The new millennium has witnessed a pervasive shift of trend from AC to DC in the residential load sector. The shift is predominantly due to independent residential solar PV systems at rooftops and escalating electronic loads with better energy saving potential integrated with diminishing prices as well as commercial availability of DC-based appliances. Comprehensive sensitivity analysis considering the real load profile is missing in the present body of knowledge. In order to fill that gap, this paper is an attempt to include a comprehensive sensitivity analysis of the DC distribution system and its simulation-based comparison with its AC counterpart, considering the real load profile. The paper uses the Monte Carlo technique and probabilistic approach to add diversity in residential loads consumption to obtain an instantaneous load profile. Various possible scenarios such as variation of standard deviation from 5% to 20% of mean load value, PV capacity variation from 1000 W to 9000 W, and variation in power electronic converter (PEC) efficiencies are incorporated to make the system realistic as much as possible maintaining a fair comparison between both systems. The paper concludes with the baseline efficiency advantage of 2% to 3% during the day for the case of the DC distribution system as compared to the AC distribution system.