Qualitative Correlation Research Articles

Modeling of “combined cutter - cone” connection in tricone drill bits

A theoretical analysis of the stiffness of the “cutter-cone” connection was performed. In the article the character and magnitude of the tension at the contact of "cutter-cone" are investigated. An analysis of the surface of the openings for carbide inserts revealed traces of plastic deformation and fretting wear. Since the contact bond of the cutter with the body of cone is the only factor that provides the strength of the connection, let consider the effect of mechanical properties of the cones body and a cutter on the magnitude of the forces of contact and tension in the connection. The surface of the shaft of this design consists of equal parts of solid alloy and steel. If you make a ring at a smaller diameter of the shank of a carbide cutter, this will increase the reliability of the connection of the insertion with the body of the rock cutting tool, optimize toughness of cutter fastening, and ensure high stability of the hard-alloyed inset cutter before fracture. As a result of the conducted researches, a qualitative correlation between the hardness of the carbide insertion fastening in the holes of cone and the nature of the destruction of the carbide cutters has been established. Due to the conducted research, the character of the distribution of contact tensions in the conjugated areas “combined cutter - a hole of cone” was established. The theme of the development of new rational constructions of rock-destructive equipment of cones, rock-destructive inserts, schemes of its effective arrangement on the brushes of cone is still actual. A separate issue of further research is the study of functional and energy interaction of elements of propulsion and rock-destructive equipment.

Deep eutectic solvents based on choline chloride and ethylene glycol as media for extractive denitrification/desulfurization/dearomatization of motor fuels

In an attempt to develop alternative methods that meet the criteria of ‘green’ technology in gasoline production, choline chloride and ethylene glycol (ChCl-EG) based deep eutectic solvents (DESs) in molar ratios of 1:2, 1:3 and 1:3.5 were tested for desulfurization, denitrification and dearomatization of model and real gasoline. Using ChCl-EG 1:3.5 denitrification efficiency of 70.9% with respect to pyridine was achieved in a single extraction stage; efficiency above 99% was obtained in four stages. The DESs were regenerated by evaporating extracted components between stages, allowing for its multiple use. The equilibrium phase compositions in model fuel experiments were fairly predicted by UNIQUAC model. Physical properties of DESs important for application as extraction solvents were determined, too. The extraction data collected on real fuels shown that only the loose qualitative correlation with the model fuel experiments can be established.

Determination of Hydrocarbon Zones Using Logging Data Analysis in A Sandstone Reservoir (Case Study: Structure ‘TL’ Basin North West Java)

DOI: 10.17014/ijog.5.3.251-263Northwest Java Basin is one of the Indonesian basins that has the potential of hydrocarbon reservoir. A petrophysical analysis plays a role in determining the physical properties of reservoir rocks such as shale volume, porosity, and water saturation zones which is to analyze the hydrocarbon zone possibilities (net pay). A qualitative analysis and correlation of rock lithology study were carried out at seven wells, while a quantitative study was performed by calculating the volume of the shale with a linear method, density-neutron porosity, and water saturation using simandoux equation, then zoning the prospect zones was finally done. Based on the calculation and data analysis, Vsh cutoff value obtained is 23%, the porosity is 10.6%, and water saturation is 71%. Then, the zones of hydrocarbon prospects were recovered, that are the PI-08 wells (9.632 ft - 9.662 ft), PI-10 (9.420 ft - 9.468 ft, 9.475 ft - 9.516 ft, 10.155 ft - 10.175 ft), well PI-11 (9.268 ft - 9.288 ft), well PI-11ST (9.268 ft - 9.927 ft), well PI-12 (9.396 ft - 9.461 ft, 10.047 ft - 10.059 ft), and PI-13 wells (9.356 ft - 9.416 ft, 9.980 ft - 10.000 ft).

Spatial and Temporal Features of Synoptic and Mesoscale Variability of the Baltic Sea Level

The spatial and temporal features of synoptic and mesoscale variability of the Baltic Sea level are studied using long-term hourly data. The spectral analysis revealed significant difference in the structure of the sea level spectra between the Gulf of Bothnia and the Gulf of Finland. The maximum variance of the synoptic sea level variability is observed at the head of the Gulf of Bothnia and in the southwestern part of the Baltic Sea, whereas the maximum variance of mesoscale variability is registered at the head of the Gulf of Finland and in the southwestern part of the sea. The minimum variance of synoptic sea level variability was observed in the Gulf of Bothnia in the 1950s–1960s, and the maximum was recorded at the beginning and at the end of the 20th century. The series of interdecadal variability of synoptic sea level fluctuations have a weak negative trend up to −0.11 cm2/year in Kungsholmfrost. A significant qualitative and quantitative correlation was detected between the interannual variability of variance of mesoscale sea level variations in the Gulf of Finland (Gornyi Institut) and the Gulf of Riga (Parnu) and the interannual variability of the NAO index.

