We discuss effective interactions among brane matter induced by modifications of higher-dimensional Einstein gravity through the replacement of Einstein–Hilbert term with a generic function f(R,RABRAB,RABCDRABCD) of the curvature tensors. We determine gravi-particle spectrum of the theory, and perform a comparative analysis of its predictions with those of the Einstein gravity within Arkani-Hamed–Dvali–Dimopoulos (ADD) setup. We find that this general higher-curvature quantum gravity theory contributes to scatterings among both massive and massless brane matter (in contrast to much simpler generalization of the Einstein gravity, f(R), which influences only the massive matter), and therefore, can be probed via various scattering processes at present and future colliders and directly confronted with the ADD expectations. In addition to collision processes which proceed with tree-level gravi-particle exchange, effective interactions among brane matter are found to exhibit a strong sensitivity to higher-curvature gravity via the gravi-particle loops. Furthermore, particle collisions with missing energy in their final states are found to be sensitive to additional gravi-particles not found in Einstein gravity. In general, road to a correct description of quantum gravity above Fermi energies depends crucially on if collider and other search methods end up with a negative or positive answer for the presence of higher-curvature gravitational interactions.