Quantitative Analysis Research Articles

Efficiency and safety of single anastomosis sleeve ileal (SASI) bypass in the treatment of obesity and associated comorbidities: a systematic review and meta-analysis.

The Single Anastomosis Sleeve Ileal (SASI) bypass is a new bariatric surgery corresponding to an adaptation of the Santoro approach, consisting of a sleeve gastrectomy (SG) followed by loop gastroileostomy. Therefore, we aimed to systematically assess all the current literature on SASI bypass in terms of safety, weight loss, improvement in associated comorbidities, and complications. Following the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) recommendations, we conducted a systematic review and meta-analysis by searching three databases (PubMed, Scopus, and Web of Science). We performed a meta-analysis of risk ratios and mean differences to compare surgical approaches for excessive weight loss, improvement/remission in type 2 diabetes mellitus (T2DM), hypertension (HT), dyslipidemia (DL), obstructive sleep apnea (OSA), and complications. Heterogeneity was assessed using the I2 statistic. Eighteen studies were included in the qualitative analysis and four in the quantitative analysis, comparing SASI bypass with SG and One-Anastomosis Gastric Bypass (OAGB). A comparison between Roux-en-Y Gastric Bypass (RYGB) and SASI bypass could not be performed. Compared to SG, the SASI bypass was associated with improved weight loss (MD = 11.32; 95% confidence interval (95%CI) [7.89;14.76]; p < 0.0001), and improvement or remission in T2DM (RR = 1.35; 95%CI [1.07;1.69]; p = 0.011), DL (RR = 1.41; 95%CI [1.00;1.99]; p = 0.048) and OSA (RR = 1.50; 95%CI [1.01;2.22]; p = 0.042). No statistically significant differences in any of the assessed outcomes were observed when compared with OAGB. When compared to both SG and OAGB, the complication rate of SASI was similar. Although studies with longer follow-up periods are needed, this systematic review and meta-analysis showed that SASI bypass has a significant effect on weight loss and metabolic variables. Variations in outcomes between studies reinforce the need for standardization.

A protective mechanism of heat inactivation to enhance Levilactobacillus brevis PDD-2 against alcohol-induced chronic liver disease based on proteomic analysis.

A proteomics-based analysis of the effect of heat inactivation on the alleviation of alcoholic liver disease (ALD) using Levilactobacillus brevis PDD-2 is presented, aimed at exploring the potential and mechanisms of postbiotic elements prepared through heat inactivation in the treatment of ALD. It was found that L. brevis PDD-2 and its postbiotic (heat-inactivated L. brevis PDD-2) alleviate chronic ALD via the gut-liver axis. In particular, heat-inactivated L. brevis PDD-2 significantly increased the relative abundance of Erysipelotrichaceae and better facilitated the oxidative stress balance in the liver. The tandem mass tag (TMT)-based quantitative proteomics technique analyses revealed that heat-inactivated L. brevis PDD-2 was associated with up-regulated expression levels of proteins related to the redox system, cellular metabolism, amino acid and oligopeptide transport, and surface proteins with immunomodulatory capacity. These findings provide a theoretical basis for developing novel therapeutic strategies and lay a solid foundation for further revealing its exhaustive mechanisms.

Flavonoid as a Potent Antioxidant: Quantitative Structure-Activity Relationship Analysis, Mechanism Study, and Molecular Design by Synergizing Molecular Simulation and Machine Learning.

In this work, a quantitative structure-antioxidant activity relationship of flavonoids was performed using a machine learning (ML) method. To achieve lipid-soluble, highly antioxidant flavonoids, 398 molecular structures with various substitute groups were designed based on the flavonoid skeleton. The hydrogen dissociation energies (ΔG1, ΔG2, and ΔG3) related to multiple hydrogen atom transfer processes and the solubility parameter (δ) of flavonoids were calculated using molecular simulation. The group decomposition results and the calculated antioxidant parameters constituted the ML data set. The artificial neural network and random forest models were constructed to predict and analyze the contribution of the substitute groups and positions to the antioxidant activity. The results showed the hydroxyl group at positions B4', B5', and B6' and the branched alkyl group at position C3 in the flavonoid skeleton were the optimal choice for improving antioxidant activity and compatibility with apolar organic materials. Compared to the pyrogallol group-grafted flavonoid, the designed potent flavonoid decreased ΔG1 and δ by 2.2 and 15.1%, respectively, while ΔG2 and ΔG3 kept the favorable lower values. These findings suggest that an efficient flavonoid prefers multiple ortho-phenolic hydroxyl groups and suitable sites with hydrophobic groups. The combination of molecular simulation and the ML method may offer a new research approach for the molecular design of novel antioxidants.

