Quantitative Recording Research Articles

Quantitative record of the Neoarchean water cycle from a 2.67 Ga magmatic-hydrothermal system, Fennoscandian Shield

Given the scarcity of reliable paleoclimate record, the surface temperatures of the first half of Earth’s history remain poorly constrained. Here we show how the climate-sensitive δ18O value of surface precipitation recorded in Archean igneous and hydrothermal formations can help to resolve the state of early Earth climate. The Keivy complex, Kola craton (Fennoscandian Shield), formed via the intrusion of granitic and mafic magmas in the shallow crust at 2.67 Ga, where circulation of meteoric water created a distinct archive of the contemporaneous water cycle. Using whole rock data, mineral separates, and in situ zircon δ18O measurements, we disentangle the reaction mechanisms between the shallow magma and local precipitation. Syn-emplacement hydrothermal alteration produced near-contact lithologies with δ18O values as low as –8‰ recorded in amphiboles, while igneous zircons from granites crystallized from melts with δ18O from +1‰ to +4.5‰. High-precision U-Pb geochronology constrains the granite intrusion at 2673.5 ± 0.3 Ma. Using the Δ17O approach, these rocks reveal that the precipitation had a δ18O value 18‰ lower than the hydrosphere, providing one of the earliest quantitative records of continental precipitation generally compatible with a cold climate at high latitudes.

Quantitative record of the Neoarchean water cycle from a 2.67 Ga magmatic-hydrothermal system, Fennoscandian Shield

Abstract Given the scarcity of reliable paleoclimate record, the surface temperatures of the first half of Earth’s history remain poorly constrained. Here we show how the climate-sensitive δ18O value of surface precipitation recorded in Archean igneous and hydrothermal formations can help to resolve the state of early Earth climate. The Keivy complex, Kola craton (Fennoscandian Shield), formed via the intrusion of granitic and mafic magmas in the shallow crust at 2.67 Ga, where circulation of meteoric water created a distinct archive of the contemporaneous water cycle. Using whole rock data, mineral separates, and in situ zircon δ18O measurements, we disentangle the reaction mechanisms between the shallow magma and local precipitation. Syn-emplacement hydrothermal alteration produced near-contact lithologies with δ18O values as low as −8‰ recorded in amphiboles, while igneous zircons from granites crystallized from melts with δ18O from +1‰ to +4.5‰. High-precision U-Pb geochronology constrains the granite intrusion at 2673.5 ± 0.3 Ma. Using the Δ17O approach, these rocks reveal that the precipitation had a δ18O value 18‰ lower than the hydrosphere, providing one of the earliest quantitative records of continental precipitation generally compatible with a cold climate at high latitudes.

Efficacy and Safety of Transarterial Chemoembolization with DC Beads LUMI in the Treatment of HCC: Experience from a Tertiary Centre.

The aim of this study was to describe the safety and efficacy profiles of TACE using DC Beads LUMI. We retrospectively analyzed 90 patients with HCC who underwent TACE with DC Bead LUMI™ between November 2018 and November 2020 at Fondazione IRCCS Cà Granda Policlinico Hospital in Milan, Italy. Patient- and tumour-related factors were registered, including the number of treated lesions, dose of DC Beads LUMI™, dose of Epirubicin, DC Beads LUMI™ target tumour coverage (LC) according to the percentage of target nodule involvement (LC1-0%-25%, LC2-25%-50%, LC3-50%-75%, LC4 75%-100%). Treatment efficacy was obtained through reviewing the follow-up imaging for evidence of response in target lesion(s), according to modified response criteria in solid tumours (mRECIST) criteria with the following outcomes: complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Safety assessment was based on the quantitative and qualitative recording of the adverse events, classified according to CIRSE classification. Seventy-two patients were enrolled, and 95 procedures were carried out. We observed a target tumour response rate at 1 month with CR in 68%, PR in 10.3% 11.8%, SD in 13%, PD in 7.2%, and an overall tumour(s) (whole liver) response at 1 month with CR in 58.9%, PR in 12.6%, SD in 10.5% and PD in 18%. We found a significant association (p < 0.01) between tumour response CR or CR + PR and the number of the target lesion(s). CIRSE classification grade I and grade II complications were recorded, respectively, in 11 (11.6%) and 6 (6.3%) procedures. No grade III-IV-V complications occurred. TACE using DC Beads LUMI is a safe and effective treatment option for patients with HCC.

