Pyrazoline Derivatives Research Articles

Plastic Scintillators and Radiation Detectors Based on Triphenyl Pyrazoline Derivatives

AbstractPlastic scintillators (PS) allow design of portative lightweight devices for quantification of low‐activity radiation sources. We have recently suggested a new type of organic fluorophores based on triphenyl pyrazoline (PZ) derivatives with high fluorescence quantum yield showing high radioluminescence when combined with a polyvinyltoluene (PVT) matrix. In this publication we report on radioluminescence properties of the PZ−X family with various halogen substitution (X=F, Cl, Br, I), or having vinyl functional group (vPZ, X=vinyl). PS based on such fluorophores and PVT matrix can be prepared as bulk samples, micrometer size beads or cladding on optical fibers. Application of fluorophores with vinyl functional groups enabled their enhanced interaction with the matrix due to covalent bonding between the components. We demonstrate high performance of PZ−X fluorophores and especially vPZ fluorophore in fabrication of nanocomposites for detection of various types of radiation. Scintillators have enhanced gamma ray detection capabilities with an addition of triphenyl Bi, or Gd2O3 nanoparticles. High fluorescence quantum yield and luminosity of PZ fluorophores allows dramatical reduction of their content in PS systems. Mechanisms of energy transfer and conversion during scintillation process are discussed. Special consideration is given to enhancement of α/β and neutron/gamma (n/γ) pulse shape discrimination (PSD) function of the developed scintillators.

Synthesis, characterization, docking study and biological evaluation of new chalcone, pyrazoline, and pyrimidine derivatives as potent antimalarial compounds

Malaria is a protozoan disease caused by a unicellular parasite named Plasmodium (Phylum- Apicomplexa). World Health Organization has estimated roughly fifty percent of the world’s community lives under the continuing threat of malaria. The focus of drug discovery has increased towards valuable structures known as chalcones, pyrazoline, and pyrimidine due to their extensive bioactivity in malaria treatment. In this study, four chalcone derivatives (1–4) have been synthesized via the Claisen-Schmidt condensation. New compounds of 12 pyrazolines (1–4)Ai-iii and eight pyrimidines, (1–4)Bi-ii derivatives have also been synthesized via a ring-closing reaction of the chalcones. All the synthesized compounds were characterized and tested against malaria. The results showed that compound 1Aiii exhibited significant antiproliferative effects against 3D7 and RKL9 with 3D7 = 2.1 μg/mL, IC80 3D7 = 8 μg/mL, and IC50 RKL9 when exposed to compared to the reference anticancer drug, CQ Chloroquine diphosphate, and Artemisinin. The molecular docking analysis showed that compounds 1, 1Aiii and 1Bi had entered the PfATP4 receptor pocket and had been stuck with the amino acids in a high affinity of binding.

Synthesis of 3,5-Diphenyl Pyrazoline Derivatives, In Silico ADME Screening, Evaluation of Antimicrobial and Antimycobacterial Activities

Objective: The unconscious widespread use of antibiotics leads to the development of resistance to antibiotics. When resistance to an antibiotic develops, it now either shows less efficacy or loses its effect completely at that antibiotic treatment dose. While the development of resistance to antibiotics increases rapidly, the need for the development of new antibiotics rises every day. For this purpose, in this study, antimicrobial and antitubercular effects of some compounds in the pyrazoline structure were investigated. The physicochemical properties and drug-likeness of the compounds are quite important for determining whether a compound can be used as a drug or not. Physicochemical properties and drug-likeness of the synthesized compounds were evaluated and the relevance for Lipinski’s rules was determined. Material-Method: Drug-likeness properties of the synthesized compounds were determined using online Swiss ADME tool. Antitubercular activity is detected by microplate alamar blue assay. Antimicrobial activity is tested by microdilution method. Results: All compounds obeyed the Lipinski’s rules, some of with no violation, some of with one violation. Compounds B7, B10 and B11 provided Lipinski’s rules with one violation. Other compounds ensured Lipinski’s rules with no violation. All compounds were predicted to have high gastrointestinal absorption. As the compounds generally have high lipophilicity, it was predicted that all compounds except B12 can cross the blood brain barrier. Conclusion: Synthesized compounds were mostly found to be more effective against Enterococcus faecalis, Enterococcus faecalis isolate and Candida albicans. Compound B10 demonstrated the best antimicrobial activity against Enterococcus faecalis isolate with a 16µg/mL MIC value.

