In neural networks, the accuracies of its networks are mainly relying on two important factors which are the centers and spread value. Radial basis function network (RBFN) is a type of feedforward network that capable of perform nonlinear approximation on unknown dataset. It has been widely used in classification, pattern recognition, nonlinear control and image processing. Thus, with the increases in RBFN application, some problems and weakness of RBFN network is identified. Through the combination of quantum computing and RBFN provides a new research idea in design and performance improvement of RBFN system. This paper describes the theory and application of quantum computing and cloning operators, and discusses the superiority of these theories and the feasibility of their optimization algorithms. This proposed improved RBFN (I-RBFN) that combined with cloning operator and quantum computing algorithm demonstrated its ability in global search and local optimization to effectively speed up learning and provides better accuracy in prediction results. Both the algorithms that combined with RBFN optimize the centers and spread value of RBFN. The proposed I-RBFN was tested against the standard RBFN in predictions. The experimental models were tested on four literatures nonlinear function and four real-world application problems, particularly in Air pollutant problem, Biochemical Oxygen Demand (BOD) problem, Phytoplankton problem, and forex pair EURUSD. The results are compared to I-RBFN for root mean square error (RMSE) values with standard RBFN. The proposed I-RBFN yielded better results with an average improvement percentage more than 90 percent in RMSE.