Functional performance of children with Myelomeningocele submitted to intrauterine repair and conventional surgery

Introduction: Myelomeningocele (MMC) is an embryonic malformation that occurs in the first four weeks of gestation due to a failure in the closure of the neural tube. They have multifactorial etiology such as genetic and environmental factors that affect folic acid metabolism. Several anomalies may be associated with MMC, with the occurrence of hydrocephalus and Arnold Chiari type II malformation being most present. Surgical repair should ideally occur within the first 24 hours after birth to prevent or decrease the risk of infection, preservation of all viable nerve tissue, anatomical reconstitution. However, surgical repair of MMC intrauterine has shown substantial benefit in all babies submitted to this intervention. Objective: To compare the functional performance of children with MMC who underwent intrauterine surgical repair and those who did traditional surgery at birth. Methods: Cross-sectional study carried out at the UCB School-Clinic, where children treated with MMC were evaluated, analyzing their motor status and functional performance using the Pediatric Evaluation of Disability Inventory (PEDI) for a quantitative record of functional capacity and autonomy in daily activities, in the areas of self-care, mobility and social function. Results: There was a statistically significant relevance on the mobility function (p=0.01) for children who underwent intrauterine repair when compared to children who underwent traditional surgery. Conclusion: There is a strong relationship of better functionality of children who underwent intrauterine surgery when compared to children who underwent traditional surgery.

Pollen-based quantitative paleoclimatic record spanning the Mid-Brunhes Event in the Nihewan Basin, north China

The Middle Pleistocene is an important period of global climatic and environmental evolution during the Quaternary. We conducted pollen analyses of 144 fossil samples and combined 1436 modern surface samples to characterize the processes of vegetation succession and climate change in the Nihewan Basin during the Middle Pleistocene, especially the Mid-Brunhes Event. The results showed that the pollen assemblages during 0.8–0.3 Ma were dominated by herbaceous pollen (> 60%), indicating that the vegetation in the study area was mainly forest steppe. The quantitative climatic reconstruction indicates that annual average temperature (Tann) was generally >6 °C, and annual average precipitation (Pann) was generally >490 mm. The warm climatic conditions persisted for a long interval, and the interval of cold conditions was shorter. Compared with the warm period, during the interval of cold climate Tann decreased by ∼4 °C, and Pann decreased by ∼130 mm. The interval of 0.478–0.424 Ma, Picea dominated the pollen assemblages (> 80%), Tann was generally <2 °C, and Pann was generally <400 mm, which may be a manifestation of the Mid-Brunhes event in the Nihewan Basin, which is corresponded with MIS 12. During this period, Northern Hemisphere insolation and the atmospheric CO2 concentration were low, the Eurasian ice sheet expanded, the winter monsoon strengthened, and the regional climate was cold and dry. The intervals of 0.742–0.478 Ma and 0.424–0.266 Ma were two pronounced warm periods in the Nihewan Basin, which correspond well with MIS 13 and MIS 11, respectively. MIS 13 was the warmest and wettest period during the studied interval, and it may have been related to the unusually strong summer monsoon caused by the climatic asymmetry between the Northern and Southern Hemispheres.

Terrestrial temperature evolution of southern Africa during the late Pleistocene and Holocene: Evidence from the Mfabeni Peatland

