Quality Of Life Research Articles

An observational comparative study to evaluate the efficacy and safety of pregabalin and gabapentin in neuropathic pain- at a Teritiary Care Centre

Background: Millions of people around the world suffer from Neuropathic pain (Nep), a prevalent and debilitating condition. Treatment for NeP typically includes anticonvulsants, antidepressants, opioids, topical medications, and local anesthetics. Although Pregabalin and Gabapentin are commonly used for this purpose, there is a lack of conclusive evidence supporting their efficacy. NeP significantly diminishes patients' quality of life. This study aims to evaluate the safety and effectiveness of Gabapentin and Pregabalin in treating patients with NeP. Methods: Among a total of 100 patients 50 patients (Group A) were given Gabapentin and 50 Patients (Group B) were given Pregabalin. The efficacy of drug was measured on the basis of decrease in NeP based on Douleur Neuropathique 4 questions (DN4) pain scale measured at baseline, after one month and after two months. Adverse drug reaction (ADR) reported by the patient or observed by the clinician during the study was reported using ADR reporting form. Result: The mean reduction of the neuropathic pain score in Group A from baseline to 2 months was 2.15, while in Group B it was 3.49. Hence, pregabalin showed comparable pain reduction to gabapentin at the end of the 2-months study. Conclusion: Pregabalin 100 mg once daily brought better improvement of symptoms and signs than Gabapentin 300 mg administered once daily. The study found that Pregabalin is a better drug for the treatment of neuropathic pain than Gabapentin. Gabapentin had fewer adverse effects than Pregabalin.

Health-related quality of life after liver transplantation

Background: Mongolian citizens in need of liver transplant treatment have been receiving the treatment abroad since 2004, and in Mongolia since 2011. As the number of years of life after liver transplantation increases, it is important to better understand the factors that influence patient’s quality of life during those years, and what can be done to modify them. (1) Quality of life reflects how the interaction between socio-economic and environmental factors influences social and human development. (2) Studies on work capacity have shown that 6% of people after liver transplantation are classified as unable to work based on functional and international disability assessments, (3) while 23-61% are fully employed after liver transplantation. (4)(5) There is a lack of research examining the physical, psychological, and social well-being of patients after liver transplant treatment in Mongolia. Methods: Data were collected from 144 liver transplant cases using descriptive research design and questionnaire method. The study used the SF-36 Health Assessment Questionnaire, which was grouped into 8 groups and the scores were averaged according to the scale. The results of the study were analyzed using SPSS 25.0 software using Pearson’s Chi-square test for differences between groups. Results: Of the total 144 cases included in the study, 81 (56.3%), were male and 63 (43.8%) were female. By age group, 120 (83.3%) are between the ages of 19-60, or working age, and 24 (16.7%) are over 60. Employment after liver transplantation was 41 (28.5%) full-time, 19 (13.2%) part-time, 84 (58.3%) unemployed or there was no statistically significant difference between groups (P=0.024), of which 62 (43%) were willing to work, 17 (12%) were unwilling to work, and 65 (45%) were unknown (0.173) with no statistically significant difference. When assessing health-related quality of life, physical activity was 65.7±27.1, health-related limitations 38.5±40.1, psychological limitations 41.9±43.0, pain 65.5±27.2, psychological average 71.7±19.2, physical energy average 57.8±21.2, moderate, social participation average 68.1±20.6, and health change 85±22.2, indicating that citizens who underwent liver transplant treatment had good health-related quality of life and health change indicators. Conclusion: People who have undergone liver transplant treatment have good health-related quality of life and health-related changes.

