Abstract Quantitative health impact appraisal for land use development is currently challenging. We show how a co-designed process between urban decision makers and academics can help to improve ways of deriving evidence for creating healthier cities. The Health Appraisal of Urban Systems (HAUS) economic valuation model was developed with local partners to inform a strategic framework for a UK urban regeneration site. HAUS is a comparative risk assessment model which allows the user to understand mechanisms for change through applying an impact-pathway approach to quantify changes in health. It is informed by systematic reviews of epidemiology and societal costs of 85 individual health end-points. Scenarios combined a range of characteristics including air and noise pollution, green space, crime, walkability, food environment and transport. Health outcomes include morbidity and mortality impacts. Results show the value of a holistic approach to comparing health risks in designing urban living. By monetising outcomes, practitioners were able to understand the relative magnitude of risk within a specific area and compare alternate urban development scenarios. Compared to an unmanaged development, the Strategic Framework can mitigate health risks by improving safety and quality of the public realm and add health benefits by encouraging activity and active commuting. Flood risks are managed, and green infrastructure improved and extended. These benefits extend to communities outside the site boundaries. Over 25 years, the PV benefits are £60 - 80 million in averted health costs. Strategic planning for urban areas can unlock the potential of the public realm to tackle health inequalities and mitigate serious risks to public health. Timely access to quantitative information on health can help inform understanding of unhealthy environments, strengthen arguments for good design, reinforce capacity of planning teams and so improve the quality of urban developments. Speakers/Panelists Odile Mekel NRW Centre for Health, Bochum, Germany