The scarcity of suitable high-resolution archives, such as ancient natural lakes, that span beyond the Holocene, hinders long-term late Quaternary temperature reconstructions in southern Africa. Here we target two cores from Mfabeni Peatland, one of the few long continuous terrestrial archives in South Africa that reaches into the Pleistocene, to generate a composite temperature record spanning the last ∼43 kyr. The Mfabeni Peatland has previously been proven suitable for temperature and hydrological reconstructions based on pollen and geochemical proxies. Here we use branched glycerol dialkyl glycerol tetraethers (brGDGTs) preserved in the Mfabeni peatland to derive a new quantitative air temperature record for south-east Africa. Our temperature record generally follows global trends in temperature and atmospheric CO2 concentrations, but is decoupled at times. Annual air temperatures during Marine Isotope Stage (MIS) 3 were moderately high (c. 20.5 °C), but dropped by c. 5 °C during the Last Glacial Maximum, reaching a minimum at c.16–15 ka. Asynchronous with local insolation, this cooling may have resulted from reduced sea surface temperatures linked to a northward shift in the Southern Hemisphere westerly winds. Concurrent with the southward retreat of the westerlies, and increasing sea surface temperatures offshore, warming from minimum temperatures (c. 15.0 °C) to average Holocene temperatures (c. 20.0 °C) occurred across the deglaciation. This warming was briefly but prominently interrupted by a millennial-scale cooling event of c. 3 °C at c. 2.4 ka, concurrent with a sudden change in hydrological conditions. The average Holocene temperatures of c. 20.0 °C were similar to those reconstructed for MIS 3, but after the 2.4 ka cooling period, air temperatures in the Mfabeni peat recovered and steadily increased towards the present. In summary, our record demonstrates that land temperature in eastern South Africa is highly sensitive to global drivers as well as nearby sea surface temperatures.

Alterations in the proteome as a regulating mechanism for patulin stress by the antagonistic yeast Meyerozyma guilliermondii

Meyerozyma guilliermondii is an antagonistic yeast; our research team has recently reported its biocontrol activities against blue mold decay of pears and strong patulin (PAT) reduction ability in vitro. PAT is a harmful mycotoxin produced by some species of Penicillium, Aspergillus, and Byssochlamys. The PAT degradation process and molecular mechanism(s) of M. guilliermondii remain unclear. The data-independent acquisition (DIA) strategies promise a comprehensive, reproducible, digital, qualitative and quantitative record of the proteins present in a sample. Differentially expressed proteins accompanying PAT degradation in M. guilliermondii were observed to investigate PAT reduction mechanisms. The comparative proteomic analysis of M. guilliermondii showed that 136 proteins were up-regulated and 122 were down-regulated upon PAT degradation. The M. guilliermondii's regulation of PAT response mainly includes the up-regulation of (1) growth and reproduction-related protein expression, (2) transcription and translation-related protein expression, (3) resistance-related protein expression, (4) multidrug transporters, (5) anti-oxidative stress-related proteins, (6) the cell wall and cell membrane production-related proteins, and (7) PAT degradation-related protein expression. This paper analyzed M. guilliermondii’s molecular response and regulation upon PAT reduction at the gene and protein expression levels. Our results provide a solid foundation for PAT control in fruits and their products by antagonistic yeasts.

The sight of one's own body: Could qEEG help predict the treatment response in anorexia nervosa?

Aims of the studyThe study aims to identify the differences in brain activity between participants with anorexia nervosa and healthy control using visual stimulus conditions combined with the quantitative dense-array EEG recording analysis method called Brain Activation Sequences (BAS).Materials and methods23 participants with anorexia nervosa and 21 healthy controls were presented with visual stimuli, including the subject’s facial expressions and body images. The 128-channel EEG data were processed using BAS and displayed as activity in up to 66 brain regions. Subsequent cluster analysis was used to identify groups of participants exhibiting area-specific activation patterns.ResultsCluster analysis identified three distinct groups: one including all healthy controls (HC) and two consisting of all participants with anorexia (AN-I with 19 participants and AN-II with four participants). The AN-I and AN-II groups differed in their response to treatment. Comparisons of HC vs. AN confirmed the dominance of the right cerebral hemisphere in participants with anorexia nervosa in two of the three reported conditions. The facial expressions condition, specifically the facial reaction expressing disgust, indicates the existence of a social attentional bias toward faces, whereas emotions remained undetected in participants. High limbic activity, medial frontal gyrus involvement, low fusiform cortex activity, and milder visual cortex activity in healthy controls compared to participants indicate that the facial expression stimulus is perceived by healthy subjects primarily as an emotion, not as the face itself. In the body image condition, participants showed higher activity in the fusiform gyrus and right insula, indicating activation of the brain’s “fear network.”ConclusionThe study describes a specific pattern of brain activation in response to facial expression of disgust and body images that likely contributes to social-cognitive and behavioral impairments in anorexia. In addition, the substantial difference in the pattern of brain activation within the participants with AN and its association with treatment resistance deserves special attention because of its potential to develop a clinically useful prediction tool and identify potential targets for, for example, neuromodulatory treatments and/or individualized psychotherapy.

