Improve Image Quality Research Articles

Dose calculation accuracy of a new high-performance ring-gantry CBCT imaging system for prostate and lung cancer patients

Background and purposeThe recently introduced high-performance CBCT imaging system called HyperSight offers improved Hounsfield units (HU) accuracy, a larger CBCT field-of-view and improved image quality compared to conventional ring gantry CBCT, possibly enabling treatment planning on CBCT imaging directly. In this study, we evaluated whether the dose calculation accuracy on HyperSight CBCT was sufficient for treatment planning in prostate and lung cancer patients. Materials and methodsHyperSight CBCT was compared to planning CT in terms of HU-to-mass density (MD) calibration curves. For twenty prostate patients and twenty lung patients, differences in DVH parameters, and 3D global gamma between dose distributions calculated on planning CT and free breathing HyperSight CBCT were evaluated. For this purpose, HyperSight CBCT acquired at the first fraction was rigidly registered to the pCT, delineations from the CT were propagated and the dose was recalculated on the HyperSight CBCT. ResultsFor each insert of the HU-to-MD calibration phantom, the HU values of HyperSight CBCT and pCT agreed within 35 HU. For prostate maximum deviations in PTV Dmean, V95% and V107% were 1.8 %, −1.1 % and < 0.1 % respectively. For lung PTV V95% was generally lower (median −1.1 %) and PTV V107% was generally higher (median 1.1 %) on HyperSight CBCT due to breathing motion artifacts. The average (±SD) 2 %/2mm gamma pass rate was 98.7 %±1.2 % for prostate cancer patients and 96.2 %±2.1 % for lung cancer patients. ConclusionHyperSight CBCT enabled accurate dose calculation for prostate cancer patients, without implementation of a specific HyperSight CBCT-to-MD curve. For lung cancer patients, breathing motion hampered accurate dose calculations.

Scan-Specific Unsupervised Highly Accelerated Non-Cartesian CEST Imaging Using Implicit Neural Representation and Explicit Sparse Prior.

Chemical exchange saturation transfer (CEST) is a promising magnetic resonance imaging (MRI) technique. CEST imaging usually requires a long scan time, and reducing acquisition time is highly desirable for clinical applications. A novel scan-specific unsupervised deep learning algorithm is proposed to accelerate steady-state pulsed CEST imaging with golden-angle stack-of-stars trajectory using hybrid-feature hash encoding implicit neural representation. Additionally, imaging quality is further improved by using the explicit prior knowledge of low rank and weighted joint sparsity in the spatial and Z-spectral domain of CEST data. In the retrospective acceleration experiment, the proposed method outperforms other state-of-the-art algorithms (TDDIP, LRTES, kt-SLR, NeRP, CRNN, and PBCS) for the in vivo human brain dataset under various acceleration rates. In the prospective acceleration experiment, the proposed algorithm can still obtain results close to the fully-sampled images. The hybrid-feature hash encoding implicit neural representation combined with explicit sparse prior (INRESP) can efficiently accelerate CEST imaging. The proposed algorithm achieves reduced error and improved image quality compared to several state-of-the-art algorithms at relatively high acceleration factors. The superior performance and the training database-free characteristic make the proposed algorithm promising for accelerating CEST imaging in various applications.

Application of deep learning reconstruction in abdominal magnetic resonance cholangiopancreatography for image quality improvement and acquisition time reduction

PurposeTo compare deep learning (DL)-based and conventional reconstruction through subjective and objective analysis and ascertain whether DL-based reconstruction improves the quality and acquisition speed of clinical abdominal magnetic resonance imaging (MRI). MethodsThe 124 patients who underwent abdominal MRI between January and July 2021 were retrospectively studied. For each patient, two-dimensional axial T2-weighted single-shot fast spin-echo MRI images with or without fat saturation were reconstructed using DL-based and conventional methods. The subjective image quality scores and objective metrics, including signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) of the images were analysed. An explorative analysis was performed to compare 20 patients’ MRI images with site routine settings, high-resolution settings and high-speed settings. Paired t tests and Wilcoxon signed-rank tests were used for subjective and objective comparisons. ResultsA total of 144 patients were evaluated (mean age, 62.2 ± 14.1 years; 83 men). The MRI images reconstructed using DL-based methods had higher SNRs and CNRs than did those reconstructed using conventional methods (all p < 0.01). The subjective scores of the images reconstructed using DL-based methods were higher than those of the images reconstructed using conventional methods (p < 0.01), with significantly lower variation (p < 0.01). Exploratory analysis revealed that the DL-based reconstructions with thin slice thickness and higher temporal resolution had the highest image quality and were associated with the shortest scan times. ConclusionsDL-based reconstruction methods can be used to improve the quality with higher stability and accelerate the acquisition of abdominal MRI.