Impact of sense of coherence on oral hygiene, dental caries and periodontal status of young adults in Chennai, Tamil Nadu

Background: Sense of Coherence (SOC) is a logical factor that enables people to cope with stressors and successfully improve health. Oral health has an impact on general health and Quality of Life. This study was undertaken with the aim to assess the impact of SOC with Oral Hygiene, dental caries and periodontal status among young adults in Chennai, Tamil Nadu. Materials and methods: The study was conducted among 500 young adults of age group 19 to 23 years selected using cluster random sampling. SOC data were collected using 13 item standardized versions of SOC scale proposed by Antonovsky. Oral hygiene status was assessed using Oral Hygiene Index- Simplified (OHI-S) by John C Greene and Jack R Vermillion, Dental caries was assessed using WHO criteria Decayed Missing Filled Treatment (DMFT) index and Periodontal status was estimated using the Community Periodontal Index (CPI). Analysis was done using Median test and Pearson correlation to compare SOC scores with dental parameters. Level of significance was set at 0.05. Results: SOC scores ranged from a minimum of 22 to a maximum of 81. The mean SOC score is 52.8 ± 7.6. There was no significant association between SOC and OHI(S), and mean DMFT. CPI and LOA were found to be significantly associated with SOC. The correlation test confirms that there is a significant weak correlation (R= -0.094; p<0.05) between CPI and SOC, i.e., as SOC score increases, CPI score decreases. However, Correlation value is not significant in LOA vs SOC. Conclusion: Although there was a significant relation only between SOC and CPI, the concept can be used to modify the oral health care behaviours to improve their quality of life.

Augmenting Performance Management: Essential in Promoting Enhancement of Career Prospects

Within personal and professional lives of the individuals, they are required to carry out number of job duties and responsibilities. Furthermore, they are required to augment information in terms of different types of methodologies and procedures. These are the ways of carrying out all types of job duties and responsibilities in a well-ordered and satisfactory manner. As a consequence, one will render an important contribution in managing their performance. In this manner, one will achieve desired goals and objectives. Furthermore, individuals in leadership positions within professional settings and family members will be pleased. Hence, throughout the lives of the individuals, belonging to all occupations and fields need to augment their information in terms of different types of skills and abilities. Furthermore, one needs to reinforce the traits of morality, ethics, diligence and conscientiousness. These need to be put into operation in a well-ordered and satisfactory manner in order to enhance one’s performance. Furthermore, one will achieve professional goals and bring about improvements in one’s overall quality of lives. Hence, it is of utmost significance to acknowledge and reinforce the strategies in all occupations and fields, which would be facilitating in enhancement of performance. Therefore, augmenting performance management is essential in promoting enhancement of career prospects. The main concepts that are taken into account in this research paper are, understanding the meaning and significance of performance management, measures to be put into operation in augmenting performance management and advantages of augmenting performance management.

Recognizing the Significance of Socialization: Vital in Leading to Progression of Individuals

The main objective of this research paper is to acquire an efficient understanding of the meaning and significance of socialization. This is regarded as one of the indispensable aspects in bringing about improvements in one’s overall standards of living. From the stage of early childhood, throughout the lives of the individuals, they need to recognize the importance of socialization. This needs to be put into operation with family and community members. One needs to make efforts in order to reinforce socialization. Furthermore, within all types of professional settings, i.e. educational institutions of all levels and in various types of employment settings, honing socialization is regarded as vital in leading to up-gradation of overall personality traits. In addition, one will bring about improvements in their overall quality of lives. Hence, it is of utmost significance for individuals throughout their lives to be well-equipped in terms of strategies of forming an effective social circle. As a consequence of putting into operation all these strategies, one will contribute in an effective manner in reinforcing socialization within and outside the homes. The individuals will render an important contribution in bringing about improvements in their overall personality traits and standards of living, when they are rendering in reinforcing socialization. Hence, it is considered to be worthwhile and favorable in leading to progression of individuals. Therefore, it is well-understood, recognizing the significance of socialization is vital in leading to progression of individuals. The main concepts that are taken into account in this research paper are, understanding the meaning and significance of socialization, measures to be put into operation in reinforcing socialization and advantages of recognizing the significance of socialization.