High Latitude Coral Larval Recruitment: Spatiotemporal Process Variability in the Gulf of California1

The aim of this study is to explore if sexual reproduction is present in scleractinian corals at the northern limit of their distribution (28.980° N, 113.470° W) in a zone subject to upwelling and seasonal variations in sea surface temperature, and sampling was performed from August 2018 to October 2019. We placed 42 terracotta recruitment tiles in Bahía de los Ángeles, Baja California. Coral cover was estimated, and the height, major diameter, and minor diameter of coral colonies were measured. Astrangia haimei and Porites panamensis recruits were identified on the recruitment tiles, constituting the first quantitative record for the northeastern tropical Pacific. Recruitment of P. panamensis was higher (Llave: 63.09 ± 114 ind m–2 y–1, Rasito: 3.21 ± 7 ind m–2 y–1), while A. haimei recruitment at the same sites was 3.85 ± 8 and 1.93 ± 6 ind m–2 y–1, respectively. Recruitment differences between locations were attributed to coral cover (the abundance of Porites panamensis is 15-fold greater in Llave than in Rasito) and colony size (P. panamensis Llave: 10.53 ± 5.93 cm, Rasito: 4 ± 0.63 cm). Both SST and Chl-a concentrations were also highly correlated with coral recruitment, with higher recruitment rates observed in the warmer seasons when high nutrient concentrations were also present. In contrast to other sites in the eastern tropical Pacific, the highest rate of recruitment was reported at this study (high-latitude coral community), which, according with the positive high latitude trend reported by other studies, is likely due to climate change.

Mid-latitude precipitation in East Asia influenced by a fluctuating greenhouse climate during the latest Cretaceous through the earliest Paleogene

Deep-time records from greenhouse climate periods (e.g., the Late Cretaceous) provide a reference point for understanding how high atmospheric CO 2 concentrations influence precipitation in the mid-latitude Northern Hemisphere (e.g., East Asia). In this study, we quantitatively reconstruct mean annual precipitation (MAP) in East Asia during the latest Cretaceous through the earliest Paleogene (~76–65.5 Ma), based on a well-studied paleosol sequence from the Sifangtai and Mingshui Formations from the SK-1n scientific borehole in the Songliao Basin, northeastern China. We use several proxies, including sedimentary-based observational proxies (e.g., depth to the calcic horizon, DTC) and elemental geochemistry proxies in the paleosol B horizon (e.g., the chemical index of alteration minus potassium, CIA-K; the calcium‑magnesium weathering index, CALMAG), which show the consistency with weathering proxies and previously published isotopic records. Changes in the MAP are associated with warming and cooling events. In the warciaming period (e.g., at ~69.5–68.5 Ma), an increase in the land-sea thermal contrast led to an expanded, enhanced, poleward-shifted thermal low-pressure system over the East Asian continent, which triggered an enhanced hydrological cycle and increasing MAP in the Songliao Basin. During the cooling period (e.g., at ~72.5–69.5 Ma and ~68.5–66.5 Ma), weakened East Asian monsoon and strengthened equatorward-shifted westerlies allowed for colder and arid air masses to encroach upon the Songliao Basin, which led to decreased MAP. Changes in MAP across the K-Pg boundary coincide with climate fluctuations and catastrophic geological events. Furthermore, our work compares three warming intervals in deep-time (middle Maastrichtian, late Maastrichtian and earliest Paleogene) with Shared Socio-economic Pathway scenarios used by the IPCC for the end of the 21st century, and indicates MAP increases in East Asia with ongoing anthropogenic CO 2 emissions. • The first high-resolution quantitative precipitation record in mid-latitude East Asia during ~76−65.5 Ma.. • Changes in the mean annual precipitation (MAP) associated with climate fluctuations and catastrophic geological events. • Geological records suggest MAP in East Asia will likely increase under ongoing anthropogenic CO 2 emissions.