CT image reconstruction: integrating iterative methods with Ml-EM algorithm and deep learning models

Computed Tomography (CT) imaging faces limitations, including low spatial resolution and noise, particularly in low-radiation-dose imaging. To address these challenges, researchers are exploring CT image reconstruction from sinogram data. Sinograms represent X-ray absorption throughout the body, and sophisticated image reconstruction methods, including machine learning algorithms and generative adversarial networks (GANs), can improve precision and resolution without increasing patient radiation exposure. This study proposes an iterative reconstruction approach that combines filters from deep learning models (Convolutional Neural Networks and UNet) with the Maximum Likelihood Expectation Maximization (ML-EM) algorithm and the Enhanced Super-Resolution Generative Adversarial Networks (ESRGAN) model. Our method aims to enhance image quality and reconstruction speed. Experimental results show significant improvements in image quality and resolution, with the proposed method (DL-MLEM-IR-UNET-ESRGAN) achieving an average SSIM of 0.9980 and PSNR of 53.2119, outperforming other methods. Additionally, our method reduces reconstruction time, with an average runtime of 131 seconds.

Modifying the Silt Lamp by Using a White Laser in Place of the Halogen Light

This paper explores the modification of the slit lamp, a vital ophthalmic instrument, by replacing the traditional halogen light source with a white laser. This modification aims to enhance the diagnostic capabilities and efficiency of the slit lamp. White laser technology offers superior brightness, intensity, and color accuracy, which improves the visibility and differentiation of ocular tissues. Additionally, white lasers are more energy-efficient, provide consistent light output, and require less maintenance. The redesign process includes adjustments to the optical system, incorporating specialized filters and lenses, and ensuring proper thermal management. The integration of a high-resolution digital camera system with white laser illumination further improves image quality and diagnostic precision. The study outlines the benefits, potential challenges, and implementation steps, concluding that the use of white lasers in slit lamps can significantly enhance the effectiveness of ocular diagnostics, benefiting both ophthalmologists and patients.

Advanced Filtering and Enhancement Techniques for Diabetic Retinopathy Image Analysis

Diabetic retinopathy is a leading cause of visual impairment and blindness in diabetes sufferers. Early detection is crucial to prevent severe outcomes. This study presents an image processing method for retinal images to aid early detection. The method involves four steps: image enlargement, preprocessing, enhancement, and convolution. First, an algorithm enlarges the retinal image to increase resolution and reveal finer details. Preprocessing uses a min-max filtering algorithm to reduce noise and improve image quality. Next, specific pixel range enhancement techniques further refine the image and highlight relevant features. Finally, convolution with customized kernels detects and emphasizes areas indicating diabetic retinopathy, such as aneurysms and hemorrhages. Experimental results show improvement in image clarity and detail, enabling more accurate detection of diabetic retinopathy features. The correlation results are as follows: Filtering (0.35275, 0.20157, 0.4345), Enhancement (0.3214, 0.15823 0.34674), and Convolution (0.33542, 0.15758, 0.36826). The proposed algorithm enhances early detection and diagnosis by improving retinal image quality. Future work can optimize the algorithm and validate results with larger datasets, aiming to refine the determination of areas or pixel values relevant to diabetic retinopathy.

Image quality improvement in single plane-wave imaging using deep learning

In ultrasound image diagnosis, single plane-wave imaging (SPWI), which can acquire ultrasound images at more than 1000 fps, has been used to observe detailed tissue and evaluate blood flow. SPWI achieves high temporal resolution by sacrificing the spatial resolution and contrast of ultrasound images. To improve spatial resolution and contrast in SPWI, coherent plane-wave compounding (CPWC) is used to obtain high-quality ultrasound images, i.e., compound images, by coherent addition of radio frequency (RF) signals acquired by transmitting plane waves in different directions. Although CPWC produces high-quality ultrasound images, their temporal resolution is lower than that of SPWI. To address this problem, some methods have been proposed to reconstruct a ultrasound image comparable to a compound image from RF signals obtained by transmitting a small number of plane waves in different directions. These methods do not fully consider the properties of RF signals, resulting in lower image quality compared to a compound image. In this paper, we propose methods to reconstruct high-quality ultrasound images in SPWI by considering the characteristics of RF signal of a single plane wave to obtain ultrasound images with image quality comparable to CPWC. The proposed methods employ encoder–decoder models of 1D U-Net, 2D U-Net, and their combination to generate the high-quality ultrasound images by minimizing the loss that considers the point spread effect of plane waves and frequency spectrum of RF signals in training. We also create a public large-scale SPWI/CPWC dataset for developing and evaluating deep-learning methods. Through a set of experiments using the public dataset and our dataset, we demonstrate that the proposed methods can reconstruct higher-quality ultrasound images from RF signals in SPWI than conventional method.

