Push Effect Research Articles

Abstract 4269: Effect of PAX3-FOXO1 fusion gene on cell-extracellular matrix interaction of Rhabdomyosarcoma

Abstract Background Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma, categorized by two subtypes, fusion protein-positive (FPRMS) and negative (FNRMS), based on the existence of PAX3-FOXO1 fusion gene (P3F). Different features between the two subtypes could guide the use of distinct treatment approaches. We discovered that FNRMS exhibited enrichment of gene sets related to cell-extracellular matrix (ECM) interaction than FPRMS. ECM, providing physical support as a scaffold, regulates cancer development. We hypothesize that a distinct molecular feature, P3F, may cause the difference in cell-ECM interaction between FPRMS and FNRMS. Methods To confirm the higher cell-ECM interaction of FNRMS vs. FPRMS, we used confocal reflection microscopy (CRM), enabling us to monitor the fibrous structures of ECM. We generated the spheroids with FNRMS and FPRMS cell lines by hanging drop method and embedded them into collagen type I. Then, we assessed orientation and dynamic changes in the structure of collagen fibers surrounding spheroids. Also, we analyze the transcriptome of FPRMS cells with P3F knockdown to confirm if P3F regulates cell-ECM interaction negatively via RNA seq. Additionally, we examined ECM surrounding spheroids of P3F knockdown FPRMS cells if P3F modulates fibrous structures of ECM, indicating cell-ECM interaction. Results We showed that collagen fibers are oriented more perpendicular to the FNRMS spheroid surface, indicating the strong pulling and pushing effect of cells. However, fibers surrounding FPRMS spheroids showed parallel alignment to their surfaces, reflecting passively pushed by the spheroids. Additionally, fibers near FNRMS spheroids showed greater displacement than those near FNRMS spheroids, which suggests stronger cell-ECM interaction in FNRMS than in FPRMS. Furthermore, P3F knockdown FPRMS cells exhibited significant enrichment of gene sets related to cell-ECM interaction. Their CRM results showed that collagen fiber orientation was significantly perpendicular to the surfaces of spheroids of P3F knockdown FPRMS cells than those of control cells. P3F knockdown cell spheroids also displayed enhanced displacement of ECM fibers than control cells. These results suggest that P3F suppresses cell-ECM interaction, consistent with higher cell-ECM interaction of FNRMS than FPRMS. Conclusions The PAX3-FOXO1 gene may regulate cell-ECM interaction negatively, causing distinct features between FPRMS and FNRMS, which is crucial for various cellular functions and suggest different treatment between the two RMS subtypes. Citation Format: Chandra Kaladhar Vemula, Ivan Chavez, Anthony Chronopoulos, Jinseok Park. Effect of PAX3-FOXO1 fusion gene on cell-extracellular matrix interaction of Rhabdomyosarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4269.

Factors Influencing Customer Switching Intentions in Online Food Delivery: A Perspective of The Push-Pull-Mooring Model

The online food delivery applications born in the digital era have transformed the habits of users in meeting their needs through these platforms. With the convenience of ordering various cuisines from the comfort of their homes, customers experience significant time and energy savings. In this context, service providers must deliver acceptable service quality; otherwise, customers will swiftly switch to competitors offering better value. This research aims to identify the driving, pulling, and anchoring effects on the intention of customers to switch between online food delivery services, utilizing the Push-Pull-Mooring framework to evaluate the relationships between variables. The study employed Structural Equation Modeling of the Partial Least Squares (SEM-PLS) type. The research findings indicate that push effects and pull effects have a positive influence on switching intention, while mooring effects do not positively impact switching intention. Furthermore, the study reveals that mooring effects do not moderate the relationship between push effects, pull effects, and switching intention. These evaluation results can serve as guidance for online food delivery companies, assisting them in enhancing their services to build strong relationships with existing customers and attract new ones.

