The expansion of the Neyriz marble mine into deeper levels caused an unexpected failure particularly in the toes of lower benches. This phenomenon can impact the overall stability of the quarry and results in undesirable environmental and technical consequences. To understand the failure mechanism, a comprehensive study including—laboratory testing, in situ field testing and theoretical analyses are carried out. The theory of the brittle failure which was mainly developed based on the experiences gained during excavation in granite rocks is adopted and augmented in this study to explain the governing mechanism of failure. Mechanical properties of the marble are determined using conventional rock mechanics tests, and the in situ stress field was evaluated using a modified under coring test. Analyzing the laboratory and field data with the available empirical criteria for brittle failure shows that the level of stress in the lower bench is high enough to initiate the brittle failure. Finally, constitutive models developed for this failure mode are adopted in conjunction with numerical modeling to investigate the observed failure in the quarry. Two modeling strategies, based on elastic and elastic–plastic analyses, are considered. Comparing the predicted failure surface with the observed failure profile, it can be concluded that the brittle failure criteria can very well capture the failure mechanism in this marble quarry. This shows that the criteria proposed to describe spalling failure around underground excavation in granite can be effectively employed for assessing the brittle failure in deep open cast and quarry mines in good quality rocks such as marble.