The new pyrazoline derivative 5‐(3,4-Dimethoxy‐phenyl)‐3‐(2,5‐dimethyl‐thiophene‐3‐yl),‐4,5‐dihydro‐pyrazole‐1‐carbothioic acid amide (DDPA) as an advisable candidate for optical linearity, nonlinearity, and limiting performance

The present report provides the linear and nonlinear optical studies of a pyrazoline derivative, 5‐(3,4-Dimethoxy‐phenyl)‐3‐(2,5‐dimethyl‐thiophene‐3‐yl),‐4,5‐dihydro‐pyrazole‐1‐carbothioic acid amide (DDPA). The UV–Vis absorption and emission spectra have been recorded and analyzed to estimate the linear optical characteristics. The linear optical properties like absorption coefficient (α0), refractive index (n0), extinction coefficient (K), optical conductivity (σ opt), and optical band gap (Eg) have been evaluated. The third-order nonlinear optical (NLO) properties have been examined using the Z-scan technique employing the continuous wave (CW) diode laser of 520 nm. The third-order nonlinear refractive index (n2), nonlinear absorption coefficient (β), nonlinear optical susceptibility (χ (3)), and the second-order hyperpolarizability (γ) have been enumerated for different dye solution concentrations as well as for several laser powers. The values of β, n2, χ (3), and γ were found to be of the order of 10−3 cm/W, 10−7 cm2/W, 10−6 esu, and 10−26 esu respectively. Furthermore, the compound DDPA has been screened by the same laser excitation for the optical limiting behavior and found to be exhibiting good agreement for this nature. Hence the compound DDPA reveals its potential applications for optical switching, optical communication, and optical data storage devices.

Synthesis Characterization and Studying Antibacterial Activity of some New Pyrazol Derivatives

This research involved the conversion of sulfadiazine into compound 2-chloro-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide [A] through the reaction of sulfadiazine with chloroacetyl chloride in the presence of diethylamine in dimethylformamide as solvent. Then prepared the hydrazine derivative of sulfadiazine 2-hydrazinyl-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide [B] through the interaction of compound [A] with hydrazine in dimethylformamide as solvent. Followed by chalcones preparation [C1, C2, C3, C4, and C5] from the reaction of 4-aminoacetophenone with some aromatic aldehydes in a basic medium in absolute ethanol using an ice bath. Pyrazoline derivatives [BC1, BC2, BC3, BC4, and BC5] were prepared from the reaction of the hydrazine derivative of sulfadiazine [B] with chalcones in a basic medium in the presence of absolute ethanol. The pyrazole derivatives [IBC1, IBC2, IBC3, IBC4, and IBC5] were prepared from the reaction of the hydrazine derivative of sulfadiazine [B] with chalcones in the presence of glacial acetic acid and then the product was oxidized using Iodine. Synthesized compounds have been studied by their melting points, and characterized by C.H.N.S analysis, FT-IR and 1H-MNR spectroscopy and studied of biological activity.

Pyrazoline derivatives as tubulin polymerization inhibitors with one hit for Vascular Endothelial Growth Factor Receptor 2 inhibition

In this work, to check the effect of the transposition of the rings in typical patterns, a series of pyrazoline derivatives 3a-3t bearing the characteristic 3,4,5-trimethoxy phenyl and thiophene moieties were synthesized and evaluated as tubulin polymerization inhibitors. Basically, as the concise output of our design, a majority of the synthesized compounds showed potency in inhibiting the tubulin polymerization. The top hit, 3q, exhibited potent anti-proliferation activity on cancer cell lines. It was comparable on tubulin-polymerization inhibition with the positive control Colchicine but lower toxic. The VEGFR2 inhibitory potency was introduced occasionally. The flow cytometry assay confirmed the apoptotic procedure and the confocal imaging revealed the tubulin-microtubule dynamics pattern. The anti-cancer mechanism of 3q was similar to Colchicine but not exactly the same on forming multi-polar spindles. The docking simulation visualized the possible binding patterns of 3q into tubulin and VEGFR2, respectively. The results inferred that further investigations on the transposition of the rings might lead to the improvement of tubulin polymerization inhibitory activity and the steadily introduction of the VEGFR2 inhibition.

