Recently, various high quality factor photonic crystal microcavities have been demonstrated theoretically and experimentally with only one-dimensional periodicity. However, in most cases high-index materials such as silicon were chosen for easily achievable large photonic bandgap and elaborate refractive index modulation or taper structure is required for reducing radiation loss. Here, we present a design of high-Q microcavities in one-dimensional multilayer polystyrene photonic crystal slab structures with a low-index contrast of 1.59:1. Microcavities are introduced by simply decreasing the thickness of layers at the center region to form a double-heterostructure. A resonant mode with a quality factor up to 20 000 is obtained and found to originate from the modal gap confinement by comparing with a Fabry–Perot cavity. The dependence of the maximal quality factor on the cavity length further reveals that the small group velocity of light within the heterostructure cavity contributes significantly to the high-Q. In terms of the high quality factor, ease of fabrication, and large Kerr nonlinearity of polystyrene, our double-heterostructure microcavities will find potential application in realizing all-optical modulation devices.