Clinical features of pediatric spinal tuberculosis at tertiary general hospital

Spinal Tuberculosis is a secondary tuberculosis due to hematogenous spread from the primary infection site (lungs) caused by the bacteria Mycobacterium tuberculosis and is chronic-destructive in nature which attacks the spine. Manifestations in the form of deformity can also be cosmetically disturbing and will certainly reduce the sufferer's quality of life. The diagnosis of Spinal Tuberculosis is difficult and it commonly presents at an advanced stage. This retrospective study was performed at tertiary general hospital to identify the demographic and presenting clinical features of pediatric Spinal Tuberculosis population. Based on demographic characteristics, it was found that majority patients were female (59.34%) and in the range of 13-18 years old (52.75%). Based on diagnostic characteristics, it was found that majority of the lesions involved the thoracic spine (72.52%), majority of Kyphotic Angle in the range of 0-40 degrees (32.97%), more patients with vertebral collapse damage levels, types of deformity changes, complications of spinal stenosis, the main complaint is back pain and usually followed by weakness in the legs, and the most common patient laboratory results are increased WBC (White Blood Cells), decreased Hgb (Hemoglobin), and increased ESR (Erythrocyte Sedimentation Rate).

Rehabilitation for partial tooth loss of the upper jaw accompanied by tooth abrasion : A case report

Background: When tooth loss is not replaced can cause difficulty in chewing and speaking, Tooth loss can have an impact on the decline of stomatognathic function and aesthetic, which indirectly affects a person's quality of life. Therefore, replacing lost teeth is essential prevent these complications and restore function and appearance. Metal framework RPD is a treatment option has excellent mechanical qualities. Objective: To rehabilitate partial tooth loss of the upper jaw with metal frame removable partial denture. Case Report: A 72 years old female patient came to prosthodontics specialty clinic at Universitas Airlangga Dental hospital with a chief complaint to replace her upper right and left posterior teeth which are lost due to extraction so she can eat properly. The teeth was extracted 3 months ago due to cavities and swelling. The patient reported to have had used partial denture for the past 4 years and currently cannot use them anymore because of the many teeth missing. The treatment chosen for this case is metal frame removable partial denture Conclusion: Metal frame RPD provides satisfaction to the patient and improve aesthetic and function.

Measuring the impact of the economic balance goals on the economic growth of the Iraqi economy for the period (1990-2023)

Achieving economic balance is a multifaceted and ongoing goal. Its achievement requires effective policy making and strategic investments capable of adapting to changing economic conditions. It is a dynamic goal that governments and policy makers around the world seek to achieve for the benefit of their countries by implementing a set of strategies and plans that will Achieving a more balanced and resilient economy, ultimately leading to greater prosperity and improved quality of life for the community. The research aims to determine the impact of the objectives of economic balance (national income, unemployment rate, inflation rate) on economic growth in the Iraqi economy for the period (1990-2023), and to determine the impact of inflation, unemployment, and national income as objectives of economic balance and how they affect economic growth. The researcher relied on the descriptive analytical method, The study also recommended the need for coordination and harmonization between monetary and financial policy so that there is no contradiction between the goals and the possibility of achieving stability, reducing inflation and unemployment rates, and achieving economic growth through testing the limits of co-integration within the autoregressive methodology of distributed time lag based on the existence of a long-term equilibrium relationship between the rate of economic growth and national income. And the rate of unemployment and inflation, although the decline in economic growth was mainly caused by wrong policies and the state’s control over the overall economic activity and the accompanying mismanagement and the inability to diagnose the effective factors in achieving development and the loss of the standards necessary to make appropriate economic decisions, which was reflected in the overall economic activity and was accompanied by that. High unemployment rates in the Iraqi economy.