Design, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles

In a sustained search for novel and effective antioxidants, a potential therapeutic leads against renal, and neurological disorders. Amongst the heterocycles, pyrazole and their derivatives have been extensively studied for their biological potencies, particularly to a larger extent for their antioxidant properties. Although many of pyrazole derivatives displayed antioxidant activities, still there is a need of developing efficient protocol for their synthesis, involving ecofriendly conditions, molecules of greater antioxidant efficacy and lesser toxicity, etc. In this context, the current study presents an amberlyst-15 catalysed efficient synthesis of 2-pyrazoline derivatives, 5(a-g) via (3 + 2) annulation of chalcones with phenylhydrazines. Structure proofs of new pyrazoles offered by spectral studies, and the molecular structure of compound 5d of the series by crystallographic studies, which revealed an intra molecular hydrogen bond interactions (C–H⋯N type), and stabilization by C–H...π and π---π molecular interactions. Of the series, compounds 5g and 5h show excellent DPPH (IC50 = 0.245 ± 0.01, and 0.284 ± 0.02 μM); and hydroxyl (IC50 = 0.905 ± 0.01, and 0.892 ± 0.01μM) radical scavenging activities comparable with respective controls, ascorbic acid (IC50 = 0.483 ± 0.01μM) and BHA (IC50 = 1.739 ± 0.01μM). The molecular docking and ADME/Tox studies indicate that, these compounds have good antioxidant activity through π-π stacking with Catalase via Try337 and Phe140, and therefore, might be lead antioxidants for further study.

New Pyrazoline Derivatives Containing Imine Moiety: Synthesis, Characterization and Antimicrobial Study

A new series of pyrazoline derivatives (3-10) have been synthesized and characterized on the basis of FT-IR, 1H-NMR, and Mass techniques. 1-(4-Aminophenyl)-3-(pyridin-4-yl)prop-2-en-1-one (1) as a starting material was prepared by the reaction of 4-aminoacetophenone and 4-pyridinecarboxaldehyde in ethanol, using sodium hydroxide as a catalyst. Pyrazoline derivatives 2 was obtained via the cyclization reaction of compound 1 by the action of hydrazine hydrate 80% in ethanol. The target derivatives (3-8) were obtained by the reaction of pyrazoline derivative (2) with the corresponding aldehyde in ethanol. The novel pyrazoline derivatives 9 and 10 were synthesized by the reaction of pyrazoline derivative 2 with the corresponding anhydride (maleic or phthalic anhydride) in presence of anhydrous sodium acetate in glacial acetic acid. The synthesized derivatives were screened against several bacterial strains: Staphylococcus aureus, Staphylococcus espidermididis, Escherichia coli, Klebsiella and Candida albicans. The synthesized compounds showed promising bio-activity compared with amoxicillin.

Synthesis, Characterization, Cytotoxicity Study and Docking Studies of New Fused-pyrazoline Derivatives derived from Bis-Chalcones Against Breast Cancer cells

Breast cancer is one of the prevalent diseases that kill millions of women worldwide. The development of resistance and side effects of chemotherapy drugs is a common obstacle in the treatment of breast cancer. Recently, the focus of drug discovery has increased toward a valuable structure known as chalcones due to their extensive bioactivity in cancer treatment. In this study, 6 chalcones and 4 fused-pyrazoline derivatives have been synthesized (1-6) using the Claisen-Schmidt condensation technique for cyclopentanone and cyclohexanone with different aromatic aldehydes at room temperature. Chalcones 2-3 and 5-6 were used in cyclo-condensation reaction with thiosemicarbazide to form new fused pyrazoline derivatives. All the synthesized chalcones and fused pyrazoline were characterized using ATR-FTIR, H-NMR and 13C-NMR (1D ). The cytotoxic activity of these new chalcone compounds was investigated against breast cancer cell lines (MCF-7) and normal breast cell lines (MCF-10A). The results showed that compounds 1 and 10 exhibited significant antiproliferative effects against MCF-7 with IC50 values of 8 µM and 8.5 µM when exposed for 48 hours compared with the reference anticancer drug, tamoxifen. Molecular docking analysis showed that compounds 1 and 10 entered the pocket of ERα and interaction with the amino acids in high affinity of binding as tamoxifen.

