The nonlinear static procedure, based on pushover analysis, has become an important tool to characterize the seismic demand and the performance of structures. The standard pushover procedure is restricted to single-mode response, a valid supposition for symmetrical or low-rise buildings, where the response is dominated by the fundamental vibration mode. The standard pushover procedures become misleading when the response of the structure is influenced by higher vibration modes. This is the case of tall or non-symmetrical buildings. Several pushover procedures, able to take into account the effects of higher vibration modes, have been lately developed to overcome this drawback. This paper presents a comparison between standard, advanced pushover analyses and the exact results obtained by nonlinear time history analysis. The analyses have been conducted on a series of moment-resisting steel frames with stiffness irregularities, with different number of stories, designed according to EC8 and the Romanian Seismic Design Code for Romania's Vrancea Seismic Area.