Service Oikos as a complex self-perpetuating system: a bibliometric study of service ecosystems

PurposeThis study aims to address the following research questions: (1) What are the theoretical frameworks and areas of study that influence the development of service ecosystems? and (2) To what extent does a service ecosystem align with the theoretical concepts presented in other research contexts within the study areas, thereby transforming the fundamental structure of the core concept?Design/methodology/approachWe conducted a bibliometric systematic literature review, analyzing 280 papers from a sample of 52 journals listed in the Association of Business Schools (ABS). The review covered the period between 2004 and 2022, and we utilized co-citation analysis, multi-dimensional scaling analysis and hierarchical cluster analysis (HCA) on a total of 2,614 citations.FindingsThis study employs co-citation analysis to identify the conceptual structure of the service ecosystem based on highly cited papers. Additionally, we utilize multidimensional scaling (MDS) to uncover key approaches driving service ecosystem research. Through HCA and network analysis, we examine the research scope and its development, emphasizing theory-driven approaches. By combining quantitative and qualitative analysis, we explore the interrelationships between scope, domain and evolution. This comprehensive analysis allows us to delve deeply into the study of service ecosystems. To broaden the research scope, we propose a conceptual framework for comparing the main components of a service ecosystem. The current paper clarifies the service ecosystem's intellectual structure, including service performance, humanistic approach, sustainable innovations and service reflexivity and reformation and proposes a prospective research framework for specialists and researchers by introducing a metaverse service ecosystem.Originality/valueFor the first time, the findings of this study shed light on processes that facilitate the flow of technologies, business models and markets through social structures, ultimately contributing to social change. In service-based systems, the development and application of a more humanistic approach within and surrounding social service ecosystems are crucial as they evolve. Therefore, adopting a dynamic and multifaceted approach offers valuable insights into the drivers of value creation.

Social Media Users' Engagement with Fear Appeal Elements in Government's Health Crisis Communication via State-Owned Media.

Government health messaging is significant to the containment of public health crises. Such communication may benefit from using fear appeal, a message strategy for promoting health and preventing diseases. Yet little scholarly attention has been paid to how fear appeal is employed in government messaging to promote social media engagement through online actions including likes, shares, and comments. These actions play a meaningful role in addressing communication exigencies within the context of health crises. In this study, quantitative content analysis and corpus linguistics methods were employed to analyze fear appeal-related elements in COVID-19 messages sent by a state-owned media outlet on social media. The results show that when compared to messages without threat, messages conveying threat elicited significantly more comments, in which emotions and perceptions to threat and efficacy were exhibited, while messages containing both threat and efficacy generated more engagement in comparison to messages with threat alone. Moreover, while subdimensions under efficacy were positive predictors of engagement, those under threat were primarily found to have exerted negative effects. The findings provide insights into how fear appeal elements can be employed in government health crisis communication to engage the public.

Oldest record of a crown anomaluroid rodent from sub-Saharan Africa: a new genus and species from the early Oligocene Topernawi formation of northern Kenya

ABSTRACT Anomaluroid rodents (i.e. Anomaluridae + Zenkerellidae) have a long evolutionary history in Africa dating back to at least the middle Eocene, but Palaeogene fossil members of the anomaluroid crown group have never been found south of the Sahara. Here, we describe the oldest crown anomaluroid from sub-Saharan Africa, Eliwourus topernawiensis (new genus and species) from the early Oligocene Topernawi Formation of northern Kenya. Bayesian phylogenetic tip-dating analysis of a combined molecular-morphological dataset places ~29.5 Ma Eliwourus as an advanced stem anomalurid, and suggests that crown Anomaluridae originated ~28.2 Ma. The gliding behaviour seen in all crown anomalurids had, therefore, likely evolved before the close of the early Oligocene. Bayesian geocoordinates analysis places the origin of crown Anomaluroidea (~47.2 Ma) in northern Africa, and identifies a stem anomalurid dispersal into equatorial eastern Africa in the latest Eocene or earliest Oligocene. We present the first quantitative analysis of the pace of anomaluroid dental evolution and confirm a remarkably slow or bradytelic rate of phenotypic change, despite significant transformations in postcranial morphology related to the evolution of gliding behaviour during the same interval. The Topernawi area was evidently sufficiently forested during the early Oligocene to support both arboreal rodents and primates.

