Pustular Dermatosis Research Articles

Subcorneal Pustular Dermatosis Successfully Treated with Acitretin in a Patient with Glucose-6-Phoshate Dehydrogenase Deficiency

Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis. SPD most commonly presents as a serpiginous pattern of pustules on the trunk or intertriginous areas of middle-aged females. It tends to have a chronic disease course and patients may experience relapses. Dapsone currently remains the treatment of choice for SPD. However, in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, alternative therapies are required. We report a case of subcorneal pustular dermatosis in a G6PD deficient patient successfully treated with acitretin.

Treatment of erosive pustular dermatosis: a systematic review of the literature.

Erosive pustular dermatosis (EPD) is a rare chronic inflammatory condition of the scalp and legs that is often difficult to manage. Currently, there are no treatment guidelines. To systematically assess the existing literature on various treatment modalities and their efficacies when used in the management of EPD. We searched PubMed, Cochrane Libraries, Scopus, and clicnialtrial.gov databases for articles in the English language with no limited time frame. Emphasis was placed on articles that reported on treatment for EPD. Of the 168 articles identified by the literature search, 92 met eligibility criteria and were included for qualitative analysis. Efficacious topical treatments included clobetasol, betamethasone, and tacrolimus. Ninety-three and 88% of cases utilizing clobetasol and betamethasone respectively demonstrated improvement or resolution. All 32 cases utilizing tacrolimus reported improvement. Efficacious systemic treatments included oral steroids such as prednisone, methylprednisolone, and dexamethasone. Topical dapsone, photodynamic therapy, systemic steroids, cyclosporine, and oral zinc derivatives were also described with some success. According to available data, limited solely to case reports and case series, potent topical steroids are an effective treatment option for EPD. Topical tacrolimus may also be considered in cases that require long-term use or maintenance. Other treatment modalities shown to be successful based on high reported efficacy and low rates of recurrence after treatment include topical dapsone, systemic steroids, zinc derivatives, and cyclosporine. Further studies are needed to compare treatment modalities and to establish treatment protocols.

Erosive Pustular Dermatosis of the Scalp After Excision and Skin Grafting of Scalp Squamous Cell Carcinoma

Abstract Introduction: Erosive pustular dermatosis of the scalp (EPDS) is an uncommon condition with unknown etiology. The clinical exclusive diagnosis needs to be differentiated from similar diseases. Here, we present a case of EPDS after surgical treatment of scalp squamous cell carcinoma. Case presentation: A 68-year-old woman presented with an eight-month history of a chronic scalp eruption. She had been diagnosed as squamous cell carcinoma by biopsy nine months ago, and had been treated by surgical excision and skin grafting. One month later, she was referred for evaluation of the newly enlarged lesion which was observed at the skin grafting site. She was diagnosed of EPDS based on characteristics of lesions, clinicopathological findings and laboratory data. The condition had clinically improved with systemic steroid therapy and topical tacrolimus for two weeks. Relapses occurred after complete withdrawal of both treatments. After repeating the above therapy and applying topical tacrolimus as maintenance therapy, the condition was well controlled at the one-year follow-up. Discussion: EPDS is an uncommon inflammatory dermatosis with main incidence rate of elderly patients and female predominance. The diagnosis of EPDS cant be made only by histopathological examination, which is helpful for differential diagnosis. Microbiological investigations commonly remain negative. For the high risk of relapse, it is important for clinicians to be aware of maintenance treatment and a long- term management. Conclusion: It should be recognized by clinicians that EPDS is an uncommon and relapse disease, leading to serious cosmetic problems. The treatment lacks evidence-based medicine data, clinician should choose the appropriate therapy according to the condition of patients.

Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Disease): A Rare Case

Subcorneal pustular dermatosis (SPD) is a rare, chronic, recurrent, pustular eruption. It may be difficult to differentiate SPD from Acute Generalized Exanthematous Pustulosis (AGEP) and Generalized Pustular Psoriasis (GPP)just from clinical appeareance. A 48 years old woman with subcorneal pustular dermatosis was reported. She was complained there were tiny blisters containing pus on the reddish patches that felt burning and became widespread to neck, chest, abdomen, arms, groin and legs since 4 days ago. Patient had no history of skin lesion before. From physical examination revealed no other pathologies and on the skin showed erythematous patches with annular lesion, pustules formation that tended to coalesce to form desquamative plaques, erosions, on chest, abdomen, back, arm, buttock and leg. Based on histopathology showed there are subcorneal pustules. The subcorneal pustule is filled with neutrophils and on the dermis, there are mild infiltration of neutrophil cells. This feature revealed to SPD.Clinically it may be difficult to differentiate SPD from AGEP and GPP. Histopathology examination can distinguished these disease,patient was treated with prednisone 40 mg and dapson 100 mg and had improvement after 4 weeks.