Case report: Holistic approach to pregnant adolescents

Introduction: Teenage pregnancy is a global health problem with significant impacts on physical, mental, social, and economic health. In Indonesia, the prevalence of teenage pregnancy reaches 10%, with East Java recording a higher rate (12%). Factors such as lack of sexual education, limited access to contraceptives, social stigma, and low family support exacerbate this condition. Case Report: A 14-year-old adolescent girl in Surabaya experienced an unplanned pregnancy and faced limited family support and economic problems. During pregnancy, she experienced eating disorders, anxiety, and limited access to health services. A holistic approach was taken by a midwife, nutritionist, and psychologist, including family counseling, nutrition education, and planning for delivery by caesarean section to prevent complications. Discussion: Teenage pregnancy involves biological, psychosocial, and economic factors. Family and health professional support is essential to reduce the risk of complications such as anemia, preterm labor, and mental health disorders. 5 A holistic approach includes nutrition education, psychological counseling, and family and community support to improve the quality of life of mothers and babies. Continuity of Care (COC) ensures continuity of care from pregnancy, labor, to postpartum. Conclusion: A holistic approach and COC are effective in addressing the challenges of teenage pregnancy with a focus on the following aspects keywords.

Health promotion programs for the development of daily living skills in individuals with neurodevelopmental disorders

The aim of this research is to highlight the health and wellness promotion programs that address the daily lives of people with special educational needs. Health promotion is an approach used to improve the health and quality of life of every person. For many years now, a lot of countries globally have taken advantage of economic and social resources to provide health promoting services in various contexts such as school and community-based facilities. In this review, these frameworks are mentioned, by giving emphasis to health promotion in the community and the enhancement of independent living skills. For people with disabilities, health promotion and the independent living movement has started its activity in recent years, which was a reason chosen to focus on these people, as the literature is limited but the needs in this field vary. The aim of the project is to explore the needs of young people and adults with neurodevelopmental disorders and following a holistic approach, to propose solutions with the various health promotion programs, which may enhance life skills and promote the health, independence and quality of life of people with disabilities.

Baricitinib Provides Significant Improvements in Quality of Life and Functioning in Adults with Moderate-to-Severe Atopic Dermatitis with Baseline Body Surface Area ≤ 40% and Severe Itch.

Patients with moderate-to-severe atopic dermatitis (AD), a body surface area (BSA) of ≤ 40%, and an itch numerical rating scale (NRS) score of ≥ 7 ("BARI itch dominant") have been characterized as an important group to consider for the oral janus kinase (JAK) 1/2 inhibitor baricitinib (BARI). Herein we aim to evaluate quality of life (QoL) and functioning outcomes in adult patients with BSA ≤ 40% and itch NRS ≥ 7 at baseline (BL) who received BARI 4mg in the topical corticosteroid (TCS) combination trial BREEZE-AD7. BREEZE-AD7 was a randomized, double-blind, placebo-controlled, parallel-group outpatient study involving adult patients with moderate-to-severe AD who received once-daily placebo or 2-mg or 4-mg BARI in combination with TCS for 16weeks. Patients eligible for enrollment had to have BSA ≥ 10%. This post-hoc analysis focused on placebo and BARI 4mg for patients with BSA ≤ 40% and itch NRS ≥ 7. QoL impairment was measured using a Dermatology Life Quality Index (DLQI) of ≤ 5, and functioning outcomes were assessed using the Work Productivity and Activity Impairment (WPAI) questionnaire. Data were reported descriptively. Last observation carried forward (LOCF) data were reported, excluding data collected after the first rescue therapy date or permanent study drug discontinuation. Non-responder imputation was used to account for missing data. At BL, patients with BSA ≤ 40% and itch NRS ≥ 7 had high QoL impairment. The mean DLQI score at BL for patients who received BARI 4mg and placebo indicates a very large effect of AD on patients' QoL. Patients who received BARI and placebo experienced a significant itch burden and reported a similar itch NRS. At week 16, 61.5% of patients treated with BARI 4mg indicated that it had no to only a small effect on their QoL (DLQI ≤ 5), versus 24.1% for patients receiving placebo (p < 0.01). A decrease in WPAI work impairment score of - 41.6 for BARI patients and - 7.0 for placebo patients was observed at week 16 (p < 0.01). Patients receiving BARI also observed a noticeable improvement in WPAI daily activity impairment of - 30.4 from baseline at week 16 compared to patients on placebo, who achieved - 12.2 (p < 0.01). Despite having high QoL impairment at baseline, patients with itch-dominant AD treated with BARI 4mg showed marked benefits in QoL, daily life activity, and work function compared to placebo after 16 weeks of treatment. Limitations include the small sample size analyzed.