Effective analysis of remote ship inspection in Asia-Pacific region and its impact on shipping trade under COVID-19

ABSTRACT In the wake of the COVID-19 pandemic, the global shipping industry has faced unprecedented challenges, necessitating rapid adaptations in regulatory practices and inspection methodologies to ensure the continuity of trade and maritime safety. Remote port state control (PSC) involves the use of technology to monitor, regulate, and manage the activities and compliance of vessels in a port’s jurisdiction without the need for physical boarding or inspection. This study examines the effectiveness of remote PSC inspections within the Asia-Pacific region and assesses their impact on shipping trade during the pandemic. Utilizing a comprehensive analysis of data from remote inspections conducted under the auspices of the Tokyo Memorandum of Understanding (MOU), this research identifies key factors influencing the efficacy of such inspections and their implications for regulatory compliance and maritime safety. Through a methodological blend of quantitative analysis and qualitative evaluation, the study explores how remote inspections have been critical in maintaining operational integrity and safety standards amidst global disruptions. The findings highlight the role of the International Maritime Organization (IMO) in facilitating these adaptations, alongside the challenges and opportunities of remote inspection practices. This research contributes to the ongoing maritime safety and regulation discourse, offering insights into the potential for remote inspections to complement traditional methods in a post-pandemic world.

Deliberate ignorance towards green tourism: the role of psychological detachment

ABSTRACT The foundational comprehension of the deliberate ignorance of green/sustainable services from the tourist’s standpoint has been significantly overlooked. Thus, this research aims to testify to the effects of stimuli (information overload and pessimism) on deliberate ignorance towards green tourism. This investigation is grounded in an integration of stimulus-organism-response theory, Cognitive Avoidance Theory and Cognitive Load Theory, with a particular focus on the mediating role of psychological detachment. A quantitative analysis was carried out through a questionnaire in which data was collected from 180 tourists. Structural equation modelling was conducted to examine the hypotheses. The results of this work found that environmental stimuli significantly increased tourists’ psychological detachment towards green services. Furthermore, tourists’ psychological detachment mediated the link between stimuli and deliberate ignorance as an outcome construct. This study suggests that practitioners should pay close attention to the environmental stimuli that may influence tourists’ psychological detachment and subsequently deliberate ignorance action towards green tourism. The present study pioneers the examination of the credible empirical influence of stimuli on tourists’ psychological detachment, subsequently contributing to deliberate ignorance towards green tourism.

The Association between Problematic Instagram Use, Psychological Distress, and Well-Being: A Systematic Review and Meta-Analysis.

Recent studies have indicated the potential detrimental psychological effects of Instagram use (IU) and problematic Instagram use (PIU). PIU and IU have been associated with depression, anxiety, and negative general well-being. This study aimed to investigate that correlation through a systematic review and meta-analysis. Sevendatabases, including PubMed/MEDLINE, were explored in February of 2023. Studies that assessed the association between IU and/or PIU with depression, anxiety, other psychological distresses, and/or general well-being were deemed eligible. The Hunter-Schmidt random effects model and multilevel meta-analysis were appliedto assess the outcomes of interest. A total of 1,927 hits were identified with 37 studies included in the quantitative analysis after removal of duplicates and screening of abstracts and full texts, with the total number of participants at 14,305. The obtained correlations between PIU and depression, anxiety, and well-being with 95% confidence interval were found to be r = 0.35, [0.25, 0.44], r = 0.31, [0.22, 0.40], r = -0.17, [-0.24, -0.10], respectively. Similarly, for IU and depression r = 0.11, [0.06, 0.16], p < 0.05 for all of the aforementioned results. The association between IU and anxiety was found to be r = 0.12, [0.04, 0.21], p < 0.05. The present meta-analysis found significant conceptual heterogeneity across the studies included due to different study designs and population heterogeneity. The results show a positive association of PIU and IU with depression, anxiety, and other psychological distress(es). There is a need for robust designed longitudinal research to explore this association.

