The motion of quantum particles homogeneously constrained to a curved surface is affected by a curvature-induced geometric potential. Here, by extending the thin-layer procedure, we consider the case of inhomogeneous confinement and derive the effective Hamiltonian where an extra effective potential appears. This effective potential is relevant to the ground-state energy perpendicular to the surface and the morphology of the confining potential. Tiny fluctuations in the thickness are envisioned to induce considerable magnitude of the effective potential. To demonstrate the impact of the inhomogeneity, we apply our method to investigate the coherent transport on a cylindrical surface where two helical ditches is imposed on the thickness. Numerical analysis reveals that the inhomogeneity of the confinement significantly affects the transport properties through changing the geometric symmetry of the system. This study develops the method for low-dimensional constrained systems and exhibits the possibility of a new degree of control for waveguiding in nanostructures.
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