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents.

The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished via the condensation of the appropriate substituted aldehydes and acetophenones, suitable chalcones and hydrazine hydrate in absolute ethanol in the presence of drops of glacial acetic acid. The compounds are obtained in good yields 68–99% and their structure was confirmed using IR, 1H-NMR, 13C-NMR and elemental analysis. The novel derivatives were studied in vitro for their antioxidant, anti-lipid peroxidation (AAPH) activities and inhibitory activity of lipoxygenase. Both classes strongly inhibit lipid peroxidation. Compound 2g was the most potent lipoxygenase inhibitor (IC50 = 80 µM). The inhibition of the carrageenin-induced paw edema (CPE) and nociception was also determined, with compounds 2d and 2e being the most potent. Compound 2e inhibited nociception higher than 2d. Pyrazoline 2d was found to be active in a preliminary test, for the investigation of anti-adjuvant-induced disease (AID) activity. Pyrazoline derivatives were found to be more potent than pyrazoles. Docking studies of the most potent LOX inhibitor 2g highlight hydrophobic interactions with VAL126, PHE143, VAL520 and LYS526 and a halogen bond between the chlorine atom and ARG182.

SYNTHESIS AND ANTIOXIDANT ACTIVITIES OF SOME 1N-ACETYL-3-(3- HYDROXYPHENYL)-5-(SUBSTITUTED PHENYL)-4, 5-DIHYDRO1H-PYRAZOLINES

By Ganesamoorthy Thirunarayanan. A series containing sixteen titled pyrazoline derivatives have been synthesized by perchloric acid catalyzed cyclization cum acetylation of 3-hydroxyphenyl chalcones, hydrazine hydrate and acetic anhydride by refluxing condition.

Synthesis, Antidiabetic Evaluation and Bioisosteric Modification of Quinoline Incorporated 2-pyrazoline Derivatives

Synthesis, Antidiabetic Evaluation and Bioisosteric Modification of Quinoline Incorporated 2-pyrazoline Derivatives

Novel coumarin-based pyrazoline derivatives organogels for Fe3+ detection and application in cell imaging

Two novel coumarin-based pyrazoline derivatives have been designed and synthesized as organogel factors. Organogelators Z 1–2 both have gelation behavior in alcohol solution and DMSO. Gel- tert -butanol Z 1–2 (CGC = 1.84%, 1.41%) fluoresce blue and yellow-green under ultraviolet irradiation, respectively. Z 1–2 both exhibit selectivity for response to Fe 3+ in THF-deionized aqueous (V: V = 9:1) solution, meanwhile display high sensitivity. Notably, introducing diethylamino at 7-position the coumarin unit increases the detection line range in Z 2 . Furthermore, Z 2 not only has a good biocompatibility in living cells but also the sensing behavior of Fe 3+ in the cell nucleus. The coordination mechanism of gelators Z 1–2 and Fe 3+ were performed at the DFT level. • Two novel coumarin-based pyrazoline organogelators Z 1–2 have designed and synthesized. • The Z 1–2 can both form fluoresce organogels in tert-butanol (CGC=1.84%, 1.41%). • The Z 1–2 can both response to Fe 3+ in aqueous solution and organogels with selectivity and sensitivity. • The Z 2 can detect Fe 3+ in living cells.

Synthesis, characterization, single crystal XRD, Hirshfeld surfaces, 3D energy framework calculations and DFT studies of ethanone and propanone derivatives of N-substituted pyrazolines

The spectroscopic and single crystal X-ray diffraction characteristic of ethanone and propanone derivatives of pyrazolines derived from (2E)-3-(Anthracen-9-yl)-1-(thiophen-2-yl) prop‑2-en-1-one have been discussed. Using the computational techniques, Hirshfeld surfaces analysis was carried to reveal the intermolecular interactions contribution. The two-dimensional fingerprint plots and electrostatic potential were generated as evidence to the intermolecular interactions. Whereas topology surfaces; shape index and curvedness were examined to conclude the π⋯π stacking interactions associated with atoms and 3D energy framework calculations results were estimated that intermolecular interaction energies and topologies of the pair-wise fragments. Using the density functional theory (DFT) studies, structural, electronic and photo-physical properties of the two synthesized organic molecules were evaluated.

