Land-use change is a hot issue in global change research. Ecological security caused by land-use change at different spatial time scales is also one of the hot issues of research. This paper selects the plateau lakes in China as the study area, explores the land-use change in the basin from 1989 to 2015, and uses the pressure-state-response (PSR) model to analyze the ecological security of the Central Yunnan Basin qualitatively. According to the research, from 1989 to 2015, the annual change rate of integrated land-use dynamics in the basin was 0.66%; the 1989 and 2015 ecological safety indexes of Qilu Lake were 0.5912 and 0.5845, respectively, all in a “poor” safety state. From the perspective of the system as a whole, the pressure of natural and humanities has the most significant impact on the ecological security assessment of the basin. According to the research, it provides a theoretical basis for the ecological security construction of the plateau lakes in China.
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