SummaryNowadays, smart multimedia network services have become crucial in the healthcare system. The network parameters of Quality of Service (QoS) are widely affecting the efficiency and accuracy of multimedia streaming in wireless environments. This paper proposes an adaptation framework model, which makes a relation between the QP (quantization parameter) in H.264 and H.265 codecs and the QoS of 5G wireless technology. Besides, the effect of QP and packet loss have been studied because of their impact on video streaming. Packet loss of 5G wireless network characteristic is emulated to determine the impact of QP on the received video quality using objective and subjective quality metrics such as PSNR (peak signal to noise ratio), SSIM (structure similarity), and DMOS (differential mean opinion score). In this research, a Testbed is implemented to stream the encoded video from the server to the end users. The application model framework has automatically evaluated the QoE (Quality of Experience). Accordingly, the model detects the defect of network packet loss and selects the optimum QP value to enhance the QoE by the end‐users. The application has been tested on low and high video motions with full high definition (HD) resolution (1920 × 1080) which were taken from ( https://www.xiph.org/downloads/). Test results based on the objective and subjective quality measurements indicate that an optimal QP = 35 and QP = 30 have been chosen for low and high motion respectively to satisfy user QoE requirements.