Mediating Role of Pluriactivity in the Relationship Between Rural Entrepreneurship Ecosystem and Income Doubling in Nigeria's Bauchi State

ABSTRACT: The majority of rural households in emerging nations are currently diversifying their sources of income. Rural income diversification focuses primarily on improving the use of the currently available production resources and boosting household income, as opposed to investment portfolios in finance that diversify to reduce risks. Despite substantial discussion of the causes or impacts of rural income pluriactivity, there are no well-established standards for the use of indicators to record actual rural income diversification in the existing literature of the study area. Therefore, in lieu of the foregoing, attempt was made to assess the mediating role of pluriactivity in the relationship between rural entrepreneurship ecosystem and income doubling in Nigeria's Bauchi state using cross-sectional data elicited by a well-structured questionnaire coupled with interview schedule from 322 households selected via a multi-stage random sampling technique. With the aid of descriptive and inferential statistics, the study objectives were achieved. The inferential statistics encompass diversification index viz. Entropy index, Herfindahl-Hirschman index, Berry's index, and, Ginevičius index; decision regression model; and, confirmatory factor analysis. Empirically, the findings established that pluriactivity was high among most of the households and it was majorly driven by educational level. Besides, pluriactivity is established to enhance incomes of low-to-medium income levels households while it imposes a progressive declining effect on the income of households with high income level. Nevertheless, operational holding was the kick-starting impetus that derived pluriactivity of the rural economy. Furthermore, economic factor, a push effect that motivates rural entrepreneurship, has strong influence that will enhance pluriactivity capacity to double rural households' income in the long-run. Therefore, for a flourishing rural entrepreneurship that will drive sustainable growth and development of rural economy in the study area, the study suggests that households should see pluriactivity as a business entity independent of a household against the old norms that view both as just a single entity. As a rider, onus lies on policymakers to harp more on out of class education as a measure to enhance the risk bearing ability of the rural populace, thus mitigation to the posed challenges of weather-induced vagaries threatening livelihood in the study area.

Farmers’ Perceptions of Maize Production Constraints and the Effects of Push–Pull Technology on Soil Fertility, Pest Infestation, and Maize Yield in Southwest Ethiopia

This study aimed to analyze farmers’ perceptions of maize production constraints and determine the effects of push–pull technology (PPT) on crop yield, pest control, and improving soil fertility status. Increasing fertilizer prices and pesticide prices, FAWs (fall armyworms) and stemborers, declining soil fertility, and drought are the main maize production constraints in the area. Seventy percent of the respondents indicated that an increase in input prices such as those of fertilizer and seeds is the major constraint in the area, while FAWs (55%) and stemborers (44.3%) were ranked the third and fourth major constraints. About 67% of farmers reported that stemborer damage to maize in PPT plots was either minimal or non-existent. Fifty-five percent of farmers stated that the damage caused to maize by FAWs was low or that there was no damage in PPT plots. PPT reduced stem borer infestation from 83% to 44%. The yield gained from PPT plots ranged from 18% to 31%. Soil samples taken from PPT plots showed improved soil organic carbon, organic matter, total nitrogen, and cation exchange capacity.

Catalysing Sustainability: Exploring Factors Shaping Green Initiatives in Micro, Small, and Medium-Sized Enterprises

By applying the PLS-SEM method to survey the data of 350 samples in Indonesia, this paper develops a framework based on three potential elements: push effect (partnership and cooperation, rules and regulations, value practices), pull effect (government support, market sophistication, environmental awareness), and mooring effect (technological support and switching costs) about the transition of micro, small, and medium enterprises (MSMEs) towards green practices. The study reveals that these factors exhibit variations in terms of statistical significance. The findings indicate that an increase in the push effect and pull effect significantly influences the switching behaviour of MSME owners/managers. In contrast, concerning the mooring effect, each element demonstrates varying levels of direct influence on the transition towards green practices in MSMEs, with some impacts proving to be statistically significant and others not. Overall, these findings shed light on the intricate dynamics of MSMEs environmental responsibility, offering valuable insights for policymakers and practitioners.

Analysis of Switching Behavior for Using Digital Payment Financial Technology in Tumenggungan Market Kebumen, Central Java

This study aims to determine the factors and switching behavior of using cash payment services to digital payment services in Tumenggungan traditional market Kebumen, Central Java Province, Indonesia. This study uses primary data with as many as 175 respondents through purposive sampling. The switching behavior is estimated by using the push-pull-mooring (PPM) framework method by using structural equation modeling (SEM) - Partial Least Square (PLS). The results show that the push effect (high price perception, security risk, privacy risk) and the mooring effect (reputation, inertia, switching cost) positively and significantly affect the switching behavior. While pull effects (ease of use, relative advantage, relative ease of processing) have a positive impact but are not significant to the potential for switching behavior. In short, visitors to the Tumenggungan market feel satisfied with cash payments. They are less motivated to use digital payment. Still, the visitors do not create resistance to making a change. The results indicate that the visitors of the Tumenggungan market view digital payment as a complementary instrument, not substitution, which means visitors accept either cash or digital payment in their transaction settlements. These findings are significant in further promoting technological literacy among people by organizing many trainings and seminars so that people are rational when switching behavior between cash and digital payments.