Assessing the feasibility of measuring residents’ quality of life in English care homes and the construct validity and internal consistency of measures completed by staff proxy: a cross-sectional study

ObjectivesTo assess the feasibility of capturing older care home residents’ quality of life (QoL) in digital social care records and the construct validity (hypothesis testing) and internal consistency (Cronbach’s alpha)...

Multiple system atrophy related neurogenic bladder: mechanism and treatment.

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by its aggressive nature. Its main clinical features include autonomic dysfunction, Parkinson's disease, and cerebellar ataxia. We conducted a comprehensive review of the existing literature, exploring studies and reports related to the mechanisms and treatment of multiple system atrophy related neurogenic bladder. Our aim is to provide a detailed and up-to-date overview of its underlying pathophysiology and current therapeutic strategies. Neurogenic bladder, a common manifestation of MSA, often goes untreated or mistreated, significantly affecting patients' quality of life. Early-stage bladder dysfunction is frequent in MSA patients and correlates with disease severity. The mechanisms of MSA related neurogenic bladder are related to the autonomic nervous system, somatic nerves, frontal cortex, brainstem, and sacral medulla center. Currently, treatment for MSA related neurogenic bladder is mainly symptomatic, and specific drugs are lacking. Further in-depth research is needed to develop more effective therapeutic options that improve patients' quality of life and reduce the risk of complications.

The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy.

Conduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). Data regarding its impact on mortality and morbidity are conflicting. This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health-related Quality of Life (QoL) during the first year after TAVI. In this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, n = 779), PPI before TAVI (PPI pre-TAVI, n = 102), PPI within 30 days after TAVI (PPI post-TAVI, n = 97). All-cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF-12 and EQ-5D-5L questionnaires at baseline and 3, 6, and 12 months. At 1-year, all-cause death was seen in 6.9% (PPI pre-TAVI, p = 0.53) and 10.3% (PPI post-TAVI, p = 0.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre-TAVI, p = 0.58) and 6.2% (PPI post-TAVI, p = 0.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre-TAVI group showed lower PCS-12 over time compared to the no PPI group (p = 0.04), while MCS-12, EQ-5D Index and EQ-5D VAS scores were equal. No significant differences in QoL were seen between the PPI post-TAVI group and the no PPI group. PPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre-TAVI was associated with lower physical QoL.

Quality-of-Life Measurement in Epidermolysis Bullosa. Position Statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient-Oriented Outcomes and External Experts.

In this paper, the European Academy of Dermatology and Venereology (EADV) Task Force on Quality of Life (QoL) and Patient-Oriented Outcomes presents its position statements on health-related (HR) QoL assessment in epidermolysis bullosa (EB). The EADV TF on QoL and Patient-Oriented Outcomes recommends the use of the EB-specific instrument QOLEB in patients over the age of 10 years and, in addition to the QOLEB, the use of iscorEB-p in moderate-to-severe EB; the IntoDermQoL proxy instrument with its EB-specific module should be used in children aged under 5 years. The EB-specific instrument iscorEB-p, and the dermatology-specific instrument CDLQI may measure HRQoL in children with EB aged from 5 to 10 years. Dermatology-specific and/or generic HRQoL instruments should be used to compare the impact on QoL of EB with other diseases; family QoL of patients with EB should be studied using the EB-specific EB-BoD, dermatology-specific family measures, and/or generic family QoL instruments.

Post COVID-19 infection and quality of life of healthcare workers at Sahloul University Hospital of Sousse in Tunisia.