Normative longitudinal EEG recordings during sleep stage II in the first year of age

The electroencephalogram (EEG) is a fundamental diagnostic procedure that explores brain function. This manuscript describes the characteristics of a sample of healthy at-term infants. One hundred and three (103) infants from Mexico between 15 days and 12.5 months of age were recorded during physiological sleep. Referential EEG recordings were obtained using linked ear lobes as reference. The amplifier gain was 10,000, the bandwidth was set between 0.3 and 30 Hz, and the sample rate was 200 Hz. Sample windows of 2.56 s were marked for later quantitative analysis. To our knowledge, this is the first dataset of normal infants during the first year of age.

Widefield polarization-resolved second harmonic generation imaging of entire thyroid nodule sections for the detection of capsular invasion

The identification of tumor capsular invasion as a sign of malignancy is currently employed in traditional histopathology routines for thyroid nodules. However, its limitations are associated with the assessment criteria for invasion, which often lead to disagreements among observers. The aim of this paper is to introduce a widefield imaging technique combined with quantitative collagen analysis to identify areas of capsular invasion in thyroid neoplasms. In this study, we introduce the application of widefield polarization-resolved second harmonic generation microscopy for imaging entire thyroid nodule sections on histological slides. We employ a cylindrical collagen model to extract parameters associated with the ultrastructure and orientation of collagen within the entire capsule of the thyroid nodule. We showcase the effectiveness of these parameters in distinguishing between areas of nodule capsule invasion and unaffected regions of the capsule through statistical analysis of individual parameters and employing a machine learning technique that involves generating maps via cluster analysis. Our results suggest that quantitative analysis facilitated by polarization-resolved widefield second harmonic generation microscopy could prove beneficial for the automated evaluation of capsular invasion sites in thyroid pathology.

Chemical defences indicate bold colour patterns with reduced variability in aposematic nudibranchs.

The selective factors that shape phenotypic diversity in prey communities with aposematic animals are diverse and coincide with similar diversity in the strength of underlying secondary defences. However, quantitative assessments of colour pattern variation and the strength of chemical defences in assemblages of aposematic species are lacking. We quantified colour pattern diversity using quantitative colour pattern analysis (QCPA) in 13 dorid nudibranch species (Infraorder: Doridoidei) that varied in the strength of their chemical defences. We accounted for the physiological properties of a potential predator's visual system (a triggerfish, Rhinecanthus aculeatus) and modelled the appearance of nudibranchs from multiple viewing distances (2 and 10 cm). We identified distinct colour pattern properties associated with the presence and strength of chemical defences. Specifically, increases in chemical defences indicated increases in colour pattern boldness (i.e. visual contrast elicited via either or potentially coinciding chromatic, achromatic and/or spatial contrast). Colour patterns were also less variable among species with chemical defences when compared to undefended species. Our results indicate correlations between secondary defences and diverse, bold colouration while showing that chemical defences coincide with decreased colour pattern variability among species. Our study suggests that complex spatiochromatic properties of colour patterns perceived by potential predators can be used to make inferences on the presence and strength of chemical defences.

Assessing and enhancing university students’ knowledge integration in learning electromagnetic induction

ABSTRACT Electromagnetic induction stands as a fundamental concept in electromagnetism and has been extensively studied in physics education. In this research, a conceptual framework model is developed to explore university students’ understanding of electromagnetic induction through the lens of knowledge integration. Building upon the experts’ viewpoints and a comprehensive literature review on students’ challenges and misconceptions, a conceptual framework for electromagnetic induction is established, serving as the guidance for developing a concept test to assess levels of knowledge integration in student learning. According to both quantitative and qualitative analyses, the findings confirm that the conceptual framework can proficiently depict the different integration levels of students’ knowledge structures, while also revealing the intricate pathways that underlie their reasoning processes. Drawing from the conceptual framework and insights gained through assessment, an instructional intervention is designed with the specific goal of promoting knowledge integration by highlighting the central idea of electromagnetic induction and connecting it to other knowledge components. The score changes of pre–post testing indicate that the modified instruction has achieved success in improving knowledge integration and deep learning of electromagnetic induction.