Effect of occupational pushing and pulling combined with improper working posture on low back pain among workers.

This study aimed to investigate the impact of occupational pushing and pulling combined with improper working posture on work-related low back pain (LBP) among workers. A web-based survey was conducted in 2022 to collect data from 15,623 workers, who were categorized into proper and improper working posture groups. Multiple logistic regression analysis was used to analyze the association between pushing and pulling loads and LBP in each group. In the proper working posture group, the odds ratios (ORs) of LBP for workers who pushed and pulled were not significantly different compared with those of no-handling workers. However, in the improper working posture group, the ORs of LBP were significantly greater among workers who pushed and pulled compared with those of no-handling workers, and this association became stronger with increasing weights. Therefore, improper working posture combined with pushing and pulling were strongly associated with LBP among workers, particularly with heavier weights.

Research on the Effect of Intelligent Push on Consumers’ Purchasing Intention

Research on the Effect of Intelligent Push on Consumers’ Purchasing Intention

Fluorinated Metal–Organic Framework–Polymer Mixed Matrix Membrane with Tunable Hydrophobic Channel for Efficient Pervaporation of Butanol/Water

The permeability–selectivity trade‐off of membrane is a major challenge limiting the development of pervaporation (PV) technology. Rational design of high‐performance mixed matrix membranes (MMMs) has the potential to break off the trade‐off. Herein, a solvent‐assisted linker exchange‐based strategy is reported to introduce fluoroalkyl into metal–organic framework‐808 (MOF‐808). The pore size of fluorinated MOF‐808 can be adjusted with fluoroalkyl of different chain length (like trifluoromethyl and pentafluoropropyl). Then, the fluorinated MOF‐808/polyether block amide (PEBA) MMMs are prepared for the PV of n‐butanol/water. Compared with pristine PEBA membrane, 20 wt% 3F‐MOF‐808(P)/PEBA MMMs (3F = ‐CF3 group; P = postmodification method) exhibit 69% increase in permeation flux and 33% increase in separation factor in the PV of 2.5 wt% n‐butanol aqueous solutions at 70 °C. Based on Grand Canonical Monte Carlo and molecular dynamics simulations, fluorinated MOF‐808 shows better butanol affinity (pull effect) and stronger water repulsion ability (push effect). And the “push–pull effect” between fluorinated MOF‐808 with butanol/water is helpful to enhance the PV performance of MMMs. The application of “push–pull effect” provides a new strategy for the rational design of high‐performance MMMs, which is of great significance for the in‐depth research and application of PV technology.

Effect of Intravenous Push and Piggyback Administration of Ceftriaxone on Mortality in Sepsis

BackgroundThere is a lack of evidence-based guidelines for the administration methods of ceftriaxone in emergency departments (EDs), resulting in the reliance on individual institutional protocols for decision-making. ObjectiveThis study was performed to compare the effects of administering ceftriaxone via intravenous push (IVP) and intravenous piggyback (IVPB) on 28-day mortality in patients with sepsis. MethodsThis was a retrospective study of patients aged 18 years or older with sepsis or septic shock who visited an ED and were treated with ceftriaxone as an initial antibiotic between March 2010 and February 2019. Patients were divided into the IVP group and the IVPB group based on the administration method. The primary outcome was 28-day mortality, and multivariable Cox proportional hazards regression analysis was performed to evaluate the relationship between antibiotic administration methods and 28-day mortality. ResultsDuring the study period, a total of 939 patients were included in the final analysis, and the overall mortality rate was 12.2%. The antibiotic administration time was significantly lower in the IVP group than in the IVPB group, and the rates of antibiotic administration within 1 h and within 3 h were higher in the IVP group than in the IVPB group (p < 0.05). However, there was no significant difference in 28-day mortality between the two groups (hazard ratio 1.07, 95% confidence interval 0.69–1.65). ConclusionsIVP administration of ceftriaxone reduced the time of antibiotic administration compared with IVPB, but there was no difference in 28-day mortality.

