Purpose: The aim of this research is to focus on the Quality of work life of Nurses and see its impact on burn outs of Nurses especially during the course of Novel Covid -19 Pandemic in Pakistan. Design/Methodology/Approach: There were 257 nurses in the sample (female 149 and 108 male). Replicability is another factor that is taken into consideration for the credibility of this research to gain confidence through research of the same type that has been conducted. The purposive sampling is utilized to ensure that nurses have the necessary specialised knowledge, as well as the desire and potential to take part in the study and an awareness of the issues. Smart PLS version 4.0 for the structural equation mode has been utilized in the study. Findings: This study's findings corroborate that the quality of work life scales discussed here have an impact on the burnout of Pakistani nurses. These findings show that Pakistani nurses take stress at work positively influence their burnout while control at work and job and career satisfaction influence burnout negatively among them. Moreover, other findings reveal that working conditions and general wellbeing doesn’t affect burnout in Pakistani nurses which may be due to nature of their job or they got use to of these working conditions during Covid-19 by using Covid-19 preventive measures. Implications/Originality/Value: Nurse burnout and its psychological and social consequences are a major problem for all health care systems around the world. If we care about the stress at work due to their extra job responsibilities and give them empowerment at work as well as give them more incentives at jobs they will be more than happy to serve patients.