Machine Learning in Online Car Retail: Enhancing User Experience and Conversion Rates

This article examines the transformative impact of machine learning (ML) applications on the online car buying experience. We explore three key areas where ML significantly enhances user engagement and drives conversion rates: image processing, personalized recommendations, and data-driven insights. Advanced ML models are shown to improve image quality, standardize vehicle presentations, and facilitate easier comparisons. Personalization algorithms, leveraging vector embeddings and reinforced feedback loops, tailor the browsing experience to individual preferences. Additionally, ML-driven insights provide users with valuable information on pricing trends and deal rankings. Our analysis reveals that these applications not only streamline the car buying process but also address critical challenges in the digital automotive retail space. The article highlights the potential for increased customer satisfaction, improved inventory management, and competitive advantages for early adopters. While acknowledging implementation challenges, including data privacy concerns and integration complexities, we conclude that ML technologies are poised to revolutionize the online car buying landscape, setting new standards for user experience and operational efficiency in automotive e-commerce

Information hiding using approximate POSIT representation

AbstractPOSIT is a numerical system consists of sign, regime, exponential, and fraction bits to overcome some limitations of the IEEE‐754 floating point (FP) representation. This work proposes a technique to hide critical information in the least significant bits (LSBs) of the POSIT FP representation by exploiting approximate computing (AC). The proposed technique, called information hiding using POSIT and LSB (IHUPL), explores the opportunities offered by both the POSIT representation and the AC to hide information with a minimum loss in accuracy and other performance metrics. IHUPL offers two options for hiding information: either by embedding one digit of each character into each pixel or by embedding all the digits of the character at the same time into each pixel of the alpha‐red, green, blue, or black/white image. Experimental results are evaluated for benchmark images and showed that IHUPL enhanced the accuracy of embedding data into LSB of POSIT FP by an average of 5%, the image quality improvement rates of IHUPL are 19% and 16% for options 1 and 2, respectively. Besides the encoding method using IHUPL, the paper outlines an extraction decoding technique that saves the original replacement bits in a key‐image to recover the hidden security message.

Bilateral fusion low‐light image enhancement with implicit information constraints

AbstractResearch on low‐light image enhancement focuses on improving image quality in dim conditions. Recently, deep learning has driven significant advancements, with many studies using neural networks to enhance low‐light images. However, most focus on complex network designs to increase nonlinearity, often neglecting the implicit information from local image transformations. This paper introduces an improved U‐net‐based method for low‐light enhancement, retaining the original encoding network and adding branch links in the decoding network. The method uses attention feature fusion to handle image noise and gradients separately, adjusting brightness through a gradient‐adaptive transform. This approach optimizes performance using loss functions like peak signal‐to‐noise ratio and colour consistency. Unlike previous methods, the approach emphasizes extracting implicit information from image gradients, achieving enhancement that aligns with the original brightness distribution. The result is enhanced images with high detail similarity to the original, achieved through end‐to‐end inference in experiments.

Radar Target Radar Cross-Section Measurement Based on Enhanced Imaging and Scattering Center Extraction.

Accurate measurement of a Radar Cross-Section (RCS) is a critical technical challenge in assessing the stealth performance and scattering characteristics of radar targets. Traditional RCS measurement methods are limited by high costs, sensitivity to environmental conditions, and difficulties in distinguishing local scattering features of targets. To address these challenges, this paper proposes a novel RCS measurement method based on enhanced imaging and scattering center extraction. This method integrates sub-aperture imaging with image fusion techniques to improve imaging quality and enhance the detail of target scattering characteristics. Additionally, an improved sequence CLEAN algorithm is employed to effectively suppress sidelobe effects and ensure the accuracy of scattering center extraction. Experimental results demonstrate that this method achieves higher precision in RCS measurement of complex targets and is particularly effective in environments with strong interference, where it successfully separates the scattering contributions of the target from those of the interference sources. This method offers a new technological approach for precise RCS measurement of radar stealth targets in the future.