Since the COVID-19 pandemic, health care workers (HCWs) faced an enormous physical and mental burden, sometimes altering their quality of life due mainly to persistent challenges stemming from their frontline position. Todetermine the prevalence of post-COVID-19 syndrome, and its impact on the Health-Related Quality of Life (HRQoL) among HCWs. This is an exhaustive cross-sectional study with analytical scope, conducted among all HCWs of the University Hospital Sahloul of Sousse, Tunisia, who have contracted COVID-19 between September 2020 and 30 March 2021 (N=529 cases).The post-covid medical check-up was carried out three months after the acute phase of the COVID-19 infection (December 2020 to June 2021). HRQoL was assessed using the SF-12 (12-item Short Form Health Survey) questionnaire. Bivariate study and multiple linear regressions were performed to identify the different factors influencing the quality of life of HCWs. During the study period, 529 HCWs were diagnosed with SARS CoV-2 infection, out of them 249 participants were included (47% participation rate). Post covid-19 syndrome was reported in 65% of cases. A low overall quality of life (QoL) score was reported in 28.6% of cases. Low physical and mental composite scores were reported in 34.3% and 29.4% of cases respectively. In the multiple linear regression analysis, gender, post COVID-19 syndrome and time off work were significantly associated with SF12 scores. In our study, HCWs experienced a significant deterioration in HRQoL after COVID-19 with a high incidence of post-COVID-19 syndrome. The need of long-term follow-up after SARS-CoV-2 infection remains essential to support HCWs and mitigate long-term impacts.

Effect of a Nurse-Led Omaha System-Based Mobile Health Application in Managing Symptoms and Enhancing Quality of Life in Patients With a Communicable Disease: A Randomized Controlled Trial.

This study investigated the effects of a nurse-led Omaha System-based mobile health application on physical, psychosocial, and cognitive symptoms and quality of life in patients with COVID-19 followed at home. This randomized control trial was conducted on 60 patients followed at home (30 in each intervention and control group). The intervention group received a nurse-led Omaha System-based mobile health application named COVOS, and the control group received usual care. Compared with the control group, the physical symptoms of the intervention group were significantly reduced at all follow-ups (first, second, and third months; P < .05). Psychosocial symptoms (depression, anxiety, stress) were significantly reduced, respectively, in the intervention group at all follow-ups: first and third months and second and third months (P < .05). Cognitive symptoms were significantly reduced in the first month in the intervention group (P = .014). Similarly, the physical component score of quality of life significantly improved in the first month, and the mental component score of quality of life significantly improved in the second and third months (P < .05) in the intervention group. Results suggest that the COVOS had the potential to reduce effectively the physical, psychosocial, and cognitive symptoms of patients with COVID-19 and improve the quality of life of patients with COVID-19 followed at home.

Effectiveness of Pelvic Floor Muscle and Education-based Therapies on Bladder, Bowel, Vaginal, Sexual, Psychological Function, Quality of Life, and Pelvic Floor Muscle Function in Females Treated for Breast Cancer: A Systematic Review.

Breast malignancy is the most common cancer in females. Symptoms of pelvic floor disorders and sexual dysfunction secondary to systemic cancer treatment may occur. Non-surgical, non-pharmaceutical conservative therapies, namely pelvic floor muscle (PFM) and education-based therapies, could be beneficial to reduce these symptoms in this population. This systematic review aimed to examine the evidence regarding their effectiveness on bladder, bowel, vaginal, sexual, psychological function, quality of life, and PFM function in breast cancer populations. Six databases were searched to identify interventional studies on the effect of PFM therapies, education-based therapies, or combined (multimodal) therapies on any outcome of interest. The search yielded 603 results, from which 12 studies were included. Of these, six (50%) were RCTs, one (8%) was a non-RCT with two groups, and five (42%) were non-RCTs with a single group. Findings suggest that PFM therapies (active) may be beneficial, and education in the format of CBT may improve bladder function. No data were found for bowel function and results from two RCTs were inconclusive to draw conclusions for vaginal function. Sexual function was the most frequently reported outcome. PFM therapies (active > passive) may be beneficial, and education is more likely than not to improve sexual function. For psychological function, PFM therapies (active + passive) may be beneficial, and education is more unlikely than likely to improve psychological function. For quality of life, PFM therapies (active + passive) may be beneficial, and education is more unlikely than likely to improve quality of life, although CBT combined with physical exercise may provide further improvement. PFM therapies (active ± passive) may improve PFM function. Given the limited number of studies and their methodological limitations, caution should be exercised when interpreting these study results. More research is needed to confirm findings and to investigate the clinical value of PFM therapies and combined, multimodal therapies for breast cancer populations. Non-surgical, non-pharmaceutical conservative therapies may be helpful for breast cancer populations. Clinicians should consider the highest level of available evidence to guide their practice and use their clinical judgement to select the treatment components and appropriate dosages.

