The main therapeutic approach to toxoplasmosis is a combination of pyrimethamine and sulfonamides.Wilson's disease (hepatolenticular degeneration) responds to a copper-poor diet and agents that remove copper from the tissues. Two new anticholinesterases used to treat glaucoma are Phospholine iodide and demecarium bromide. Compounds to reverse the action of anticholinesterases also are being studied, e.g., 2-pyridine aldoxime methiodide.Neostigmine administered locally may help control the ocular manifestations of myasthenia gravis and aid in diagnosis.Steroids given for systemic diseases may produce unusual ocular side effects, and some drugs that may be instilled in the eye may produce serious systemic disorders. Tranquilizers also have produced some unusual complications.