Optimization of Sparse Camera Array Arrangement using Grid-based Method

—This study explores the application of multi-camera array technology in super-resolution (SR) imaging system. We propose an innovative method based on grid representation to optimize camera arrangements using sparse Gaussian processes and variational inference. This approach significantly enhances the image reconstruction quality of sparse camera arrays. Unlike conventional techniques that provide only qualitative conclusions, our grid-based method precisely optimizes camera positions and effectively simulates the impact of assembly errors. The optimized camera arrangement substantially improves the SR reconstruction quality of sparse array imaging systems, reducing contour jaggedness and high-frequency aliasing. Extensive simulations and experimental validations confirm the robustness and practical applicability of our method. The results demonstrate that the optimized camera arrangements can achieve high-resolution imaging with enhanced robustness against assembly errors, indicating their potential for various applications such as biological microscopy, remote sensing, and smartphone photography. This work presents a new and effective strategy for designing sparse camera array imaging systems, offering significant improvements in both image quality and system reliability.

Advanced mathematical modeling for preciseestimation of CT energy spectrum using a calibration phantom

PurposeThis research aims to develop an advanced mathematical model using a CT calibration phantom to accurately estimate the CT energy spectrum in clinical settings, enhancing imaging quality and patient dose management. MethodsData were collected from a CT scanner using a CT calibration phantom at various energy levels (80, 100, 120, and 135 kVp). The data was optimized to refine the energy spectrum model, followed by cross-validation with Monte Carlo simulations. ResultsThe developed model demonstrated high precision in estimating the CT energy spectrum at all tested energy levels, with R-squared values above 0.9738 and an R-squared value of 0.9829 at 100 kVp. The model also showed low Normalized Root Mean Square Deviation (NRMSD) ranging from 0.6698 % to 1.8745 %. The Mean Energy Difference (ΔE) between the estimated and simulated spectrum consistently remained under 0.01 keV. These results were comparable to recent studies, which reported higher NRMSD and ΔE. ConclusionsThis study presents a significantly improved model for estimating the CT energy spectrum, offering greater accuracy than existing models. Its strengths include high precision and the use of standard equipment and algorithmic values. While the current use of 13 plugs is adequate, incorporating plugs with varied densities could enhance accuracy. This model has potential for improving imaging quality and optimizing patient dosing in clinical applications. Future trends may include extending energy spectrum estimation to megavoltage domains and integrating technologies like EPID and MVCT for better dose distribution prediction in high-energy photon beam therapy.

Compressed sensing reconstruction for high-SNR, rapid dissolved 129Xe gas exchange MRI.

Three-dimensional hyperpolarized 129Xe gas exchange imaging suffers from low SNR and long breath-holds, which could be improved using compressed sensing (CS). The purpose of this work was to assess whether gas exchange ratio maps are quantitatively preserved in CS-accelerated dissolved-phase 129Xe imaging and to investigate the feasibility of CS-dissolved 129Xe imaging with reduced-cost natural abundance (NA) xenon. 129Xe gas exchange imaging was performed at 1.5 T with a multi-echo spectroscopic imaging sequence. A CS reconstruction with an acceleration factor of 2 was compared retrospectively with conventional gridding reconstruction in a cohort of 16 healthy volunteers, 5 chronic obstructive pulmonary disease patients, and 23 patients who were hospitalized following COVID-19 infection. Metrics of comparison included normalized mean absolute error, mean gas exchange ratio, and red blood cell (RBC) image SNR. Dissolved 129Xe CS imaging with NA xenon was assessed in 4 healthy volunteers. CS reconstruction enabled acquisition time to be halved, and it reduced background noise. Median RBC SNR increased from 6 (2-18) to 11 (2-100) with CS, and there was strong agreement between CS and gridding mean ratio map values (R2 = 0.99). Image fidelity was maintained for gridding RBC SNR > 5, but below this, normalized mean absolute error increased nonlinearly with decreasing SNR. CS increased the mean SNR of NA 129Xe images 3-fold. CS reconstruction of dissolved 129Xe imaging improved image quality with decreased scan time, while preserving key gas exchange metrics. This will benefit patients with breathlessness and/or low gas transfer and shows promise for NA-dissolved 129Xe imaging.