Wireless Non-Invasive Monitoring of Cholesterol Using a Smart Contact Lens.

Herein, a wireless and soft smart contact lens that enables real‐time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol‐related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non‐invasive healthcare device.

Evidence for a Relatively Warm Mid‐to Late Holocene on the Southeastern Tibetan Plateau

AbstractThe Holocene temperature discrepancy between paleoclimate reconstructions and climate model simulations—known as the Holocene temperature conundrum—calls for new high‐quality Holocene temperature records at high elevations. Here, we present a quantitative Holocene mean annual air temperature record based on a site‐specific branched glycerol dialkyl glycerol tetraethers calibration from a small remote alpine lake on the southeastern Tibetan Plateau. The record reveals a temperature history comprising a relatively cool early Holocene (before 7 ka) followed by a warmer mid‐ to late‐Holocene (after 7 ka), which was likely linked to increasing local annual insolation and greenhouse gases. Three cold events punctuated the general warming trend ca. 10.4 ka, 3.7 ka, and 1.7 ka BP, and correspond closely in time to ice rafting events in the North Atlantic, and to episodes of volcanism and/or unusual solar activity. The entire Holocene temperatures are cooler than the previously identified anthropogenic warming from 1990–2015 AD.

Influence of water conditions on peat brGDGTs: A modern investigation and its paleoclimatic implications

Peat brGDGTs (branched glycerol dialkyl glycerol tetraether lipids) have been proposed as an indicator of past temperature changes. However, recent Chinese peat brGDGTs-based Holocene temperature ranges, of >10 °C, are implausible as they are greater than the corresponding ranges obtained using other proxies. This indicates the possible role of additional factor(s) affecting peat brGDGTs, other than temperature. Here, we report the results of a comparative study of surface peat samples, from dry sites (without water cover when sampling) and water sites (with water cover when sampling), from three peatlands with contrasting environmental backgrounds in China. The results clearly demonstrate the influence of water conditions on the molecular distribution of peat brGDGTs. Specifically, the relevant methylation index (MBT′/MBT′5ME, which is proposed as a temperature indicator) of brGDGTs from the water sites is generally lower than that from the dry sites, which may be caused by the decoupling of water/air temperatures and/or different brGDGTs-producing bacterial communities controlled by the water conditions. Considering the long-term process of hydroseral succession from a water body (an analogue of a water site) to a peat bog (an analogue of a dry site), we estimate that around half of the range of the peat brGDGTs-based Holocene temperature record could result from long-term changes in hydrological conditions. If this effect is removed from the peat core MBT′5ME record, the residual range of the peat brGDGTs-based Holocene temperature record from the Narenxia peatland in the Altai Mountains, in arid inland China, is consistent with that of the quantitative pollen-based Holocene temperature record from the same peatland, highlighting the paleoclimatic significance of our findings.

Αξιολόγηση Προγράμματος Υγείας Κοινωφελούς Επιχείρησης για την Αποφυγή Παραγόντων Κινδύνου για την Υγεία

This study investigated the effectiveness of the “Community Center’s Health Program” administered by a Municipal Enterprise aiming to reduce health risk factors (alcohol, smoking, diet, exercise), in 351 participants, implemented during a five-year period (2015-2020). For this purpose, quantitative and qualitative personal record data were examined. According to the results a) alcohol users decreased (- 1.20%), b) smokers decreased (-0.50%) while there was also a tendency for heavy smokers to reduce to 1-10 cigarettes per day, c) percentage of those who systematically exercise decreased (-4.90%, p=0,001&lt;0,05) while frequency of desired exercise increased (+54.40%) for those who already exer- cised, d) overall food consumption reduced while there was compliance with dietary guidelines at "sweets" (+1.70%, p= 0.044 &lt;0.05) and "salt" (+ 1.20%) categories, e) course of the disease improved in 8 out of 10 disease categories ("Cancer": -2%, p= 0.039 &lt;0.05, "Gastroenterological diseases": -2.9%, p= 0.002 &lt;0.05) while within the desired limits remained the Mean of Blood Sugar (+0.81%, p= 0.030 &lt;0.05), Total Choles- terol (-2.50%) and Blood Pressure (Systolic Blood Pressure -0, 91%, Diastolic Blood Pressure -1.15%). Overall, health for part of the sample was maintained or improved. The Health Program offers indications as to its effectiveness. It can become, through improvements, an original and competent model providing community health care, filling the education gap, and patient monitoring as a reference to chronic disease management, with potentially positive results for the health system.