Correlation of fabric tensors for granular materials using 2D DEM

Soil fabric anisotropy can be quantitatively assessed by means of fabric tensors introduced as internal variables in constitutive models and defined by unit vectors along the directions of different orientation microstructural entities such as particle long axes, inter-particle contact normal vectors and void vectors. The most common choice is a fabric tensor based on contact normal directions. However, contact normal directions are more difficult to determine experimentally, due to difficulties associated with accurate measurement of tangent contact planes. The main scope in this study is to seek for possible correlations for fabric tensors defined using different fabric entities, i.e., contact normal, void and particle orientation vector directions, and based on this correlation to suggest the two latter instead of the first one because of the easiness of their measurements. The void fabric is defined using a very recent contribution of the authors concerning a modified and a novel approach of the scan line method for the determination of appropriate void vectors by means of 2D discrete element method analysis. In this very recent work of the authors, a first qualitative correlation was detected between contact normal and void fabric for both the void fabric tensors used therein. Given that this observation concerned only one 2D test, the current work aims at presenting an extended parametric analysis on the correlation of fabric tenors for all the above-mentioned fabric entities.

Autogenous self-healing of cement with expansive minerals-II: Impact of age and the role of optimised expansive minerals in healing performance

This part of the study presents the optimisation of expansive minerals mix proportions and establishes a quantitative and qualitative correlation between self-healing and the cracking age of cementitious materials. The hydration degree of cementitious materials is considered as a quantitative measure of age and the corresponding healing performance was analysed to establish an age-healing relation. Healing performances were assessed in terms of load recovery, crack sealing efficiency and gas permeability. The microstructure of materials was investigated using XRD, TGA and SEM-EDX. The self-healing performance of particular cement mixes shows linearly increasing correlation with the reduction of hydration degree. However, cement mixes containing expansive mineral result in higher healing performance than mixes containing only Portland cement (PC). This observation was confirmed for all cracking ages. Blends containing only PC showed healing materials that were mostly calcite and portlandite, while the optimised use of expansive minerals produced denser healing materials with C-S-H, and complex Ca, Mg, Si, Al combined hydrated and carbonated products in addition to calcite and portlandite. The results further suggest that the proportions of calcite, portlandite and ettringite in healing compounds have an increasing trend with the age of hardened cementitious materials.

Fire Resistance of In-Plane Compressed Log-House Timber Walls with Partial Thermal Insulation

This paper presents the full-scale experimental assessment of a log-house timber wall with partial thermal insulation under in-plane compression and exposed to fire on one side. A key aspect of the current design application for log-house systems is represented by geometrical details, like cross-sectional properties of logs (typically characterised by high depth-to-width ratios) and outriggers. The latter provides restraint condition for the examined walls and hence markedly affects their overall load-carrying capacity. As a result, careful consideration should be given to the choice of these details, compared to fully monolithic timber walls (i.e., made from cross-laminated timber), due to the possible occurrence of local structural and/or thermo-mechanical mechanisms. This is the case of exceptional loading conditions like fire load, as the fire resistance of these systems could be affected by a multitude of variables, including the presence (even though limited to few surfaces only) of thermal insulation panels. To this aim, the results of a full-scale furnace test are discussed in the paper for a log-wall with partial thermal insulation, namely thermal insulation applied on the outriggers only, under the effects of EN/ISO standard fire conditions. The results of Finite Element (FE) numerical studies are also reported, to further explore the load-carrying performance of the reference log-house specimen and compare it with the experimental observations. Several thermal insulation configurations are finally numerically investigated, showing their effects on the overall fire resistance of the assembly. In accordance with literature, the test shows that the log house’s timber wall is suitable to obtain a fire resistance of about 60 min under relevant loading. The FE results are in rather close agreement with the temperature measurements within the section of logs, as well as a qualitative correlation with respect to the mechanical behaviour observed in the full-scale furnace experiment. The key role of outriggers and their thermo-mechanical boundaries, finally, is emphasised.