Recent Advances and Future Perspectives in Radiolabeled Antibody Fragments for Breast Cancer Molecular Imaging

Breast Cancer (BC) is the leading cause of cancer-related deaths in women and the most common cancer worldwide. It is classified based on its anatomical origin, the presence of Human Epidermal Growth Factor Receptor 2 (HER-2), and the presence of Estrogen Receptor (ER) and/or Progesterone Receptor (PR). Around 20% of breast cancers are HER-2 positive. While biopsy-based diagnoses are valuable in clinical settings, they have limitations in terms of sampling and interpretation. However, laboratory tests such as Immunohistochemistry (IHC) or Fluorescence In Situ Hybridization (FISH) are also limited, including being time-consuming, expensive, and requiring specialized equipment. Ongoing research and technological advancements aim to address the challenges associated with biopsy-based diagnoses and laboratory tests to develop more accurate and efficient methods for assessing HER-2 status. To this end, various radioactively labeled proteins and small compounds, such as single-chain variable Fragments (scFv), F(ab')2, affibody, and nanobody, have been developed to target HER-2 using molecular array techniques. These smaller targeted compounds offer improved image quality, shorter circulating half-life, and reduced immunogenicity compared to their larger counterparts. This is due to their better biodistribution, clearance, and stability. This study investigates the current understanding and ongoing efforts in utilizing antibody fragments for molecular imaging. The specific objectives were to evaluate the advantages of antibody fragments over full-length antibodies regarding biodistribution, clearance, and stability. Additionally, this study aims to assess the current knowledge and ongoing research in utilizing antibody fragments for molecular imaging.

Application value of individualized tube voltage, contrast injection, and adaptive statistical iterative reconstruction V algorithm based on body mass index in renal computed tomography angiography for radiation and iodinated contrast dose reduction.

To explore the application value of body mass index (BMI)-based kilovoltage peak (kVp) selection and contrast injection protocol combined with different adaptive statistical iterative reconstruction V (ASIR-V) strengths in renal computed tomography angiography (CTA) in reducing radiation and contrast medium (CM) doses. One-hundred renal CTA patients were prospectively enrolled and were divided into individualized kVp group (group A, n = 50) and conventional 100kVp group (group B, n = 50), both with automatic tube current modulation and CM of Iohexol at 350mgI/mL concentration. Group A: 70kVp, noise index (NI) of 18 and CM dose rate of 17mgI/kg/s for 10 s for BMI <25kg/m2 patients; 80kVp, NI = 17, and CM dose rate of 19mgI/kg/s for 10 s for 25 kg/m2≤BMI≤30kg/m2 patients. Group B: 100kVp, 50 mL of CM at the flow rate of 4.5 mL/s. The objective image quality, effective radiation dose, CM dose, injection rate, and image quality were compared between the 2 groups. There was no significant difference in patient characteristics between the 2 groups (P > .05). Compared to group B, group A significantly reduced effective radiation dose by 28.4%, CM dose by 27.2%, and injection rate by 22.7% (all P < .001). The 2 groups had similar SD values in erector spine (P > .05). Group A had significantly higher CT values, SNR, and CNR values of the renal arteries than group B (all P < .001). The 2 radiologists had excellent agreement (Kappa value > 0.8) in the subjective scores of renal CTA images and showed no statistically significant difference between the 2 groups (4.57 ± 0.42 vs 4.41 ± 0.49) (P > .05). BMI-based scan and reconstruction protocol in renal CTA significantly reduces radiation and contrast doses while maintaining diagnostic image quality. (i) BMI-based individualized tube voltage selection and contrast injection protocol in renal CTA reduces both radiation and contrast doses over conventional protocol. (ii) The combination of lower kVp and higher weight ASIR-V maybe used to improve image quality in terms of contrast enhancement and image noise under lower radiation and contrast dose conditions. (iii) Renal CTA of normal size (BMI ≤ 30kg/m2) patients acquired at low radiation dosage and low iodine contrast dose through the combination of low tube voltage and ASIR-V algorithm achieves excellent diagnostic image quality with a good inter-rater agreement.

Imaging in Renal Cell Carcinoma Detection.