A case of tinea incognito mimicking subcorneal pustular dermatosis

An 89-year-old woman presented with plaque-like lesions, accompanied with pustules and desquamation on the back and front of the trunk for approximately one year. Long term use of potent topical corticosteroids was ineffective. Because of the chronicity of her condition, the diagnoses of subcorneal dermatosis or subcorneal pustular dermatosis type of IgA pemphigus were considered. However, fungal hyphae were observed in the potassium hydroxide examination. Therefore, we present this case since this clinical appearance of tinea incognito can also mimic various pustular dermatoses.

Erosive pustular dermatosis of the scalp following surgical procedures: a systematic review

Erosive pustular dermatosis of the scalp (EPDS) occurs in elderly individuals with significant actinic damage. EPDS also occurs in association with surgery; however, significant studies determining an association of EPDS with type of surgical closure is absent. This review examines whether the closure method following cutaneous surgery performed on the scalp is associated with development of EPDS. Databases were reviewed and studies describing EPDS after cutaneous surgery met inclusion criteria. Articles were excluded if EPDS developed after trauma or non-surgical procedures. Descriptive analyses were performed on the data. Thirteen case reports and 6 case series involving 32 patients met inclusion criteria. Fourteen articles (73.7%) stated that EPDS developed in the same location as, or near to, the closure site. Thirteen patients (40.6%) developed EPDS following skin grafting. Three patients (9.4%) developed EPDS following secondary intention healing, two patients (6.3%) following repair by primary intention, and one patient (3.1%) following repair with a local skin flap. Thirteen cases (40.6%) did not specify closure type. This review revealed that surgical procedures performed on the scalp utilizing skin grafts for closure may be increasingly associated with the development of EPDS compared to other closure types.

Podrogowa dermatoza krostkowa skutecznie leczona acytretyną

Podrogowa dermatoza krostkowa skutecznie leczona acytretyną

A case of suspected subcorneal pustular dermatosis in a French bulldog

A case of suspected subcorneal pustular dermatosis in a French bulldog

Subcorneal pustular dermatosis: An unusual presentation in pediatric age group

Subcorneal pustular dermatosis (SPD), first described by Sneddon and Wilkinson, represents a rare chronic and relapsing sterile pustular eruptions generally involving the trunk and flexor aspect of limbs. Usually, it affects middle-aged or elderly women. Histologically, it is characterized by the accumulation of subcorneal neutrophils with an absence of spongiosis and acantholysis. Here, we are reporting a rare case of SPD in the pediatric age group, which was diagnosed based on clinical and histological findings. We gave dapsone in treatment with a positive outcome. To the best of our knowledge, there has not been any case report in the pediatric age group from India so far.

Erosive pustular dermatosis of the scalp

Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory condition commonly associated with antecedent iatrogenic insult. EPDS may be diagnostically challenging owing to a lack of pathognomonic histologic findings and cutaneous manifestations that overlap with alternative dermatologic conditions. Therefore, EPDS may be more common than previously recognized. We present a 60-year-old woman with a four-year history of non-healing scalp erosions, progressive skin atrophy, and scarring alopecia despite intravenous antibiotics and intraoperative debridement who improved with systemic glucocorticoids. Our report emphasizes the importance of early recognition of EPDS when delayed wound healing and erosive disease occur in the setting of iatrogenic injury to the scalp. Timely treatment with systemic anti-inflammatory agents is paramount to prevent cicatricial alopecia and mitigate further scalp insult in EPDS.

The Striking Appearance of a Rare Skin Condition: “Half-Half” Blisters (Subcorneal Pustular Dermatosis)

The Striking Appearance of a Rare Skin Condition: “Half-Half” Blisters (Subcorneal Pustular Dermatosis)

The role of mixed Mycoplasma and Herpesvirus infections in case of skin lesions in children