Thiophene and its sulfur inhibit indenoindenodibenzothiophene diradicals from low-energy lying thermal triplets.

Many qualitative structure-property correlations between diradical character and emerging molecular properties are known. For example, the increase of diradical character further decreases the singlet-triplet energy gap. Here we show that inclusion of thiophenes within a quinoidal polycyclic hydrocarbon imparts appreciable diradical character yet retains the large singlet-triplet energy gap, a phenomenon that has no precedent in the literature. The low aromatic character of thiophene and its electron-rich nature are the key properties leading to these unique findings. A new indenoindenodibenzothiophene scaffold has been prepared and fully characterized by several spectroscopies, magnetic measurements, solid-state X-ray and state-of-the-art quantum chemical calculations, all corroborating this unique dichotomy between the diradical input and the emerging magnetic properties. New structure-property relationships such as these are not only extremely important in the field of diradical chemistry and organic electronics, but also provide new insights into the versatility of π-electron chemical bonding.

Qualitative and quantitative correlation of physicochemical characteristics and lead sorption behaviors of crop residue-derived chars

This study investigated the key physicochemical characteristics of char that control its ability to absorb Pb2+. Three type of crop residue-derived chars and their ball milled powder were characterized using multiple approaches. The Pb2+ sorption mechanisms of biochar were caused mainly by coprecipitation reactions, which were governed by ionic minerals on chars instead of mineral crystallization (e.g., SiO2 and Al2O3), while coprecipitation reactions and π electronic interaction were the dominant mechanisms of activated carbon. Pearson analysis showed that adsorption quantity (Q) highly correlated with the cation exchange capacity (CEC) (P < 0.01)/oxygen functional groups (OFGs) (P < 0.05) and Q closely correlated with coprecipitation amount (P < 0.01)/complexation amount (P < 0.01). Linear regression equations of sorption amount and CEC (R2 ＞ 0.8)/OFGs (R2 ＞ 0.7) were established. CEC and OFGs of chars are the key factors controlled Pb2+ sorption. These results may promote the development of low-cost, engineered biochar with superior sorption qualities for environmental remediation.

Investigation of diverse interactions of amino acids (Asp and Glu) in aqueous Dopamine hydrochloride with the manifestation of the catecholamine molecule recognition tool in solution phase

The density (ρ), viscosity (η) and conductivity (Ʌ) studies of Aspartic Acid and Glutamic Acid in aqueous solution of Dopamine hydrochloride were carried out at three different temperatures having an interval of 10 K under atmospheric pressure. The experimental data were methodically used to enumerate various thermophysical parameters which assist to gather information about the presence of plausible intermolecular interactions in the ternary (Dopamine hydrochloride + water + amino acids) system. The results were interpreted in terms of various Dopamine hydrochloride-amino acid intermolecular interactions through a cosphere overlap model. In this article, we also focused on spectroscopic methods like UV–Visible, Nuclear Magnetic Resonance spectroscopy and Raman spectroscopy to ensure the nature of drug–amino acid interaction in solution phase. The Benesi-Hildebrand method was used to calculate the binding constants for both the amino acids in ternary system. The Gibbs free energy change of the system was calculated indicating spontaneity of the systems. Hydrogen bonding along with ionic-hydrophilic interactions was observed as significant factors for such interactions. Furthermore, structure making behaviors of both amino acids were detected in aqueous Dopamine hydrochloride. These calculated parameters were found to be sensitive towards the interactions prevailing in DH-amino acids system. Convincingly existence of a good qualitative correlation is observed with regard to DH-Glu interactions obtained from the measurements. The experimental and correlated data could be used in the development of models for mixtures of drug molecules with amino acids.

Mathematical Modeling of Linear Docking. II. Estimating the Effect of Point Mutations on the Affinity between Protein Molecules

A new method enabling the qualitative determination of the dissociation constant of peptides to full-length proteins and the estimation of the effect of point mutations in peptides on the stability of a formed complex with whole proteins was presented. Based on the developed approach, a qualitative correlation was revealed between the obtained results and the dissociation constant using the formation of a biocomplex of the Bmf, Puma, Bad, Hrk, Bax, Bik, Noxa, Bid, Bim, and Bak BH3-peptides and the Bcl-xl protein and a biocomplex of the Bax BH3-peptides and the Bcl-2 protein with consideration for the replacement of amino acid residues as an example.

