Fractional calculus has been a concept used to obtain new variants of some well-known integral inequalities. In this study, our main goal is to establish the new fractional Hermite–Hadamard, and Simpson’s type estimates by employing a differentiable function. Furthermore, a novel class of fractional integral related to prominent fractional operator (Caputo–Fabrizio) for differentiable convex functions of first order is proven. Then, taking this equality into account as an auxiliary result, some new estimation of the Hermite–Hadamard and Simpson’s type inequalities as generalization is presented. Moreover, few inequalities for concave function are obtained as well. It is observed that newly established outcomes are the extension of comparable inequalities existing in the literature. Additionally, we discuss the applications to special means, matrix inequalities, and the q-digamma function.