Dubbing of English animated series into Arabic on Shahid and Netflix: an analysis based on the politeness theory

PurposeDrawing on the politeness theory, this study explored the dubbing of English children's cartoons into Modern Standard Arabic, focusing on negative face speech acts such as compliments, suggestions, rejections, and suggestions in rejections.Design/methodology/approachThrough quantitative and qualitative comparative analyses, this study investigated the influence of cultural differences on the selection of dubbing strategies, analyzed the politeness strategies employed in dubbing, and examined the maintenance of pragmatic equivalence in translated speech acts. Data were collected from the cartoon series “The Loud House” from popular digital platforms Shahid and Netflix, chosen for their regional (the Arab world) and global popularity, respectively.FindingsThe findings revealed shifts and adaptations in the dubbing process influenced by linguistic and cultural factors, particularly emphasizing social norms and power dynamics (e.g. respect for elders) prevalent in the Arab culture. Translators strategically employed politeness strategies, such as off-record and bald on-record strategies, to ensure cultural appropriateness and maintain the integrity of familial relationships depicted in the content. The comparative analysis of translators' approaches on Shahid and Netflix platforms highlights significant differences in the translation of negative face-threatening act scenarios. Netflix shows a tendency to adjust politeness pragmatic levels to better suit the preferences of the target audience, indicating a proactive effort to enhance viewer engagement through effective translation strategies. In contrast, Shahid adopts a more conservative approach, maintaining a consistent politeness level in its translations, which aligns closely with cultural norms and expectations. This comparative analysis underscores the divergent translation strategies employed by the two platforms, with Netflix prioritizing adaptation to audience preferences and Shahid favoring preservation of established politeness levels. The cultural social factors that influenced the translation and adaptation of face threatening acts can be grasped by considering elements such as social distance, power dynamics, and relative imposition. In Arabic culture, these factors play a crucial role in determining the social dynamics and interactions between individuals. The observed patterns of shifts and adaptations in the translation of face threatening acts on Shahid and Netflix reflect the nature of stratified Arabic societies where communal relationships are defined by factors like family ties, elder-younger dynamics, and friendships. These cultural factors shape the social norms and expectations surrounding face threatening acts, which, in turn, influence the translation choices made on these platforms.Research limitations/implicationsThe study has several limitations that need acknowledgment. Firstly, the sample size was limited, focusing on the dubbing of only two versions of an animated series and four seasons, comparing translations across two platforms. Additionally, there were challenges related to the accessibility and availability of data, with limited information about the translators involved in the dubbing process. Furthermore, the study's focus on specific types of translations may have overlooked other important factors influencing translation practices. Lastly, regional variations in translation practices within the Arab world were not considered. Despite these limitations, the study provides valuable insights into translation practices in animated series on Shahid and Netflix platforms, highlighting the need for future research to address these limitations and provide a more comprehensive understanding of translation practices in the Arab world.Practical implicationsThe findings of this study have significant practical implications for a wide range of stakeholders, including translators, educators, textbook writers, and even non-specialists. For translators, especially those working in the field of audiovisual translation, understanding the nuances of politeness strategies and their application in different cultural contexts is essential. The findings suggest that translators should be sensitive to cultural and social factors when translating negative face-threatening act scenarios in cartoons. By making strategic decisions to adapt translations to align with audience preferences while still preserving cultural appropriateness, translators can enhance viewer engagement and ensure that the translated content resonates effectively with the target audience. Educators and textbook writers can also benefit from these findings by incorporating insights into politeness theory and cross-cultural communication into their curriculum and materials. By teaching students about the importance of politeness strategies in translation and providing them with practical examples and exercises, educators can help prepare the next generation of translators to navigate complex linguistic and cultural challenges in their work. Additionally, non-specialists, such as viewers of translated content, can gain a better understanding of the intricacies involved in translation and the impact of cultural factors on communication. By being aware of these issues, non-specialists can become more discerning consumers of translated media and appreciate the skill and artistry involved in the translation process.Originality/valueThis study underscores the cultural competence and sensitivity of Arab translators in navigating linguistic and social dynamics, contributing to the creation of culturally resonant and entertaining content for young Arabic-speaking audiences.