Quantitative and qualitative correlation analysis of optimal route discovery for vehicular ad-hoc networks

Vehicular ad-hoc networks (VANETs) are a significant field in the intelligent transportation system (ITS) for improving road security. The interaction among the vehicles is enclosed under VANETs. Many experiments have been performed in the region of VANET improvement. A familiar challenge that occurs is obtaining various constrained quality of service (QoS) metrics. For resolving this issue, this study obtains a cost design for the vehicle routing issue by focusing on the QoS metrics such as collision, travel cost, awareness, and congestion. The awareness of QoS is fuzzified into a price design that comprises the entire cost of routing. As the genetic algorithm (GA) endures from the most significant challenges such as complexity, unassisted issues in mutation, detecting slow convergence, global maxima, multifaceted features under genetic coding, and better fitting, the currently established lion algorithm (LA) is employed. The computation is analyzed by deploying three well-known studies such as cost analysis, convergence analysis, and complexity investigations. A numerical analysis with quantitative outcome has also been studied based on the obtained correlation analysis among various cost functions. It is found that LA performs better than GA with a reduction in complexity and routing cost.

Залежність успіху в бою (операції) від початкового співвідношення сил і засобів сторін та ступеня фортифікаційного обладнання смуги оборони

In the article, based on the analysis of historical examples and provisions of the combat (field) charters, a methodological approach is proposed to predict the success of the parties in the battle (operation), depending on the qualitative initial correlation of forces and means of the parties and the degree of fortification equipment of the defense strip. The proposed methodological approach may be the basis for improving the methodology for evaluating variants of the method of conducting an operation (battle).

Effect of plating bath composition on chemical composition and oxygen reduction reaction activity of electrodeposited Pt–Co catalysts

Platinum–cobalt (Pt–Co) alloy electrocatalysts were prepared on pretreated carbon cloth by electrodeposition from different plating baths with the aim of finding suitable plating bath conditions that could control the chemical composition of the Pt–Co alloy electrodeposits over a wide range (from 0 to 100 at% Pt) and then to study the relationship of the deposit composition on the oxygen reduction reaction (ORR) electroactivity. The type of supporting electrolyte, the solution pH, Pt and Co concentrations of the plating bath and the current density used for electrodeposition all play a crucial role in the composition of the electrodeposited Pt–Co alloy. Pt contents in all the Pt–Co alloys deposited in H2SO4 are at a relatively high and narrow level (83 at%–97 at% Pt), regardless of the electrodeposition conditions used. While the Pt contents in the Pt–Co alloys deposited in Na2SO4 could reach a very low and broad level (5 at%–97 at% Pt), evidence of Co oxide formation is observed. Of the three supporting electrolytes studied, only NaCl effectively produces Pt–Co deposits over a wide range of compositions (8–90 at% Pt) by controlling the Pt and Co concentrations of the plating bath and using the high enough current density. The results show a qualitative correlation between Pt–Co deposit composition and ORR activity, where Pt–Co alloy catalysts with ≥ 45 at% Pt tend to yield higher ORR activities than the pure Pt catalyst, with the best ORR performance obtained from the Pt–Co alloy catalyst with 78 at% Pt.

Combined Tip-Enhanced Raman Spectroscopy and Scattering-Type Scanning Near-Field Optical Microscopy

Tip-enhanced Raman spectroscopy (TERS) and scattering-type scanning near-field optical microscopy (s-SNOM) enable optical imaging with a spatial resolution far below the diffraction limit of light. Although s-SNOM records the elastically scattered light (yielding information about the local refractive index and absorption), in TERS, the Raman scattered light is detected, which provides, for example, chemical information. Here, we introduce a combined TERS and s-SNOM setup for correlative studies of tip-enhanced elastically scattered and Raman scattered light. To that end, we equipped a conventional s-SNOM with a grating spectrometer. We validate our setup by characterizing a sample consisting of a self-assembled para-nitrothiophenol monolayer on an Au surface. Comparing s-SNOM and TERS signals, we demonstrate a qualitative correlation between the tip-enhanced elastic and tip-enhanced Raman scattered light. Thus, recording the tip-enhanced elastically scattered light enables a fast and reliable TERS alignm...