Synthesis and Activity Evaluation of Some Pyrazole–Pyrazoline Derivatives as Dual Anti-Inflammatory and Antimicrobial Agents

In this study, 18 pyrazole derivatives coupled with pyrazoline were synthesized and screened for their anti-inflammatory and antimicrobial activities. All the target compounds were synthesized smoothly and characterized using 1H NMR, 13C NMR, and HRMS. In vitro lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α model and in vivo xylene-induced ear-edema model were used to evaluate their anti-inflammatory activity. Antimicrobial activity against several Gram-positive strains and Gram-negative strains was evaluated using a serial dilution method. Pharmacological results indicated that most of the compounds markedly inhibited the expression of TNF-α at the concentration of 20 μg/mL. Compounds 9b showed 66.4% inhibition for the LPS-induced TNF-α release, which was superior than that of the positive control drug dexamethasone (DXMS). And compounds 4a, 4b, 5a, 5b, 6b, and 9b showed comparable inhibition activity to DXMS. In xylene-induced ear-edema model, compound 4a inhibited edema by 48.71%, which was more effective than DXMS (47.18%) in inhibiting xylene-induced ear edema. Compound 4b, 5a, 5b, 6b, and 9b showed inhibition of 36.82%, 27.65%, 45.87%, 31.78%, and 43.67%, respectively. Furthermore, compounds 4a, 5a, 5b, and 9b displayed broad-spectrum antimicrobial activity against several Gram-positive and Gram-negative bacterial. These compounds, 4a, 5a, 5b, and 9b, possess both anti-inflammatory and antimicrobial activities, thus are worth further investigation to enhance their antimicrobial activities for the development of new class of dual anti-inflammatory–antimicrobial agents.

Molecular docking , Synthesis and ADME Studies of New Pyrazoline Derivatives as Potential Anticancer Agents.

ABSTRACT Cancer is a significant worldwide public health issue.The adverse effects of anticancer chemotherapies still compromise the quality of life of patients .To identify new potential targeted anticancer agents, a series of pyrazoline derivatives were synthesized and evaluated for anticancer effects on A549 (human lung adenocarcenoma cell line). The new derivatives were synthesized by incorporating pyrazoline pharmacophore into nabumetone moiety as a starting molecule and the chalcone derivatives as intermediate products. In silico evaluation methods were done before synthesis through .molecular docking via genetic optimization for ligand docking (GOLD) Suite software with EGFR tyrosine kinase and exhibited significant tyrosine kinase inhibition activities compared with erlotinb as a reference drug due to their hydrogen bonding interaction with key amino acids and these results are compatible with the experimental findings . The Compound structures were confirmed by 1H-NMR , some physicochemical properties and infrared spectroscopy . An in vitro assay demonstrated that the final compounds (P1,P2,P3 and P4) exerted potent to moderate cytotoxic activity in the micromolar range with an IC50 values (15.409µM, 7.24µM, 27.05µM, 22.45µM) respectively when compared with erlotinib (IC50 =25.23µM) while (P5&P6) show weak activity . Pharmacokinetic and physicochemical properties of the final compounds predicted by using ADME Evaluations . The results showed all the synthesized compounds have high oral bioavailability and good GI absorption.

Synthesis, Characterization and Biological Evaluation of New 3,5-Disubstituted-Pyrazoline Derivatives as Potential Anti-Mycobacterium tuberculosis H37Ra Compounds.

A total of fourteen pyrazoline derivatives were synthesized through cyclo-condensation reactions by chalcone derivatives with different types of semicarbazide. These compounds were characterized by IR, 1D-NMR (1H, 13C and Distortionless Enhancement by Polarization Transfer - DEPT-135) and 2D-NMR (COSY, HSQC and HMBC) as well as mass spectroscopy analysis (HRMS). The synthesized compounds were tested for their antituberculosis activity against Mycobacterium tuberculosis H37Ra in vitro. Based on this activity, compound 4a showed the most potent inhibitory activity, with a minimum inhibitory concentration (MIC) value of 17 μM. In addition, six other synthesized compounds, 5a and 5c–5g, exhibited moderate activity, with MIC ranges between 60 μM to 140 μM. Compound 4a showed good bactericidal activity with a minimum bactericidal concentration (MBC) value of 34 μM against Mycobacterium tuberculosis H37Ra. Molecular docking studies for compound 4a on alpha-sterol demethylase was done to understand and explore ligand–receptor interactions, and to hypothesize potential refinements for the compound.