Simulation-based comparison of push- and pull-based planning in panelized construction

Offsite construction involves the prefabrication of construction components in a factory environment, followed by transportation to the construction site for assembly. In planning the sequences for construction tasks, a push approach can maximize the offsite manufacturing capacity, while a pull approach can achieve just-in-time delivery. Both approaches need to consider the logical constraints and resources of offsite construction processes. This complexity fuels a debate of the effectiveness of push- and pull-based planning, highlighting the necessity to study the impacts of these approaches on planning. This study utilizes Discrete-Event Simulation (DES) and Agent-Based Modeling (ABM) approaches to compare planning outcomes for offsite construction. The results demonstrate that the pull-based planning approach resulted in an overall 12.6% reduction in project completion time and an 80.3% reduction in product waiting time, demonstrating pull-based planning as a more efficient solution for offsite construction planning.

The effect of local versus remote Beta‐Amyloid on functional connectivity mediated Tau‐Spread in Alzheimer’s Disease

AbstractBackgroundIn Alzheimer’s disease (AD), Amyloid‐beta deposition (Ab) is associated with tau spreading from epicenters to connected regions. Yet, Ab and tau accumulate in strikingly different patterns, and it is unclear how Abdrives tau spreading. We envision two mechanisms, i.e. i) that cortical Ab exerts remote effects and “pulls” tau out of connected epicenters or ii) that tau is pushed out of epicenters, once Ab has reached the tau epicenters (Fig.1A). We tested both mechanisms in AD spectrum patients and determined the predominant mechanism by which Ab drives tau spreading.MethodsWe included 313 ADNI participants (n = 110 CN Ab‐, n = 98 CN‐Ab+, n = 70 MCI Ab+, n = 35 Dementia Ab+), with baseline amyloid‐ and longitudinal tau‐PET, based on which we calculated tau‐PET rates of change (ROC) for 200 cortical ROIs (Schaefer‐atlas; Fig.2). Using the same atlas, a resting‐state fMRI‐connectivity template was obtained in 42 healthy controls. For each subject, we determined tau epicenters as 5% of ROIs with highest baseline tau‐PET and assessed epicenter connectivity. Using ROI‐wise regression, we tested whether faster tau‐PET increase was explained by the simultaneous occurrence of i) higher tau‐PET in the epicenter, ii) stronger connectivity to the tau epicenter and iii) higher Ab in the target region (i.e. pull‐effect) or the tau epicenter (i.e. push‐effect). Lastly, we assessed ROI‐wise main effects of local Ab vs. Ab in the tau epicenter on tau‐PET changes, to determine which mechanism predominates.ResultsHigher tau and Ab in the epicenter explained faster tau‐PET increase in connected temporo‐parietal and frontal regions (Ab‐push‐effect, Fig.1B). In contrast, Ab‐pull‐effects were found also for late‐Braak regions (Fig.1C). Congruently, we found that Ab push effects dominated over Ab‐pull effects in temporo‐parietal brain regions, whereas Ab‐pull effects dominated in late‐Braak regions (Fig.1D‐F). Lastly, patients in which Ab and tau converged locally showed fastest subsequent tau accumulation (Fig.3).ConclusionAb exerts local and remote effects on tau spreading, yet local convergence of Ab and tau in the epicenter may predominantly drive tau spreading. Thus, local convergence of Ab and tau is a key event in AD that gives rise to accelerated tau spreading, previously referred to as cataustrophy.

The effect of local versus remote Beta‐Amyloid on functional connectivity mediated Tau‐Spread in Alzheimer’s Disease

AbstractBackgroundIn Alzheimer’s disease (AD), Amyloid‐beta deposition (Ab) is associated with tau spreading from epicenters to connected regions. Yet, Ab and tau accumulate in strikingly different patterns, and it is unclear how Abdrives tau spreading. We envision two mechanisms, i.e. i) that cortical Ab exerts remote effects and “pulls” tau out of connected epicenters or ii) that tau is pushed out of epicenters, once Ab has reached the tau epicenters (Fig.1A). We tested both mechanisms in AD spectrum patients and determined the predominant mechanism by which Ab drives tau spreading.MethodWe included 313 ADNI participants (n = 110 CN Ab‐, n = 98 CN‐Ab+, n = 70 MCI Ab+, n = 35 Dementia Ab+), with baseline amyloid‐ and longitudinal tau‐PET, based on which we calculated tau‐PET rates of change (ROC) for 200 cortical ROIs (Schaefer‐atlas; Fig.2). Using the same atlas, a resting‐state fMRI‐connectivity template was obtained in 42 healthy controls. For each subject, we determined tau epicenters as 5% of ROIs with highest baseline tau‐PET and assessed epicenter connectivity. Using ROI‐wise regression, we tested whether faster tau‐PET increase was explained by the simultaneous occurrence of i) higher tau‐PET in the epicenter, ii) stronger connectivity to the tau epicenter and iii) higher Ab in the target region (i.e. pull‐effect) or the tau epicenter (i.e. push‐effect). Lastly, we assessed ROI‐wise main effects of local Ab vs. Ab in the tau epicenter on tau‐PET changes, to determine which mechanism predominates.ResultHigher tau and Ab in the epicenter explained faster tau‐PET increase in connected temporo‐parietal and frontal regions (Ab‐push‐effect, Fig.1B). In contrast, Ab‐pull‐effects were found also for late‐Braak regions (Fig.1C). Congruently, we found that Ab push effects dominated over Ab‐pull effects in temporo‐parietal brain regions, whereas Ab‐pull effects dominated in late‐Braak regions (Fig.1D‐F). Lastly, patients in which Ab and tau converged locally showed fastest subsequent tau accumulation (Fig.3).ConclusionAb exerts local and remote effects on tau spreading, yet local convergence of Ab and tau in the epicenter may predominantly drive tau spreading. Thus, local convergence of Ab and tau is a key event in AD that gives rise to accelerated tau spreading, previously referred to as cataustrophy.