A Qualitative and Quantitative Correlation Study of Lumbar Intervertebral Disc Degeneration Using Glycosaminoglycan Chemical Exchange Saturation Transfer, Pfirrmann Grade, and T1-ρ.

Glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging allows the direct measurement and mapping of glycosaminoglycans. In this study, we aimed to evaluate the usefulness of gagCEST imaging in the quantitative assessment of intervertebral disc degeneration in a comparison with Pfirrmann grade and T1-ρ measurements. Ninety-six lumbar intervertebral discs in 24 volunteers (36.0 ± 8.5 years of age, 21 men and 3 women) were examined with both gagCEST imaging and T1-ρ measurements. The gagCEST imaging was performed at 3T with a saturation pulse with 1.0-second duration and the B1 amplitude of 0.8 μT followed by imaging by a 2D fast spin-echo sequence. The Z-spectra were obtained at 25 frequency offsets from -3 to +3 ppm (step, 0.25 ppm). A point-by-point B0 correction was performed with a B0 map. The gagCEST signal and T1-ρ values were measured in the nucleus pulposus in each intervertebral disc. The Pfirrmann grades were assessed on T2-weighted images. The gagCEST signal at grade I (5.36% ± 2.79%) was significantly higher than those at Pfirrmann grade II (3.15% ± 1.40%, P = .0006), grade III (0.14% ± 1.03%, P < .0001), grade IV (-1.75% ± 2.82%, P < .0001), and grade V (-1.47% ± 0.36%, P < .0001). The gagCEST signal at grade II was significantly higher than those of grade III (P < .0001), grade IV (P < .0001), and grade V (P < .0001). The gagCEST signal was significantly correlated negatively with Pfirrmann grade (P < .0001) and positively correlated with T1-ρ (P < .0001). GagCEST imaging could be a reliable and quantitative technique for assessing intervertebral disc degeneration.

Correlation of Epistemic Curiosity and Cognitive Understanding Biology’s Student in Health and Pharmaceutical Biotechnology

Technology growing rapidly because technological development is required in all aspects of humanlife. Biotechnology is one of the branch of biology that is constantly evolving. Health andpharmaceutical biotechnology is one of the biotechnology which became the spotlight of the world.Biotechnology is part of science that commences from curiosity. One of curiosity type is epistemiccuriosity (EC). Epistemic curiosity contribute to give problem solving for the appearing issue. Thisneed higher order thinking. Higher order thinking need good cognitive understanding. The purpose ofthis study is to: 1) describe the epistemic curiosity (EC) Biology’ student to the development of healthand pharmaceutical biotechnology, 2) analyzing the correlation of epistemic curiosity (EC) andcognitive ability of biology’ student in health and pharmaceutical biotechnology. This researchincludes descriptive correlative with the research data is a cognitive understanding and EC ofbiology’ student. Cognitive understanding and EC data taken using a questionnaire (i-d scalecuriosity) and problem (the quiz). Average of EC scores is 26,1. A descriptive analysis of the averageEC is of 65.3% (high category). The average of student's cognitive understanding is 38.8%. (lowcategory). Quantitative correlation of cognitive understanding and EC was 0,208 (weak category).Qualitative correlation of cognitive understanding and EC was J category, that have a high EC butlow cognitive understanding.

Quantitative Evaluation of Key Geological Controls on Regional Eagle Ford Shale Production Using Spatial Statistics

Summary Recent progress has increased our understanding of key controls on the productivity of shale reservoirs. The quantitative relations between regional Eagle Ford Shale production trends and geologic parameters were investigated to clarify which geologic parameters exercise dominant control on well-production rates. Previously, qualitative correlations for the Eagle Ford Shale were demonstrated among depth, thickness, total organic carbon (TOC), distribution of limestone beds, and average bed thickness with regional production. Eagle Ford production wells are horizontal, but it was necessary to use vertical wells that penetrated the Eagle Ford to map reservoir properties. No wells in the database had both production and geological parameters, and thus geological parameters could not be directly related to individual-well production. Therefore, spatial-interpolation methods derived from the Kriging and Bayesian methods with Markov-chain Monte Carlo (MCMC) sampling algorithms were used to integrate data sets and predict geological properties at production-well locations. The spatial Gaussian-process-regression modeling was conducted to investigate the primary controls on production. Results suggest that the 6-month cumulative production from the Eagle Ford Shale, in barrels of oil equivalent (BOE), increases consistently with depth, with Eagle Ford thickness (up to 180-ft thickness), and with TOC (up to 7%). Also, when the number of limestone beds exceeds 12, production increases with the number of limestone beds. The corresponding significance code indicates that the parameters most significant to production are TOC and depth (which relates to pressure and thermal maturation). Concepts and models developed in this study may assist operators in making critical Eagle Ford Shale development decisions and should be transferable to other shale plays.

