnesium intake/kg and hospitalizations for HF adjusting for HF risk, energy intake, and dietary factors. The cohort had a mean age=55.3 (SD=12.7 years) and composed of 63.4% women, 21.6% diabetes mellitus, 62.7% hypertension, 7.1% coronary disease, and 2.8% with known HF. When compared with participants in the first quartile of magnesium intake/kg, those with higher magnesium intake (>2.308 mg/kg) had decreased risk of HF admission, with adjusted hazard ratios of 0. 66(95% confidence interval, 0.47-0.94) in the second quartile to 0.47 (95% confidence interval, 0.27-0.82) in the highest quartile. Results were similar when individuals with previously diagnosed HF (2.8%) were excluded or when the analysis was repeated using quartiles of magnesium intake without accounting for body weight. Magnesium intake <2.3 mg/kg was related to increased risk of subsequent HF hospitalizations. Future studies are needed to test whether serum magnesium levels predict risk of HF.

Magnesium Intake and Risk of Self-Reported Type 2 Diabetes among Japanese

Objective: Dietary magnesium intake has been associated with a reduced risk of type 2 diabetes in western populations, but the evidence is limited in Asian populations.Methods: We assessed the relationship between dietary magnesium intake and risk of diabetes in a cohort of 17,592 individuals (6480 men and 11,112 women) aged 40–65, free of a history of diabetes or other chronic disease at the time of the baseline lifestyle survey, who completed a 5-year follow-up questionnaire. Dietary magnesium was calculated by using a validated questionnaire, and the incidence of diabetes was defined by self-report of physician diagnosis. Associations between dietary magnesium and diabetes incidence were evaluated using a logistic regression model.Results: We found 459 self-reported new cases of diabetes (237 men and 222 women) at the 5-year follow-up. Dietary intake of magnesium was inversely associated with age- and body mass index (BMI)–adjusted diabetes incidence in both sexes. In multivariable analysis that adjusted further for cardiovascular risk factors, the association was weakened in both sexes, but the association in total participants remained statistically significant. The odds ratios of diabetes with reference to the lowest quartile of magnesium intake were 0.83 (95% confidence interval [CI], 0.69 to 1.09) for the second quartile, 0.79 (95% CI, 0.59 to 1.07) for the third quartile, and 0.64 (95% CI, 0.44 to 0.94) for the highest quartile of magnesium intake (p for trend = 0.04).Conclusions: Dietary intake of magnesium was associated with a reduced risk of type 2 diabetes in Japanese populations.

The Association between Magnesium Intake and Fasting Insulin Concentration in Healthy Middle-Aged Women

Objective: We assessed the association between magnesium intake and fasting insulin levels in a large cohort of women.Methods: Female nurses free of diabetes, cardiovascular diseases and cancer from the Nurses Health Study provided blood samples between 1989–1990. We selected a sub-sample of 219 women for this analysis. Magnesium intake was assessed by a food frequency questionnaire in 1990 and categorized into quartiles. Cross-sectional geometric means of fasting insulin concentrations by quartiles of magnesium intake were obtained with Generalized Linear Model and adjusted for several risk factors and lifestyle characteristics.Results: After adjustment for age, body mass index (BMI), total energy, physical activity, hours per week spent sitting outside work, alcohol intake, smoking, and family history of diabetes, magnesium intake was inversely associated with fasting insulin concentration. The multivariate adjusted geometric mean for women in the lowest quartile of magnesium intake was 11.0 μU/mL and 9.3 μU/mL among those in the highest quartile of magnesium intake (p for trend = 0.04). The inverse association remained when we considered magnesium from only food sources.Conclusion: Higher magnesium intake is associated with lower fasting insulin concentrations among women without diabetes. Because lower fasting insulin concentrations generally reflect greater insulin sensitivity, these findings provide a mechanism through which higher dietary magnesium intake may reduce the risk of developing type 2 diabetes mellitus.