Understanding the key risks in circular construction projects: from systematic review to conceptual framework

Purpose Circular construction offers sustainable solutions and opportunities to disentangle a project’s life cycle, including demolition, deconstruction and repurposing of architectural, civil engineering and infrastructure projects from the extraction of natural resources and their wasteful usage. However, it introduces additional layers of novel risks and uncertainties in the delivery of projects. The purpose of this study is to review the relevant literature to discover, classify and theorize the critical risk factors for circular construction projects. Design/methodology/approach The paper conducted a systematic literature review to investigate the risks of circular construction projects. It deployed a multistage approach, including literature search and assessment, metadata extraction, citation frequency analysis, Pareto analysis and total interpretive structural modeling. Findings Sixty-eight critical risk factors were identified and categorized into nine broad taxonomies: material risks, organizational risks, supply chain risks, technological risks, financial risks, design risks, health and safety risks, regulatory risks and stakeholder risks. Using the Pareto analysis, a conceptual map of 47 key critical risk factors was generated for circular construction projects. A hierarchical model was further developed to hypothesize the multiple possible connections and interdependencies of the taxonomies, leading to chain reactions and push effects of the key risks impacting circular construction projects. Originality/value This study constitutes the first systematic review of the literature, consolidating and theorizing the chain reactions of the critical risk factors for circular construction projects. Thus, it provides a better understanding of risks in circular construction projects.

Factors Influencing Switching Intention and Customer Retention of Over-the-Top (OTT) Viewing Behavior in Taiwan: The Push–Pull– Mooring Model

The proliferation of over-the-top (OTT) platforms, offering a wide array of on-demand content accessible through the Internet, has reshaped the media landscape and transformed viewing habits. This has led to a decline in traditional cable TV subscriptions and reduced revenue for telecom operators who often bundle TV services with their broadband offerings. The acquisition of customers and retention of existing ones are critical objectives of OTT service providers in Taiwan, and understanding consumer switching behavior can assist them in maintaining their competitiveness. Therefore, the current study applied the push–pull–mooring model to delineate the determinants of users’ switching and retention intention on OTT services. An online survey of 500 individuals was conducted to collect data for this research. This study investigates the factors that affect users who switch or stay in OTT services to gain a specific understanding of how push (service value and customer satisfaction), pull (attractiveness of alternatives and social influence), and mooring (switching costs and habit) effects shape their behavior. Our empirical model provides compelling rationales for understanding the principal antecedents of switching and retention intentions. In addition to push and pull effects, this study also highlights the importance of examining the moderating effects of OTT switching behaviors, such as switching costs and habit experience. Moreover, this study empirically and theoretically extends the understanding of push, pull, and mooring effects on OTT service-switching decisions.

