This paper reports work studying the partial substitution of the commonly used plasticiser di-octyl phtalate (DOP) by the permanent plasticisers ethylene-vinyl-acetate (EVA) and acrylonitrile-butadiene-styrene (ABS) in order to reduce migration of additives initially present in poly(vinyl chloride) (PVC) stabilised with epoxidised sunflower oil (ESO). Various formulations with and without the two different permanent plasticisers were prepared. Their tensile properties were compared. Migration tests with agitation at 40°C in two food simulants (olive oil and 15% aqueous ethanol) were carried out. The mass variation of the PVC samples with time was investigated. Migration phenomena were studied by using various analytical methods such as Fourier transform infrared spectroscopy (FTIR), atomic absorption spectrometry (AAS) and scanning electron microscopy (SEM). The results showed that additives migration can be considerably reduced by partial substitution of DOP with both permanent plasticisers used. The best results were obtained with the binary system of plasticisers based on DOP:ABS (30:10).