An Efficient Suitable Synthesis for Pyrazole, Pyrimidine Derivatives and Biological Evaluation

Novel quinazoline derivatives were synthesized by reacting isatoic anhydride and 4-amino acetanilide to synthesize N-(4-(2,4-dioxo-1,2- dihydroquinazolin-3(4H)-yl)phenyl)acetamide which in turn reacted with substituted aromatic aldehydes to synthesize novel chalcones. The chalcones were allowed to react with hydrazine hydrochloride and guanidine to form pyrazoline and pyrimidine derivatives, respectively. The newly synthesized compounds were characterized by IR, NMR (1H, 13C), mass and elemental analysis. All the newly synthesized derivatives were screened for in vitro antimicrobial and antioxidant activities to evaluate their biological potency.

Multifunctional Aspects of the Synthesized Pyrazoline Derivatives for AP1 5L X60 Steel Protection Against MIC and Acidization: Electrochemical, In Silico, and SRB Insights.

The inhibitory impact of low-cost synthesized pyrazoline derivatives named Pz series (Pz1 and Pz2) on the corrosion of API 5L X60 carbon steel in 5 M HCl was inspected to serve as corrosion inhibitors against such a solution for its usage in the oilfield well acidization process. Also, the same compounds were unitized as biocides for sulfate-reducing bacteria (SRBs) to inhibit the microbial-induced corrosion effect. This study was conducted via several electrochemical techniques, namely, electrochemical potentiodynamic polarization (EP) and electrochemical impedance spectroscopy (EIS), in addition to computational density functional theory (DFT). The inhibition efficiency (IE) of Pz series on the corrosion of 5L X60 carbon steel in 5 M HCl was found to increase whenever the Pz series molecule concentration was increased. EP measurements revealed that Pz1 and Pz2 have both cathodic and anodic features (mixed inhibitor) and their corrosion IEs were around 90%. The physicochemical properties of the Pz1 and Pz2 compounds were studied using Langmuir adsorption isotherms, where the equilibrium adsorption data were found to follow it accurately. EIS outputs were found to comply with the values obtained from EP. Scanning electron microscopy was used to examine the topographic anisotropy between the inhibited and uninhibited 5L X60 carbon steel samples to double-check the electrochemical findings. DFT calculations and Monte Carlo simulations were utilized to predict the behavior of inhibitors and to rationalize the experimental results. The serial dilution bioassay technique was used to assess the Pz series as potential biocides to counter the effect of SRBs in compliance with the TM0194-2014-SG standard test method, and the results showed the potency of Pz series in inhibiting such bacterial growth.

Ionic Liquid-Coated Nanoparticles (CaO@SiO2@BAIL): A Bi-Functional and Environmentally Benign Catalyst for Green Synthesis of Pyridine, Pyrimidine, and Pyrazoline Derivatives

A novel ionic liquid-coated nanomaterials (CaO@SiO2@BAIL) was successfully synthesized by anchoring the 1-(3-(trimethoxysilyl)propyl)-1,3,5,7-tetraazaadamantan-1-ium chlorozincate (II) bi-functional ionic liquid (BAIL) onto the surface of silica‐coated CaO nanoparticles. The structure of catalyst was characterized using various analytical techniques such as Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), WDS map scan, thermogravimetric (TGA), and inductively-coupled plasma-mass spectrometry (ICP-MS). The performances of prepared hybrid nanomaterial (CaO@SiO2@BAIL) as a catalyst were evaluated for the efficient synthesis of the pharmaceutically valuable heterocyclic compounds. A variety of pyridine, pyrimidine, and pyrazoline derivatives were synthesized in the presence of CaO@SiO2@BAIL within green conditions. The presented method has several advantages such as high yields, low reaction times, and easy preparation of the catalyst. The bi-functional heterogeneous nanocatalyst can be reused at least six times without considerable loss of its catalytic activity.