The running coupling constants and possible unification of the known interaction group product are considered. For fractional and integral quark charges, non-asymptotically-free U(1) gauge and quartic scalar coupling constants are shown not to exceed order unity prior to appropriate embedding mass scales for unification with gravity and for lepton-hadron unification, respectively. Empirical bounds on the mass scale for lepton-hadron unification are shown to be somewhat lower than previously estimated. Essential quartic scalar-field couplings within proposed ${[\mathrm{S}\mathrm{U}(4)]}^{4}$ embedding symmetry are shown to be non-asymptotically-free.
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