Measures specifically assessing Quality of Life (QOL) post Ventricular Assist Device (VAD) are limited. The QOL with a Ventricular Assist Device (QOLVAD) instrument was recently created to assess QOL after VAD implant. In this pilot study, we evaluated QOL changes using the QOLVAD instrument in VAD patients over time. There were 37 patients who completed consecutive QOLVAD instruments at intervals (1, 3, 6, 9, 12 months and every 6 months following) from 9/2016 to 9/2019. Descriptive data and QOLVAD instruments were analyzed with repeated measures and paired T-Tests for trends in QOL following VAD implantation. The sample (n=37) had 68% males (n=25), mean INTERMACS score 3.19 ±0.97, and 54% with non-ischemic cardiomyopathy (n=20). Mean implant age was 65.84 ±11.65. Repeated measures analysis revealed significant improvements in the Physical Domain scores as well as the Total QOLVAD scores, when looking at 1-3-6 month time points. Table 1 summarizes results and interval means. Follow-up paired T-tests also showed significantly improved QOL in the Physical Domain and the Total QOLVAD scores, from 1 month to 3 month and 1 month to 6 month post implant: Physical t(df=14)=-6.49, p=0.000 and t(df=13)=-5.33, p=0.000, and total QOLVAD t(df=14=-4.66, p=0.000 and t(df=13)=-4.49, p=0.001. The remaining four individual domains (Emotional, Social, Cognitive and Meaning/Spirituality) did not show significant differences (p>0.05). QOL changes are often seen following VAD implant, yet there is a gap of reliable measures for QOL, particularly related to VAD patients. To our knowledge, this is the first report of longitudinal QOL assessment with a VAD-specific measure. These findings provide a preliminary foundation for future evidence-based description of the trajectory of QOL after VAD. Further study is needed with larger sample sizes and multi-center study.