Numerous literature data show the role of mycoplasma infection in the development of non-respiratory lesions of various organs and systems, including the skin. Herpesvirus and mycoplasma infections can trigger the development of immune-mediated inflammatory reactions of the skin and mucous membranes — erythema multiforme exudative, Stevens-Johnson syndrome, vesicular pustular dermatosis — Sneddon-Wilkinson syndrome, etc.In order to study the frequency and nature of skin lesions with mycoplasmosis combined with herpesvirus infection, 45 patients aged 3 to 15 years of life were observed. A comprehensive clinical and laboratory study revealed skin lesions in 27 patients associated with current mycoplasma and herpesvirus infections. Thus, multiforme exudative erythema in the small form variant was diagnosed in 13 patients, skin vasculitis in 4, hemorrhagic purpura in 3, urticaria rash in 3, erythema nodosum in 2, mucositis in 2 children. In 18 children, a combined mycoplasma and herpesvirus infection was established. In 9 children, a mono infection was detected (in 5 — herpes virus and in 4 — mycoplasma).All observed patients showed antibodies to smooth muscle antigens in titers from 1:80 to 1:160 (normal 1:40) and in the vast majority (in 24 patients) — antibodies to vascular endothelial antigens in titers from 1:80 to 1:320 (with the norm of 1:40). Compaction of the intima-media complex was detected in 6 patients with monoinfection and in 16 patients with co-infection, according to ultrasound duplex scanning of the vessels of the brachiocephalic department.Thus, for various immuno-inflammatory, allergic skin diseases, screening for infections, in particular, mycoplasma and herpesvirus, is necessary to optimize treatment.

Erosive pustular dermatosis of the scalp: challenges and solutions.

Erosive pustular dermatosis of the scalp is a rare chronic inflammatory disorder defined. It usually affects elderly people and is characterized by extensive pustular lesions, erosions, and crusts located on the scalp. The pathogenesis of this disease is not completely understood, but a known predisposing factor is skin trauma. Autoimmune disorders including rheumatoid arthritis, autoimmune hepatitis, Hashimoto thyroiditis, and Takayasu aortitis are associated diseases reported. The clinical examination reveals erythema, erosions, crusts, follicular pustules, and in advanced stages, scarring alopecia. A scalp biopsy is recommended but not specific, founding epidermal atrophy, focal erosions, and a mixed inflammatory infiltrate consisting of neutrophils, lymphocytes, and plasma cells. Bacterial cultures, fungal and viral stains are not necessary and are usually negative. . Topical high-potency corticosteroids, retinoids, calcipotriol, dapsone, and topical tacrolimus are reported treatments, while photodynamic therapy has been effective in some patients, but has induced the disease in others. All the findings are suggestive but not specific, so it is an excluding diagnosis. The combination of predisposing factors is very important for a correct diagnosis, such as elderly age, sun-damaged skin, presence of androgenetic alopecia, together with clinical manifestations, non-specific histology and laboratory investigations negative for other disease. In our opinion, this scalp disease is a challenge for the dermatologist. We review all the literature to better define the possible solutions in case of suspected erosive pustular dermatosis of the scalp.

Treatment of erosive pustular dermatosis: A review of the literature

Treatment of erosive pustular dermatosis: A review of the literature

Erosive pustular dermatosis of the scalp: A successful treatment with oral tofacitinib

Erosive pustular dermatosis of the scalp: A successful treatment with oral tofacitinib

Erosive pustular dermatosis: An unusual and severe case

Erosive pustular dermatosis: An unusual and severe case

Subcorneal pustular dermatosis treated with oral dapsone

Subcorneal pustular dermatosis treated with oral dapsone

Erosive pustular dermatosis as a cause of delayed burn wound healing: A case report

Erosive pustular dermatosis as a cause of delayed burn wound healing: A case report

Deficiency of Interleukin-1 Receptor Antagonist: A Case with Late Onset Severe Inflammatory Arthritis, Nail Psoriasis with Onychomycosis and Well Responsive to Adalimumab Therapy

DIRA (deficiency of the IL-1Ra) is a rare condition that usually presents in the neonatal period. Patients with DIRA present with systemic inflammation, respiratory distress, joint swelling, pustular rash, multifocal osteomyelitis, and periostitis. Previously, we reported a patient with a novel mutation in IL1RN with a healthy neonatal period, a late-onset of pustular dermatosis, inflammatory arthritis, and excellent response to canakinumab treatment. Herein, we are presenting a new case of late-onset DIRA syndrome, carrying a different mutation and showing different clinical findings. This patient is the first one in the literature with the inflammatory arthritis, nail psoriasis, and onychomycosis and with her remarkable response to monoclonal antibodies. The case responded well and fully recovered after treatment with adalimumab, but not with canakinumab. The DIRA disease can lead to death from multiple organ failures and if recognized early, the treatment with replacement of the deficient protein with biologic agents induces rapid and complete remission. Therefore, clinical symptoms should be learned exactly by the pediatricians, pediatric rheumatologists, and immunologists; and molecular analysis targeting this defect must be performed as early as possible.

Probable drug-triggered pemphigus foliaceus in a dog following administration of afoxolaner (NexGard)

A nine-year-old castrated male miniature dachshund presented for chronic pustular dermatitis, lethargy, fever and weight loss. There was no history of dermatological disease prior to lesion development which occurred within...