E-health, by WHO definition, incorporates a range of standards, tools and activities that use electronic means to deliver information, resources and services about health and social care. At the heart of e-health is a vision of improving the quality of health information, strengthening national health systems and ensuring accessible, high-quality health care for all. The use of e-health interventions is effective in improving patient experiences and outcomes. To increase evidence about supportive e-health interventions that include nursing interventions for education to oncology patients under treatment. Subsequently to improve the quality of oncology care by analysing the data in a potential model for e-health application and how efficient health systems are. The review was done according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Reviews and Meta-Analysis guidelines (PRISMA). terms related to cancer, e-health, telemedicine and nursing interventions were searched in the following databases: CINAHL® Plus, Nursing & Allied Health Collection, Cochrane Plus Collection, MEDLINE®, EBSCOhost, Scopus & Joanna Briggs from the last five years. Languages as: English, Spanish and Portuguese, published in last 5 years (January 2017 till February 2022). Seventeen (n = 17) studies were identified. Different designs; quantitative and qualitative methods were included. Reviews and Systematic reviews, prospective cohorts, quasi-experimental and pilot studies were included. The results focus on a technology-based intervention that aims to improve cancer care, health and wellbeing; All the interventions were applied to cancer patients, apply for cancer caregivers (n=1) and young adults with cancer (n=1). E-Health has an enormous potential to improve healthcare cost, effectiveness, and quality of care. Feasibility of internet-based was demonstrated, E-Health use in clinical oncology has had a significant impact on the delivery of cancer care. Nurses in multidisciplinary teams are considerate well placed to support adherence to treatment among cancer patients, E-health helps to manage better care because it can simplify interprofessional team care.