Effect of push–Pull functional group on the ESIPT behaviour and photophysical property of thiolflavone-based compound: a TD-DFT investigation

ABSTRACT The excited-state intramolecular proton transfer (ESIPT) mechanism and photophysical properties of three –CN-substituted (2-(4-(diethylamino)phenyl)- 3-mercapto-4H-chromen-4-one (3-NTF) compounds (3NTF-1, 3NTF-2, 3NTF-3) have been studied systematically based on density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. We analysed the structural parameters, infrared frequencies and electron densities of the studied compounds, and found that the intramolecular hydrogen bonds (IHBs) at tautomer form are weakened in the excited (S1) state. The weaker IHB at tautomer form is beneficial to ESIPT process. The potential energy curves (PECs) were established and showed that the ESIPT processes of 3NTF-1 and 3NTF-2 are barrierless. The ESIPT process of 3NTF-3 needs to overcome a very low energy barrier. The electron-withdrawing group (–CN) increases the energy barrier of ground state intramolecular proton transfer (GSIPT) process in 3NTF. The order of GSIPT barrier is consistent with the order of their IHB strengths of normal forms. When the electron-withdrawing group (–CN) was introduced, the absorption and fluorescence peaks red-shifted. Two –CN groups resulted in the fluorescence peak of 3NTF red-shift more than one –CN group did.

Time-variation in the effects of push and pull factors on portfolio flows: Evidence from a Bayesian dynamic factor model

The extent to which push and pull factors affect international capital flows is widely debated. We contribute to this strand of literature by estimating the relative importance of push and pull factors for portfolio flows over a time span, encompassing the global financial crisis, the European sovereign debt crisis as well as the beginning of the Covid-19 pandemic. To do so, we extract common and country-specific components from fund flow data using Bayesian dynamic factor models with time-varying coefficients and stochastic volatility. Assuming that the common component represents push factors and the country-specific component pull factors, we show that (i) time-variation matters and (ii) there is a substantial amount of heterogeneity in the importance of factors across regions (advanced versus emerging market economies) and asset classes (equity versus bonds). We find that the relative importance of push factors for flows into advanced economies has on average increased over time, particularly for EU countries. With respect to flows into emerging market economies, we find very heterogeneous results between individual countries. Moreover, we identify risk measures, US stock market returns, US real interest rates, the US real effective exchange rate and the oil price as important push factors. Pull factors seem to covary with domestic stock market returns, in particular.

Food Insecurity Resilience Capacity of Rural Households in the Face of Induced-Weather Extremities in Bauchi State of Nigeria

It is no longer a chasm that human existence is being threatened by induced-weather vagaries. Given the dynamic nature of the weather vagaries, if tacit actions are not taken on continuum basis, soonest, human race will go into extinction because of the steep devastating push effect of climate change. It is in lieu of the foregoing, that the researchers conceptualized a study that assessed rural households’ food insecurity resilience capacity in Nigeria’s Bauchi state using a resilience index measurement analysis (RIMA II), a novel methodological approach developed by FAO for studying such scenario, as literature review showed no evidence of its application in the study area. Adopting a multi-stage random sampling technique, a total of 322 households were randomly sampled from a sampling frame obtained by a reconnaissance survey. Using a well-structured questionnaire complemented with interview schedule, rural households’ survey data were collected in the year 2022. Besides, the collected data were analyzed using both descriptive and inferential statistics. Empirically, it was established that the study area is challenged with food insecurity that owes majorly to poor food utilization and stability. Besides, poor food insecurity resilience capacity majorly due to vulnerable adaptive capacity was unmasked as the push effect behind food insecurity bane in the study area. However, evidence showed that food insecurity resilience capacity has a lasting effect on general well-being of rural households while households’ hunger resilience capacity has a transitory effect as it can only contain food crises on the short-term basis. Nevertheless, income and consumption smoothening were the commonest short-term food coping strategies adopted in the study area. To achieve the sustainable development goals of zero hunger by 2030, it becomes imperative on policymakers to sensitize rural households on the need to adopt safe and eco-friendly improved indigenous food technologies so as to address the poor states of food utilization and stability affecting food security of the study area.

378 Effect of Intravenous Push and Piggyback Administration of Ceftriaxone on the Mortality in Sepsis

378 Effect of Intravenous Push and Piggyback Administration of Ceftriaxone on the Mortality in Sepsis

Switching channels: investigating the push, pull, and mooring effects of moving from cable TV to OTT services

ABSTRACT In recent years, Over-the-Top (OTT) streaming services have become increasingly popular as a form of digital leisure, triggering a significant shift of users from traditional television. This research article uses the Push Pull Mooring Framework to explore the factors that influence the switching intention from traditional cable TV to OTT. The results showed that frustration with TV, convenience, trialability, and trendiness positively impact switching intention. In contrast, cognitive lock-in has a negative impact. The study contributes to the literature by being the first to use the Push Pull Mooring Framework to explain the switching intention from traditional TV to OTT. These insights could be instrumental in formulating impactful strategies to maintain or attract viewers, thereby shaping the future dynamics of leisure activities.