Endovascular Coiling Combined With Tissue Glue Embolism to Treat 20 Cases of Iliac Arteriovenous Fistula Secondary to Deep Vein Thrombosis.

The objective of this study is to assess the feasibility of endovascular coiling combined with tissue glue embolism for the treatment of iliac arteriovenous fistula (AVF) secondary to deep vein thrombosis (DVT) of the lower extremities. In addition, we aim to summarize the treatment methods and enhance understanding of the disease. This research analyzes the clinical data and medical imaging materials of 20 cases with iliac AVF secondary to lower extremity DVT, ranging from December 2014 to December 2020, at our hospital. The patients underwent endovascular coiling and tissue glue embolism during their hospital stay. We collected and summarized the clinical and imaging data, evaluated the efficacy of treatment methods, assessed the incidence of complications, and conducted long-term follow-up observations. All 20 surgeries were successful. Endovascular coiling combined with tissue glue embolism significantly relieved limb swelling. The diameter difference above the patella in patients before and after treatment was 9.38±3.58 versus 4.13±1.64 cm, P<0.001. No serious complications occurred during treatment, and no patients showed signs of AVF recurrence during follow-up after surgery. Endovascular coiling combined with tissue glue embolism can be used to treat iliac AVF secondary to DVT of the lower extremities, which has high clinical value and is safe. For clinicians, AVF secondary to DVT is a complication that cannot be ignored. It also needs to be treated aggressively to improve patients' quality of life. We presented a minimally invasive method to treat iliac arteriovenous fistula secondary to deep vein thrombosis of lower extremities, which is also an innovative intervention technique. Endovascular coiling combined with tissue glue embolism can achieve better embolic blockade in this type of iliac arteriovenous fistula. This will move the management of postoperative complications in the direction of minimally invasive.

Return-to-work in lung transplant recipients: an Australian perspective.

Return-to-work (RTW) following lung transplant has been associated with increased quality of life, but little is known regarding the rates of and barriers to this in the Australian population. We aimed to describe, characterise and determine predictors of return to work and social participation in Australian lung transplant recipients. We also sought to explore the relationship between return to work and quality of life. We conducted a cross-sectional questionnaire-based study at the Alfred Hospital, Melbourne between October 2018 and August 2019. The questionnaire evaluated demographics, transplant history, respiratory parameters, employment history and social integration prior to and after lung transplantation. A total of 172 lung transplant recipients were included for analysis. The population was mostly male (56.5%), median age 61 years (interquartile range (IQR) 49.8-67.0) and median time from transplant 4 years (IQR 2-7). A total of 19.2% of patients were working at time of transplant, with 35.5% working after transplant representing an increase in workforce engagement of 84.8% (P < 0.001). A total of 96% of those who returned to work reported an improvement in quality of life. Median time to RTW after transplant was 180 days (IQR 90-360). Multivariable analysis demonstrated an increased rate of RTW in younger recipients (odds ratio (OR) 0.94, 95% confidence interval (CI) 0.89-0.99, adjusted P = 0.029), at greater length of time after transplant (OR 1.09, 95% CI 0.99-1.19, P = 0.084), among those working at the time of transplant (OR 9.55, 95% CI 2.70-33.75, P < 0.001) and with higher socioeconomic status (OR 1.02, 95% CI 1.01-1.04, P = 0.009). Recipients with cystic fibrosis were more likely to RTW (65.8%) than those with other underlying conditions. RTW should be encouraged in lung transplant recipients. Targeted supports and resources aimed at younger recipients may result in greater workforce engagement and overall outcomes after transplant.