Background Internal quality control IQC samples are used to monitor and evaluate the day to day analytical performance of parameters in a laboratory. While IQC is more useful in evaluating analytical precision External quality assessment EQA can evaluate both precision and agreement with peers. With the introduction of newer software IQC results can also be compared with peers to give an estimate of agreement in values.Aims This study was undertaken to evaluate the agreement between the peer comparison scores obtained from EQA and IQC. The Z-score from EQA was compared with the Standard Deviation Index SDI from IQC peer comparison data using two common chemistry analytes glucose and urea on Siemenrsquos Dimension.Methodology The monthly IQC Data from Unity Real Time URT software and the monthly EQA report of glucose and urea over a period one year was used for obtaining the two scores. The monthly Z score from EQA reports was compared with the corresponding monthly SDI calculated from IQC peer comparison data for the two parameters. Glucose and urea were analyzed on Siemenrsquos Dimension ExL fully automated Chemistry analyzer.Result Our study showed similar trends in the performance of the parameters in the peer comparison scores between IQC and EQA. However there was no statistically significant agreement between the two absolute scores.Conclusion This study shows that although the peer comparison scores in performance of an analyte can be obtained from both IQC and EQA it may not be appropriate to extrapolate the analyte performance observed in IQC to EQA in terms of absolute value in the scores.