A hemicyanine-based near-infrared fluorescent probe with large Stokes shift for non-invasive bioimaging of brown adipose tissue.

Brown adipose tissue (BAT), characterized by the presence of numerous mitochondria, plays a key role in metabolism and energy expenditure. Accurately reporting the presence and activation of BAT is beneficial to study obesity, diabetes, and other metabolic disorders. Near-infrared (NIR) fluorescence imaging has the advantages of high sensitivity, non-radioactivity, and simple operation. However, most NIR probes for BAT imaging exhibit small Stokes shifts, which may lead to self-quenching, reducing the signal-to-noise ratio, and introducing cross-talk. Herein, we rationally designed and synthesized a series of hemicyanine-based NIR fluorescent probes HCYBAT-1-3. Among them, HCYBAT-1 demonstrated favorable properties such as near-infrared emission (776 nm), large Stokes shift (139 nm), good biocompatibility and specific mitochondrial targeting (Pearson's colocalization coefficient of 0.87). Meanwhile, HCYBAT-1 was successfully employed to differentiate BAT from white adipose tissue (WAT). Quantitative analysis of NIR fluorescent images showed that HCYBAT-1 could be used for real-time monitoring of BAT activation in mice stimulated by norepinephrine (NE) and cold exposure. Overall, probe HCYBAT-1 showcased its efficacy in non-invasive evaluation of BAT metabolism in vivo with high selectivity and sensitivity.

Analysis of glycoalkaloid distribution in the tissues of mealworm larvae (Tenebrio molitor)

Solanine (SOL) and chaconine (CHA) are glycoalkaloids (GAs) produced mainly by Solanum plants. These plant secondary metabolites affect insect metabolism; thus, they have the potential to be applied as natural plant protection products. However, it is not known which GA concentration induces physiological changes in animals. Therefore, the aim of this study was to perform a quantitative analysis of SOL and CHA in the larvae of Tenebrio molitor using LC‒MS to assess how quickly they are eliminated or metabolised. In this experiment, the beetles were injected with 2 μL of 10−5 M SOL or CHA solution, which corresponds to a dosage range of 0.12–0.14 ng/mg body mass. Then, 0.5, 1.5, 8, and 24 h after GA application, the haemolymph (H), gut (G), and the remainder of the larval body (FB) were isolated. GAs were detected in all samples tested for 24 h, with the highest percentage of the amount applied in the FB, while the highest concentration was measured in the H sample. The SOL and CHA concentrations decreased in the haemolymph over time, while they did not change in other tissues. CHA had the highest elimination rate immediately after injection, while SOL slightly later. None of the GA hydrolysis products were detected in the tested samples. One possible mechanism of the detoxification of GAs may be oxidation and/or sequestration. They may be excreted by Malpighian tubules, with faeces or with cuticles during moulting. The results presented are significant because they facilitate the interpretation of studies related to the effects of toxic substances on insect metabolism.

Nanozyme-Catalyzed Colorimetric Detection of the Total Antioxidant Capacity in Body Fluids by Paper-Based Microfluidic Chips.

Total antioxidants play a crucial role in human health, and detection of the total antioxidant capacity (TAC) has broad application prospects in fields such as food safety, environmental assessment, and disease diagnosis. However, a long detection time, cumbersome steps, high cost, reliance on professional equipment, and nonportability still remain significant challenges. In this work, an efficient strategy of point-of-care testing (POCT) of the TAC in body fluids by nanozyme-catalyzed colorimetric paper-based microfluidic sensors is proposed. The paper-based microfluidic sensors coupled with a smartphone can reduce testing costs and provide portability. The nanozyme prepared by the solvothermal method presents Michaelis constants of 0.11 and 0.129 mM for H2O2 and TMB, respectively. A method for immobilizing nanozymes and chromogenic agents on a paper-based microfluidic chip is established. Based on smartphone photography and image grayscale extraction, the TAC can be qualitatively detected with a detection limit and linear range of 33.4 and 50-700 μM, respectively. Furthermore, the proposed sensor can realize the one-step quantitative analysis of the TAC in body fluids (blood, saliva, and sweat) within 15 min. The proposed nanozyme-catalyzed colorimetric paper-based microfluidic sensors presented in this study exhibit promising application prospects in the fields of biochemical analysis and POCT.