PATHOMORPHOLOGICAL FEATURES OF BONE LESIONS AND CORRELATION OF CLINICAL, LABORATORY AND MORPHOMETRIC CRITERIA IN PATIENTS WITH LATENT SCLEROSING HEMATOGENOUS OSTEOMYELITIS (GARRÉ)

Introduction. Sclerosing hematogenous osteomyelitis of Garré (SHO) holds a significant place among cases of latent hematogenous osteomyelitis. Pathomorphological studies of sclerosing hematogenous osteomyelitis are needed to improve differentiated diagnostics, to prognosticate morphology specifics of nidus and to choose the optimal treatment tactics.Purpose of the study — to identify statistical differences between manifestation patterns of various disease types and correlation between clinical, laboratorial and morphometric criteria of bone lesions in patients with sclerosing hematogenous osteomyelitis.Material and methods. The authors studied tissue fragments of affected bones of 25 patients with SHO which was diagnosed by clinical, laboratorial, visualizing and morphological methods. Gradation morphometric criteria were used to reflect condition of nidus tissues. The authors made the analysis of qualitative characters and correlation analysis of dependencies between clinical and laboratorial criteria on the one hand, and with morphometric criteria — on the other, and identified association factor. Results. Pathomorphological study of SHO nidus demonstrated variances of bone lesions in separate disease cases despite the overall similarity of morphological manifestation. About 2/3 of all cases correspond to fibrosing type whereby even small exudative inflammation sites are absent. In about 1/3 of all cases apart from fibrosis, osteosclerosis and remodeling, the osteomyelitis niduses contain microabscesses indicative of suppurative inflammation as well as the authors observed small sequestration. The maximum differences in patients with various types of SHO were identified in such parameters as share of stab microphages and erythrocyte sedimentation rate (ESR). In cases of long term morbidity the fibrosing disease type is prevailing, in cases of short term lesion (1–2 years) — a fibrosing type with microabscesses formation.A series of correlation dependencies was reported between clinical and laboratorial criteria on the one hand, and with morphometric criteria — on the other hand.Conclusion. Pathomorphological features of bone lesions in sclerosing hematogenous osteomyelitis are nonhomogeneous. Every case in the study demonstrated stereotype alterations such as substantial diffuse fibroses of marrow spaces in cancellous bone and bone regenerate, remodeling of bone tissues with gradual acceleration of osteosclerosis and persisting productive inflammation. Only in sone cases featured small sites of exudative inflammation — microabscesses with microsequestration.

Albumin biofunctionalization to minimize the Staphylococcus aureus adhesion on solid substrates.

Staphylococcus aureus has become the most common opportunistic microorganism related to nosocomial infections due to the bacteria capacity to form biofilms on biomedical devices and implants. Since bacterial adhesion is the first step in this pathogenesis, it is evident that inhibiting such a process will reduce the opportunity for bacterial colonization on the devices. This work is aimed at optimizing a surface biofunctionalization strategy to inhibit the adhesion of S. aureus on solid substrates. The first part of the work deals with the albumin adsorption-desorption process, studied by a factorial design of experiments to explore a wide range of experimental factors (protein concentration, pH, flow rate and adsorption time) and responses (initial adsorption rate, adsorbed amount, desorbed extent) for hydrophilic and hydrophobic substrates, with a reduced number of experiments. This approach allows the simultaneous evaluation of the factors affecting the albumin adsorption-desorption process to find a qualitative correlation with the amount of alive S. aureus adhered on albumin biofunctionalized substrates. The results of this work point to a relationship between bacterial adhesion and the degree of albumin relaxation on the solid substrate. In fact, the inhibition of bacterial adhesion on albumin biofunctionalized substrates is due to the surface perturbation on the native structure of the protein. On this base, a biofunctionalization strategy was designed using a solution of thermally treated albumin molecules (higher β-sheet or unordered secondary structure elements) to biofunctionalize solid substrates by dipping. With these albumin biofunctionalized substrates S. aureus adhesion was minimized.