Imaging in renal cell carcinoma (RCC) is a constantly evolving landscape. The incidence of RCC has been rising over the years with the improvement in image quality and sensitivity in imaging modalities resulting in "incidentalomas" being detected. We aim to explore the latest advances in imaging for RCC. A literature search was conducted using Medline and Google Scholar, up to May 2024. For each subsection of the manuscript, a separate search was performed using a combination of the following key terms "renal cell carcinoma", "renal mass", "ultrasound", "computed tomography", "magnetic resonance imaging", "18F-Fluorodeoxyglucose PET/CT", "prostate-specific membrane antigen PET/CT", "technetium-99m sestamibi SPECT/CT", "carbonic anhydrase IX", "girentuximab", and "radiomics". Studies that were not in English were excluded. The reference lists of selected manuscripts were checked manually for eligible articles. The main imaging modalities for RCC currently are ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI). Contrast-enhanced US (CEUS) has emerged as an alternative to CT or MRI for the characterisation of renal masses. Furthermore, there has been significant research in molecular imaging in recent years, including FDG PET, PSMA PET/CT, 99mTc-Sestamibi, and anti-carbonic anhydrase IX monoclonal antibodies/peptides. Radiomics and the use of AI in radiology is a growing area of interest. There will be significant change in the field of imaging in RCC as molecular imaging becomes increasingly popular, which reflects a shift in management to a more conservative approach, especially for small renal masses (SRMs). There is the hope that the improvement in imaging will result in less unnecessary invasive surgeries or biopsies being performed for benign or indolent renal lesions.

Design of a Novel Microlens Array and Imaging System for Light Fields.

Light field cameras are unsuitable for further acquisition of high-quality images due to their small depth of field, insufficient spatial resolution, and poor imaging quality. To address these issues, we proposed a novel four-focal-square microlens and light field system. A square aspheric microlens array with four orthogonal focal lengths was designed, in which the aperture of a single lens was 100 μm. The square arrangement improves pixel utilization, the four focal lengths increase the depth of field, and the aspheric improves image quality. The simulations demonstrate pixel utilization rates exceeding 90%, depth-of-field ranges 6.57 times that of a single focal length, and image quality is significantly improved. We have provided a potential solution for improving the depth of field and image quality of the light field imaging system.

Improvement in Image Quality of Low-Dose CT of Canines with Generative Adversarial Network of Anti-Aliasing Generator and Multi-Scale Discriminator.

Computed tomography (CT) imaging is vital for diagnosing and monitoring diseases in both humans and animals, yet radiation exposure remains a significant concern, especially in animal imaging. Low-dose CT (LDCT) minimizes radiation exposure but often compromises image quality due to a reduced signal-to-noise ratio (SNR). Recent advancements in deep learning, particularly with CycleGAN, offer promising solutions for denoising LDCT images, though challenges in preserving anatomical detail and image sharpness persist. This study introduces a novel framework tailored for animal LDCT imaging, integrating deep learning techniques within the CycleGAN architecture. Key components include BlurPool for mitigating high-resolution image distortion, PixelShuffle for enhancing expressiveness, hierarchical feature synthesis (HFS) networks for feature retention, and spatial channel squeeze excitation (scSE) blocks for contrast reproduction. Additionally, a multi-scale discriminator enhances detail assessment, supporting effective adversarial learning. Rigorous experimentation on veterinary CT images demonstrates our framework's superiority over traditional denoising methods, achieving significant improvements in noise reduction, contrast enhancement, and anatomical structure preservation. Extensive evaluations show that our method achieves a precision of 0.93 and a recall of 0.94. This validates our approach's efficacy, highlighting its potential to enhance diagnostic accuracy in veterinary imaging. We confirm the scSE method's critical role in optimizing performance, and robustness to input variations underscores its practical utility.

Simultaneous iodine and barium imaging with photon-counting CT

Photon-counting computed tomography (PCCT) could potentially offer significant improvements in image quality over conventional CT. This study leverages PCCT technology to achieve simultaneous multi-contrast imaging of barium (Z=56) and iodine (Z=53), addressing the limitations of conventional CT in differentiating materials with similar atomic numbers. Using a bench-top PCCT system with a cadmium zinc telluride (CZT) detector, experiments were conducted with various phantom setups and 1-5\% contrast agent concentrations and in a biological sample. Energy thresholds were adjusted to the K-edge absorption energies of barium (37.4 keV) and iodine (33.2 keV) to capture multi-energy CT images. K-edge decomposition was performed with K-edge subtraction and principal component analysis (PCA) techniques, demonstrating clear differentiation and accurate quantification of contrast agents in phantom combinations and the biological sample. The PCCT system successfully differentiated and quantified barium and iodine, with high correlations ($R^2 \approx 1$) between true and reconstructed concentrations. PCA outperformed K-edge subtraction by providing a superior capability to differentiate barium and iodine, particularly when calcium was present in the scanned object. These findings highlight the potential of PCCT for reliable, detailed imaging in clinical and research applications, particularly for contrast agents with close atomic numbers.