Structural Complexities in Sodium Ion Conductive Antiperovskite Revealed by Cryogenic Transmission Electron Microscopy.

We use low-dose cryogenic transmission electron microscopy (cryo-TEM) to investigate the atomic-scale structure of antiperovskite Na2NH2BH4 crystals by preserving the room-temperature cubic phase and carefully monitoring the electron dose. Via quantitative analysis of electron beam damage using selected area electron diffraction, we find cryogenic imaging provides 6-fold improvement in beam stability for this solid electrolyte. Cryo-TEM images obtained from flat crystals revealed the presence of a new, long-range-ordered supercell with a cubic phase. The supercell exhibits doubled unit cell dimensions of 9.4 Å × 9.4 Å as compared to the cubic lattice structure revealed by X-ray crystallography of 4.7 Å × 4.7 Å. The comparison between the experimental image and simulated potential map indicates the origin of the supercell is a vacancy ordering of sodium atoms. This work demonstrates the potential of using cryo-TEM imaging to study the atomic-scale structure of air- and electron-beam-sensitive antiperovskite-type solid electrolytes.

Approaches, Goals, and Scientific Integrity in Music Therapy Research with Individuals on the Autism Spectrum: An Integrative Review.

Scientific integrity is fundamental to evidence-based practice (EBP) and essential in music therapy (MT) research and clinical practice. Researchers conducted an integrative review of approaches and interventions employed by music therapists (MTs) with individuals on the autism spectrum in the context of how studies are analyzed by the National Autism Center (NAC) and National Clearinghouse on Autism Evidence and Practice (NCAEP). Researchers identified 880 database records meeting initial search criteria (i.e., autism spectrum disorder, autism, PDD-NOS, MT, and music interventions); 36 studies remained after screening for duplication, topic relevance, and adherence to inclusion criteria. Included studies were published between 1964 and 2021, in English language, in free open-access journals, worldwide; peer reviewed; conducted by MTs; empirical quantitative, qualitative, or mixed-methods design; intervention-based; and presented separate data for participants on the autism spectrum. Content and quantitative analyses identified deficits in scientific integrity and the following gaps in studies reviewed: Motor Skills and Placement (NAC-defined intervention targets), Computer-based and Songwriting and Composition (MT techniques), and Wellness and Bonny Method of Guided Imagery in Music (clinical approaches); no patterns were evident among NAC Interventions with MT techniques and approaches. Analysis of 5-point Scientific Merit Ratings yielded a mean 2.78 rating. A comparison of NAC and NCAEP terminology (i.e., how MT researchers report independent variables) indicated eight titles mention specific non-music interventions, 19 mention MT, 14 include music-based technique descriptors, and two mention both non-music interventions and MT. Researchers offer guidelines regarding identity-inclusive language, scientific integrity, and clarity of EBPs within MT intervention research with individuals on the autism spectrum.

‘We work in the grey around decision making’; how ‘thematic discretion’ can help understand police decision-making in cases of youth image-based sexual abuse

ABSTRACT In this paper, I argue that a new term, ‘thematic discretion’, can help us understand police decision-making in cases of youth image-based sexual abuse (YIBSA). YIBSA can be defined as harmful image-sharing practices amongst young people, inclusive of the non-consensual sharing of private sexual images, upskirting and cyberflashing, alongside other actions. I will be drawing on findings from a doctoral research project investigating YIBSA, which utilised a mixed methods approach, comprising of quantitative analysis of freedom of information requests from 40 police forces in England and Wales, as well as 26 qualitative interviews with police and non-police practitioners, also based within England and Wales. Research findings established that YIBSA is highly complicated, and as a result, police officers utilised discretion at a considerable rate, alongside crafting their own guidelines to direct their decision-making, which is argued to be steeped in sexist and victim-blaming narratives.