In Italy, the interest in the industrial areas dates back to 1970, when industry began to be considered as identity and memory of the population, until 1990, when industrial constructions became cultural and historical goods. This interest was also justified by the necessity to recover these often-abandoned sites through structural and seismic interventions. For this purpose, the cataloguing of the different industrial buildings in Italy was made by the Italian Consortium ReLUIS “Network of Seismic Engineering University Laboratories”, through the “Cartis Long Spans” form, to obtain indications on the seismic vulnerability of this built heritage. In the current paper, the seismic analysis and the combined seismic–energy retrofit of a former reinforced concrete tobacco factory in Cervinara, within the district of Avellino (Italy), were carried out. This work proposes a seismic retrofit intervention of the examined structure, erected at the end of the 1960s, based on the use of steel exoskeletons. The proposed intervention can be seen as a novel strategy for requalification of industrial buildings, as well as for regeneration and restoration of the value of industrial areas. It was shown that these devices allow a considerable increase of the seismic safety indices, which attain values significantly greater than 1, to reach the building retrofitting. Subsequently, a photovoltaic plant using high-efficiency panels is proposed to provide the entire hub’s energy requirement. It was found that the annual production/square meterage of the building is between 20% and 60% lower than that of school and office buildings. As a whole, the analysis results demonstrated that exoskeletons are an effective intervention to improve the seismic features of the studied industrial building without neglecting architectural quality, sustainability, and environmental issues.