Recently, we have proposed a quark mass matrix model based on U(3) × U(3)[Formula: see text] family symmetry, in which up- and down-quark mass matrices [Formula: see text] and [Formula: see text] are described only by complex parameters [Formula: see text] and [Formula: see text], respectively. When we use charged lepton masses as additional input values, we can successfully obtain predictions for quark masses and Cabibbo–Kobayashi–Maskawa mixing. Since we have only one complex parameter [Formula: see text] for each mass matrix [Formula: see text], we can obtain a parameter-independent mass relation by using three equations for [Formula: see text], [Formula: see text] and [Formula: see text], where [Formula: see text] ([Formula: see text]). In this paper, we investigate the parameter-independent feature of the quark mass relation in the model.