Since reforming and opening to the outside world, Chinese aquiculture has developed very quickly. The total output of aquiculture has been ranking first in the world over ten years, but it still has many problems. In this article, many problems are listed about Chinese aquiculture, which has seriously influenced the quality of aquatic products and destroyed the whole aquiculture ecological environment, so it is imperative under the situation to implement healthy culture. At the same time, the actuality of Chinese healthy culture is analyzed, and healthy culture has been developed in freshwater and sea water. Healthy culture comes down to many aspects, and it is a very important part to reasonably use fishery medicines. The using of fishery medicines should start from many aspects including medicine materials, cause of disease, environment, aquatic animals, and human health, and only to use medicines intentionally and effectively can achieve the effect of preventing and treating diseases. The green fishery medicine is one most effective development direction at present to use medicines reasonably. Green fishery medicines include fishery vaccine, Chinese herbal medicine preparation, animalcule preparation, and biologic fishery medicines.