To evaluate the diagnostic value of whole-tumor quantitative apparent diffusion coefficient (ADC) histogram and texture analysis for differentiation of minimal fat angiomyolipoma (MFAML) from clear cell renal cell carcinoma (ccRCC). We retrospectively reviewed 27 patients with MFAML and 113 patients with ccRCC pathologically proven. All patients performed magnetic resonance imaging (MRI) including diffusion-weighted imaging (b = 0, 800s/mm2). Whole-tumor regions of interest were drawn on all slices of diffusion-weighted imaging to obtain histogram and texture parameters, including the mean ADC, median ADC, 10th, 25th, 75th, 90th percentiles ADC, standard deviation, skewness, kurtosis, and entropy. The Student's t test was used to compare the parameters between MFAML and ccRCC. Receiver operating characteristic curves analysis was used to compare the diagnostic value of each significant parameter. MFAML had significantly lower mean ADC, median ADC, 10th, 25th, 75th, 90th percentiles ADC than ccRCC (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). Skewness of MFAML was significantly higher than that of ccRCC (p = 0.016). However, standard deviation, kurtosis, and entropy were not significantly different (p = 0.409, p = 0.085, p = 0.206, respectively). The 90th percentile ADC generated the highest AUC (AUC, 0.854; Sensitivity, 78.8%; Specificity, 81.5%) for differentiating MFAML from ccRCC. Whole-tumor ADC histogram and texture analysis could be considered a useful and noninvasive method to help differentiate MFAML of ccRCC with higher accuracy.