Use of quantitative electroencephalography as a marker of severity of patients with autism spectrum disorder

Autism spectrum disorder is a neurodevelopmental disorder with increasing prevalence over the past years. Its grading depends on a time-consuming Scales like CARS, ADOS and GARS scales. Our aim is to study if quantitative EEG can be used as a marker of ASD severity. This is a cross sectional study conducted in the period from September 2021 till March 2022. It included 53 patients (41 males and12 females, with age ranging between 3 and 12 years) diagnosed by an experienced psychiatrist according to DSM5 criteria. Patients were recruited from 4 autism centers in Al-Hillah city. All patients were assessed by history, physical examination and Gilliam autism rating scale (GARS 3). Then they undergo quantitative electroencephalographic recording in awake state. The study results showed that spectral power of delta wave both total and regional were significantly increased as the severity of ASD symptoms increased, while alpha spectral power was decreased with increasing severity of ASD. Beta and theta spectral power was unchanged. Also, at cut off value of power spectrum of delta of =27 Mv, give 75% sensitivity and 100 specificity for grading severe ASD.

Use of the posturography in balance system evaluation in occupational medicine

The posturography test allows assessment of the entire function of balance system and quantitative, device-based verification of the clinical Romberg test. Therefore, the aim of this study is assessment of usefulness of posturography as primary test for balance disorders in occupational medicine. The study is cross-sectional, analyzing anonymous results of 1030 patients reporting dizziness and balance disorders. Based on symptoms, clinical examination and videonystagmography patients were classified into subgroups: benign paroxysmal positional vertigo (BPPV [N = 130]), non compensated (NS [N = 82]) and compensated (S [N = 174]) peripheral vestibular, bilateral vestibular (BV [N = 63]), Ménière's disease (MD [N = 53]), central dizziness (central [N = 293]), migraine (migr. [N = 132]), psychogenic dizziness (psychog. [N = 232]), Persistent postural-perceptual dizziness (PPPD [N = 150]). Besides, 129 healthy people were included in the study. Ninety nine percent of abnormal static posturography (SP) and 94% of abnormal dynamic posturography (PD) results were found in diseased patients. Normal results were found both in healthy group (59% PS, 67% PD) and in diseased group (24% PS, 31% PD). Static posturography's abnormal results were more frequent in NS, BV and PPPD patients. In PD the differences were visible in the central, psychog. and PPPD subgroups. In NS subgroup the high negative predictive values of static and dynamic tests (82-87%) were calculated in relation to caloric test. Static tests are the basic test used in examinations of employees for occupational medicine purposes. Posturography is a quantitative record of sways in relation to normative values. Abnormal posturography results most likely indicate the presence of pathologies of the balance system, including psychofunctional disorders. Normal posturography results do not indicate the lack of pathology of balance system what should be included in the work ability assessment. Med Pr. 2022;73(2):143-50.

Research on the Construction of College Football Classroom Practice Teaching System Model Based on Big Data Analysis

With the rapid development of information technology, the traditional single classroom teaching and passive learning methods of students can no longer meet the needs of all-round development of college students, and its urgent need to integrate with information technology. This article is aimed at the problem of lagging feedback on training results in the traditional teaching model, teachers' active control, students' passive obedience, ignoring the development of students' personality in college football classrooms, and the inability to carry out personalized tracking and quantitative improvement of the training process of students' related abilities. We constructed a college football classroom practice teaching system model based on big data analysis from the perspectives of establishing big data teaching resources, and implementing personalized resource recommendation, optimizing the traditional teaching process, integrating quantitative training, measurement and recording, implementing quantitative intervention, etc. Colleges and universities have carried out experimental observations. Through continuous observation and comparison, it is found that college football classroom practice teaching under big data is more conducive to improving students' football skills and theoretical level than traditional teaching. This model makes full use of the advantages of big data and the combination of practical teaching methods, which can bring students a different learning experience and obtain good teaching effects. It has guiding and reference significance for college football practical teaching.

Model of delivery of cancer care in South Africa’s Eastern Cape and Mpumalanga provinces: a situational analysis protocol

IntroductionCancer contributes to a significant proportion of morbidity and mortality globally. Low-income and middle-income countries such as South Africa tend to be characterised by poor and inequitable access to cancer...

Low-δ18O Neoarchean precipitation recorded in a 2.67 Ga magmatic-hydrothermal system of the Keivy granitic complex, Russia

The modern hydrological cycle includes precipitation of 18O-depleted meteoric water over continental crust exposed above sea-level. How far back in the geological record can continental exposure be documented remains uncertain, particularly for the Archean. To investigate the extent of Archean continental exposure, we document a newly discovered low-δ18O magmatic-hydrothermal system that was emplaced in a shallow crust of the Keivy complex, Kola craton at 2.67 Ga. This study builds a case for syn-emplacement hydrothermal exchange with the local meteoric water that had δ18O at least as low as −11‰ VSMOW. Coupled with the high-latitude position of the Kola craton at the time, this result presents a paleogeographic documentation of continental exposure and a quantitative estimate of the isotope composition of Neoarchean precipitation. We employ detailed δ18O mapping using mineral separates and bulk samples, as well as ion microprobe δ18O measurements and U-Pb dating of zircon. The spatially extensive O-isotope dataset (n = 63) spans over 120 km in length across different lithological units including the peralkaline granites of the Keivy complex, the hosting gneiss and contact hydrothermal quartzolites. All analyzed samples, including whole rock samples and mineral separates, show δ18O below those expected for mantle- and crust-derived magmas. The lowest δ18O of ca. −7‰ are measured in minerals and bulk rock of the altered gneisses near the intrusive contacts. Peralkaline granites returned δ18O values ranging between −6 and +5‰. Zircon crystals with preserved igneous zoning have low δ18O = +2.2‰ and yield an emplacement age for the magmatic complex of 2672 ± 7 Ma. Zircon dating from quartzolites at the contact between granites and country gneisses points to fluid-rock interaction at 2.67 and at 1.77–1.79 Ga. We propose that the spatially extensive O-isotope depletion documents a Neoarchean shallow magmatic-hydrothermal system where magmatic assimilation produced the low-δ18O granites and the hydrothermal cycling of meteoric water in the ambient crust resulted in formation of low-δ18O altered host rocks. Since the lowest δ18O value measured in a rock is ca. −7‰, the equilibrium fluids had δ18O of around −9‰ under hydrothermal conditions (300-400°C) characteristic for the shallow crust around cooling intrusions. Considering that hydrothermal fluids are shifted 1-2‰ towards higher values, the contemporaneous precipitation had δ18O = −11‰ or lower. Consequently, the 2.67 Ga Keivy complex is the earliest known intact low-δ18O magmatic-hydrothermal system offering a quantitative record of the Neoarchean precipitation that can be used as a tool in paleogeographic reconstructions.

PERANCANGAN SISTEM INFORMASI ANALISIS KUANTITATIF REKAM MEDIS RAWAT INAP DI RUMAH SAKIT BHAYANGKARA KOTA BENGKULU

This research aims to make design of system information design by quantitative analysis of medical records inpatient in Rumah Sakit Bhayangkara Kota Bengkulu.The method used in this research is qualitative research method which is a direct research method, such as data collection, field study and literature study, which is related to research problem, while software development using waterfall method with unified modeling language (UML) as design of software. Programming language used is PHP and database used is MySQL. Based on the research, various problems are found: quantitative analysis of medical records is not well computerized and reports have not been implemented properly. The suggestions given are: 1) the design of information system of quantitative analysis of medical record to optimize quantitative medical record analysis and recapitulation report of result of quantitative analysis, 2) maintain and develop information system of quantitative analysis of medical record and 3) follow up to doctors or an officer for completing an incomplete medical record form.&#x0D; Keywords: Design, system information, medical record, php and MySQL.